INT157927

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Context Info
Confidence 0.64
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 6.55
Pain Relevance 2.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Scn1a) plasma membrane (Scn1a)
Anatomy Link Frequency
pore 1
brain 1
Scn1a (Mus musculus)
Pain Link Frequency Relevance Heat
sodium channel 14 98.92 Very High Very High Very High
Calcium channel 1 96.76 Very High Very High Very High
Nav1.7 30 95.32 Very High Very High Very High
Nav1.1 5 94.24 High High
Migraine 47 91.32 High High
anticonvulsant 9 89.60 High High
headache 9 85.12 High High
Action potential 1 84.96 Quite High
Pyramidal cell 1 75.68 Quite High
Pain 34 52.88 Quite High
Disease Link Frequency Relevance Heat
Syndrome 139 99.80 Very High Very High Very High
Myoclonic Epilepsies 12 99.80 Very High Very High Very High
Disease 51 99.60 Very High Very High Very High
Convulsion 216 97.04 Very High Very High Very High
Targeted Disruption 10 96.00 Very High Very High Very High
Epilepsy 74 93.08 High High
Febrile Convulsions 180 92.80 High High
Migraine With Aura 17 91.32 High High
Migraine Without Aura 3 90.32 High High
Paresis 1 86.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The SCN1A-KI mice well reproduced the SMEI disease phenotypes.
Gene_expression (reproduced) of SCN1A associated with myoclonic epilepsies and disease
1) Confidence 0.64 Published 2009 Journal Brain Dev. Section Abstract Doc Link 19203854 Disease Relevance 1.01 Pain Relevance 0.25
The multifactorial etiology of Dravet syndrome proposed by many investigators suggests that it is very likely that genes responsible for Dravet syndrome will far outnumber SCN1A and SCN9A.
Gene_expression (outnumber) of SCN1A associated with syndrome
2) Confidence 0.63 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730533 Disease Relevance 1.36 Pain Relevance 0.04
In an analysis of a cohort of 109 Dravet syndrome patients, 50% of whom had SCN1A mutations, we found 8 additional SCN9A variants within the transmembrane domains and intracellular and extracellular loops of Nav1.7 in 9 patients (Table 1).
Gene_expression (mutations) of SCN1A associated with syndrome and nav1.7
3) Confidence 0.63 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730533 Disease Relevance 0.80 Pain Relevance 0.10
subunit genes including SCN1A, SCN2A and SCN3A that share over 85% identity and are highly expressed in brain [15].
Gene_expression (ly expres) of SCN1A in brain
4) Confidence 0.56 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730533 Disease Relevance 1.64 Pain Relevance 0.05
2-subunit of glial cell sodium-potassium (Na+-K+) pumps, and SCN1A (FHM3), encoding the pore-forming ?
Gene_expression (pumps) of SCN1A in pore
5) Confidence 0.31 Published 2010 Journal Mol Pain Section Body Doc Link PMC2974658 Disease Relevance 1.73 Pain Relevance 1.58

General Comments

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