INT157929

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.52
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
macrophages 1
poly 1
inflammatory monocytes 1
adult mouse 1
Ifnar1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 13 99.84 Very High Very High Very High
Cannabinoid 2 99.28 Very High Very High Very High
cytokine 69 99.16 Very High Very High Very High
Dorsal horn 1 96.80 Very High Very High Very High
Spinal cord 2 96.04 Very High Very High Very High
Central nervous system 52 94.28 High High
Lasting pain 1 94.00 High High
cannabis 1 86.24 High High
Dismenorea 2 56.16 Quite High
agonist 10 50.40 Quite High
Disease Link Frequency Relevance Heat
Infection 352 99.92 Very High Very High Very High
INFLAMMATION 15 99.84 Very High Very High Very High
Disease 70 98.68 Very High Very High Very High
Togavirus Infection 18 96.64 Very High Very High Very High
Pain 3 94.00 High High
Nervous System Injury 1 92.44 High High
Immunization 29 87.84 High High
Influenza Virus Infection 5 78.16 Quite High
Viral Infection 25 73.04 Quite High
Apoptosis 43 57.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whereas it is clear that an increased neonatal susceptibility is also observed in humans, the relevance of type-I IFN defect as a basis for severe infection in humans remains to be demonstrated.
Positive_regulation (relevance) of type-I associated with infection
1) Confidence 0.41 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2242832 Disease Relevance 0.73 Pain Relevance 0.06
In the neonatal host as well as in the adult mouse with a totally abrogated type-I IFN signaling, CHIKV-associated disease is particularly severe, and this severity correlates with higher viral loads and dissemination to the CNS.
Positive_regulation (abrogated) of type-I in adult mouse associated with central nervous system and disease
2) Confidence 0.41 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2242832 Disease Relevance 0.80 Pain Relevance 0.05
To address whether expression of the type I IFN receptor was required by B cells for the poly(I:C)-induced IgG2c TI-2 response antibody response, Ifnar1?
Positive_regulation (induced) of Ifnar1 in poly
3) Confidence 0.38 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2901065 Disease Relevance 0.37 Pain Relevance 0.03
The nonpsychotropic cannabinoid cannabidiol modulates and directly activates alpha-1 and alpha-1-Beta glycine receptor function.
Positive_regulation (activates) of alpha-1-Beta associated with cannabinoid
4) Confidence 0.09 Published 2009 Journal Pharmacology Section Title Doc Link 19204413 Disease Relevance 0.36 Pain Relevance 0.49
Notably, induction of type 1 interferon in inflammatory monocytes required internalization of TLR2.
Positive_regulation (induction) of type 1 interferon in inflammatory monocytes associated with inflammation
5) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816997 Disease Relevance 0.47 Pain Relevance 0.16
Increased type I IFN and innate immune proinflammatory cytokines might be expected to contribute to efficient control of WNV infection after IL-10 signaling blockade.
Positive_regulation (Increased) of I IFN associated with infection and cytokine
6) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2749443 Disease Relevance 0.40 Pain Relevance 0.13
Collectively, these data suggest that genetic blockade of IL-10 signaling results in a significant elevation of type I IFN and proinflammatory cytokines in macrophages, splenic cells and peripheral blood during WNV infection.
Positive_regulation (elevation) of I IFN in macrophages associated with infection and cytokine
7) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2749443 Disease Relevance 0.39 Pain Relevance 0.16

General Comments

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