INT157932

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Context Info
Confidence 0.48
First Reported 2005
Last Reported 2010
Negated 4
Speculated 3
Reported most in Body
Documents 46
Total Number 51
Disease Relevance 52.18
Pain Relevance 6.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
impression 2
blood 2
brain 1
neural 1
nucleus accumbens 1
ADHD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 1529 100.00 Very High Very High Very High
complementary and alternative medicine 22 99.90 Very High Very High Very High
Neurobehavioral 33 99.76 Very High Very High Very High
depression 203 98.68 Very High Very High Very High
alcohol 182 97.86 Very High Very High Very High
Nucleus accumbens 136 97.74 Very High Very High Very High
Glutamate 94 97.72 Very High Very High Very High
Somatosensory cortex 55 95.28 Very High Very High Very High
Locus ceruleus 92 95.00 High High
primary somatosensory cortex 34 94.08 High High
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 8305 100.00 Very High Very High Very High
Anxiety Disorder 322 99.80 Very High Very High Very High
Autism 93 99.80 Very High Very High Very High
Psychosis 188 99.52 Very High Very High Very High
Depression 241 99.48 Very High Very High Very High
Epilepsy 95 99.44 Very High Very High Very High
Coronary Heart Disease 23 99.34 Very High Very High Very High
Disease 161 99.12 Very High Very High Very High
Urological Neuroanatomy 31 98.52 Very High Very High Very High
Fatigue 14 98.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fast increase in number of children with headaches, scholar difficulties and suspect of ADHD has been observed.


Positive_regulation (increase) of ADHD
1) Confidence 0.48 Published 2008 Journal Prz. Lek. Section Body Doc Link 19205358 Disease Relevance 0 Pain Relevance 0
It is noteworthy that despite the observation that 62% of subjects showed a 30% reduction in ADHD symptoms, the scores on the ADHD rating scales at endpoint continued to be moderately elevated (21.2 ± 10.6) indicative of residual ADHD symptomatology.
Positive_regulation (elevated) of ADHD associated with attention deficit hyperactivity disorder
2) Confidence 0.44 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2515893 Disease Relevance 1.74 Pain Relevance 0
Medications used to treat ADHD including methylphenidate compounds are associated with small increases on heart rate and blood pressure, but the changes are usually modest with no clinically significant changes.13,14 As discussed in guidelines for the use of these medications for the treatment of ADHD in children and adults, the potential cardiovascular effects are generally considered acceptable and manageable and can be monitored as the physician feels necessary.9,31 As well, all drug products for the treatment of ADHD provide patient medication guides to inform about possible cardiovascular effects associated with of the medication.15
Positive_regulation (treat) of ADHD in blood associated with attention deficit hyperactivity disorder
3) Confidence 0.44 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2747385 Disease Relevance 0.75 Pain Relevance 0.05
Medications used to treat ADHD including methylphenidate compounds are associated with small increases on heart rate and blood pressure, but the changes are usually modest with no clinically significant changes.13,14 As discussed in guidelines for the use of these medications for the treatment of ADHD in children and adults, the potential cardiovascular effects are generally considered acceptable and manageable and can be monitored as the physician feels necessary.9,31 As well, all drug products for the treatment of ADHD provide patient medication guides to inform about possible cardiovascular effects associated with of the medication.15
Positive_regulation (treatment) of ADHD in blood associated with attention deficit hyperactivity disorder
4) Confidence 0.44 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2747385 Disease Relevance 0.67 Pain Relevance 0
The current diagnostic criteria for ADHD in adults have been previously criticized for its lacking of both clinical specificity and developmental sensitivity, since the diagnostic criteria were developed to be primarily applied in children and young adolescents.6 It is also imperative to acknowledge that many of the individuals who continue to experience symptoms of ADHD during adulthood commonly no longer have the same subsets of symptoms that were present during childhood and adolescence.
Positive_regulation (experience) of ADHD associated with attention deficit hyperactivity disorder
5) Confidence 0.42 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697545 Disease Relevance 1.57 Pain Relevance 0
Therefore, it has been difficult to estimate the rate of persistence of ADHD from childhood into adulthood, as prospective studies have produced mixed results.7,8
Positive_regulation (persistence) of ADHD associated with attention deficit hyperactivity disorder
6) Confidence 0.42 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697545 Disease Relevance 1.64 Pain Relevance 0.03
Although the signs described by Still are consistent with some symptoms of ADHD, they are not sufficient for a clinical diagnosis of ADHD.
Neg (not) Positive_regulation (sufficient) of ADHD associated with attention deficit hyperactivity disorder
7) Confidence 0.42 Published 2010 Journal Atten Defic Hyperact Disord Section Body Doc Link PMC3000907 Disease Relevance 1.21 Pain Relevance 0
The lack of evidence of a unique genetic, biological, or neurological pathology hinders the general acceptance of ADHD as a neurobehavioral disease entity.
Positive_regulation (acceptance) of ADHD associated with disease, attention deficit hyperactivity disorder and neurobehavioral
8) Confidence 0.42 Published 2010 Journal Atten Defic Hyperact Disord Section Body Doc Link PMC3000907 Disease Relevance 1.30 Pain Relevance 0.05
Many descriptions of children with this disorder include some characteristic symptoms of ADHD, and some behaviors of postencephalitic cases might also be attributed to ADHD.
Positive_regulation (attributed) of ADHD associated with attention deficit hyperactivity disorder
9) Confidence 0.42 Published 2010 Journal Atten Defic Hyperact Disord Section Body Doc Link PMC3000907 Disease Relevance 0.85 Pain Relevance 0.03
This can be interpreted as an early case of ADHD.
Positive_regulation (case) of ADHD associated with attention deficit hyperactivity disorder
10) Confidence 0.42 Published 2010 Journal Atten Defic Hyperact Disord Section Body Doc Link PMC3000907 Disease Relevance 0.16 Pain Relevance 0
Congenital heart disease patients have a slightly higher incidence of ADHD [127], and those affected might well benefit from ADHD therapies; including appropriately prescribed medication.
Positive_regulation (incidence) of ADHD in heart associated with attention deficit hyperactivity disorder and coronary heart disease
11) Confidence 0.41 Published 2010 Journal Eur Child Adolesc Psychiatry Section Body Doc Link PMC3012210 Disease Relevance 1.46 Pain Relevance 0
If psychotic symptoms do occur with ADHD drugs, then they could in very rare circumstances represent an adverse drug reaction or symptom of a psychotic disorder, but consideration should be given to the more likely possibility that psychotic symptoms are common phenomena in children and in most circumstances will be unrelated to either ADHD drugs or a psychotic disorder.
Positive_regulation (unrelated) of ADHD associated with adverse drug reaction, psychosis and attention deficit hyperactivity disorder
12) Confidence 0.41 Published 2010 Journal Eur Child Adolesc Psychiatry Section Body Doc Link PMC3012210 Disease Relevance 2.16 Pain Relevance 0.03
Children with epilepsies show a 3- to 5-fold higher prevalence of ADHD than controls [33].
Positive_regulation (prevalence) of ADHD associated with epilepsy and attention deficit hyperactivity disorder
13) Confidence 0.41 Published 2010 Journal Eur Child Adolesc Psychiatry Section Body Doc Link PMC3012210 Disease Relevance 1.49 Pain Relevance 0.16
Treatment of ADHD: Why use stimulants?
Positive_regulation (Treatment) of ADHD associated with attention deficit hyperactivity disorder
14) Confidence 0.40 Published 2005 Journal Theor Biol Med Model Section Body Doc Link PMC1352384 Disease Relevance 0.92 Pain Relevance 0
Whether this would be sufficient to account for an increase in frequency of ADHD and autism must await studies of the frequency of a range of genes by birth cohort.


Positive_regulation (increase) of ADHD associated with autism and attention deficit hyperactivity disorder
15) Confidence 0.40 Published 2005 Journal Theor Biol Med Model Section Body Doc Link PMC1352384 Disease Relevance 0.87 Pain Relevance 0
The difference is that since the levels of hyperactivity and inattention are much higher in ADHD subjects, the improvement is relatively much greater, giving the impression that they respond while non-ADHD subjects do not.
Positive_regulation (higher) of ADHD in impression associated with attention deficit hyperactivity disorder
16) Confidence 0.40 Published 2005 Journal Theor Biol Med Model Section Body Doc Link PMC1352384 Disease Relevance 1.20 Pain Relevance 0.21
A recent 4-year open label study of 384 adult patients demonstrated statistically significant improvement in ADHD symptom scores with minimal side effects, demonstrating the long-term efficacy and safety of atomoxetine.43 Despite being recommended as a first-line treatment for pediatric patients with ADHD because of its comparable efficacy with stimulant medications and low abuse potential, among adult patients its use has primarily been limited to patients with comorbid substance use, psychiatric and tic disorders.32,44
Positive_regulation (improvement) of ADHD associated with tourette's syndrome and attention deficit hyperactivity disorder
17) Confidence 0.40 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732009 Disease Relevance 1.22 Pain Relevance 0.03
BACKGROUND/AIM: Given the increasing prevalence of attention-deficit and attention-deficit hyperactivity disorders (ADHD), anesthesiologists are now presented with a greater number of children who are diagnosed with these conditions.
Positive_regulation (increasing) of ADHD associated with attention deficit hyperactivity disorder
18) Confidence 0.38 Published 2010 Journal Paediatr Anaesth Section Abstract Doc Link 20470335 Disease Relevance 0.28 Pain Relevance 0.16
First there may be a variable level of awareness among individuals when self-rating their own ADHD symptoms, leading to inaccurate ADHD symptom scores; and secondly self-ratings of ADHD symptoms may be confounded by adult onset conditions that generate ADHD-like symptoms, such as anxiety, depression, fatigue and drug and alcohol use.
Positive_regulation (generate) of ADHD associated with depression, anxiety disorder, fatigue, attention deficit hyperactivity disorder and alcohol
19) Confidence 0.37 Published 2010 Journal BMC Psychiatry Section Body Doc Link PMC2942810 Disease Relevance 1.32 Pain Relevance 0.10
Another limitation of these previous studies is that they did not report on whether or not the improvement of physical complaints coincided with improvements in ADHD symptoms.
Spec (whether) Positive_regulation (improvements) of ADHD associated with attention deficit hyperactivity disorder
20) Confidence 0.36 Published 2010 Journal Eur J Pediatr Section Body Doc Link PMC2908441 Disease Relevance 1.38 Pain Relevance 0

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