INT157941

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Context Info
Confidence 0.65
First Reported 2008
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 65
Total Number 67
Disease Relevance 20.39
Pain Relevance 9.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 17
lymph node 2
fibroblast 2
lymphocytes 2
spinal cord 1
IL-17 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 1378 100.00 Very High Very High Very High
Inflammation 889 100.00 Very High Very High Very High
Multiple sclerosis 600 99.82 Very High Very High Very High
Arthritis 615 99.72 Very High Very High Very High
rheumatoid arthritis 373 99.48 Very High Very High Very High
spastic colon 93 99.08 Very High Very High Very High
Spinal cord 710 98.00 Very High Very High Very High
psoriasis 54 93.92 High High
Potency 110 93.88 High High
chemokine 22 89.20 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 888 100.00 Very High Very High Very High
Osteoporosis 76 100.00 Very High Very High Very High
Autoimmune Disease 743 99.90 Very High Very High Very High
Multiple Sclerosis 998 99.82 Very High Very High Very High
Arthritis 419 99.72 Very High Very High Very High
Immunization 39 99.54 Very High Very High Very High
Rheumatoid Arthritis 373 99.48 Very High Very High Very High
Inflammatory Bowel Disease 387 99.30 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

92 99.08 Very High Very High Very High
Asthma 108 99.02 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, MP also inhibited gene expression of the essential IL-17-promoting transcription factor Ror?
Gene_expression (expression) of IL-17-promoting
1) Confidence 0.65 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0.24 Pain Relevance 0.14
remained after MP action is still adequate to inhibit IL-17 production since the addition of anti-IFN-?
Gene_expression (production) of IL-17
2) Confidence 0.65 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0.05 Pain Relevance 0.04
As the result, MP inhibited IL-17 generation in purified T lymphocytes, but less efficiently than in LNC (Fig 3A, B), thus suggesting that MP affected IL-17 production in LNC through direct influence on T cells and indirect influence on accessory cells.
Gene_expression (production) of IL-17 in T cells
3) Confidence 0.65 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0 Pain Relevance 0.06
As glucocorticoids are widely used in the treatment of CNS autoimmunity, we investigated the influence of MP on myelin basic protein (MBP)-induced IL-17 production.
Gene_expression (production) of IL-17 associated with autoimmune disease
4) Confidence 0.65 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0.28 Pain Relevance 0.19
for autoimmunity, one could speculate that the refractoriness to the therapy with GCs could be, at least partly, explained by the insufficient reduction of IL-17 production and possibly number and/or frequency of IL-17-producing cells.
Gene_expression (production) of IL-17 associated with autoimmune disease
5) Confidence 0.65 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0.94 Pain Relevance 0.24
production more potently than IL-17 production, irrespectively of experimental setting used.
Gene_expression (production) of IL-17
6) Confidence 0.65 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0 Pain Relevance 0.04
is inhibitory factor for IL-17 production (3, 4), and that we observed almost complete reduction of IFN-?
Gene_expression (production) of IL-17
7) Confidence 0.65 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0 Pain Relevance 0.04
Together, these results clearly showed that MP inhibits antigen-induced production of IL-17, but once again, its effect on IFN-?
Gene_expression (production) of IL-17
8) Confidence 0.65 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0.21 Pain Relevance 0.16
Similarly to results obtained in LNC the effect of MP on IL-17 production by purified T lymphocytes was weaker than its influence on IFN-?
Gene_expression (production) of IL-17 in T lymphocytes
9) Confidence 0.65 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0 Pain Relevance 0.06
inhibition was similar in LNC and purified T cells, contrary to the difference observed in the effect of MP on IL-17 production by LNC and purified T cells (Fig 3A–D).
Gene_expression (production) of IL-17 in T cells
10) Confidence 0.65 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0 Pain Relevance 0.04
In order to investigate whether the observed inhibition of IL-17 production in LNC was a consequence of direct or indirect effect of MP on T cells, CD3+ cells separation from LNC was performed.
Gene_expression (production) of IL-17 in T cells
11) Confidence 0.65 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0.19 Pain Relevance 0.15
As a result it was shown that MP potently inhibited IL-6 production in LPS-stimulated CD3- cells, thus suggesting that indirect influence of MP on IL-17 production could be, at least partly, conducted through inhibition of IL-6 production by non-T cells.


Gene_expression (production) of IL-17 in T cells
12) Confidence 0.65 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0 Pain Relevance 0.05
As a result, such an antibody, but not the irrelevant isotype control antibody, up-regulated IL-17 production, both in the presence or absence of MP, thus suggesting that IFN-?
Gene_expression (production) of IL-17
13) Confidence 0.65 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0 Pain Relevance 0.03
Accordingly, inhibitors of all of the three MAPKs collaborated with MP in its action against IL-17 generation, thus suggesting that MP did not use any of the signaling routes for its effect on IL-17 production.
Gene_expression (production) of IL-17
14) Confidence 0.65 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0.05 Pain Relevance 0.03
in reduction of IL-17 generation in lymph node cells
Gene_expression (generation) of IL-17 in lymph node
15) Confidence 0.65 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0 Pain Relevance 0.04
As a result, clear dose-dependent inhibition of IL-17 production was observed (Fig 1A).
Gene_expression (production) of IL-17
16) Confidence 0.65 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0.17 Pain Relevance 0.04
In our experimental settings, IL-17 production is less sensitive than IFN-?
Gene_expression (production) of IL-17
17) Confidence 0.65 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 1.11 Pain Relevance 0.29
T (Fig 1G), thus suggesting that the observed inhibition of IL-17 production was, at least partly, mediated through down-regulation of Ror?
Gene_expression (production) of IL-17
18) Confidence 0.65 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0.21 Pain Relevance 0.17
In order to explore indirect influence of MP on IL-17 production, which could be important for the observed difference in efficiency of MP in inhibition of IL-17 in purified T cells and LNC, CD3- cells were stimulated with LPS in the presence or absence of MP and production of a major IL-17-promoting cytokine – IL-6 was determined.
Gene_expression (production) of IL-17 in T cells associated with cytokine
19) Confidence 0.65 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0 Pain Relevance 0.05
The present work accordingly proves that MP potently inhibits IL-17 expression and production in a strong, mitogen-stimulated T cell response, as well as in more subtle, antigen-specific response of T lymphocytes.
Gene_expression (expression) of IL-17 in T lymphocytes
20) Confidence 0.65 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0.09 Pain Relevance 0

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