INT157959

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.48
First Reported 2007
Last Reported 2010
Negated 0
Speculated 5
Reported most in Body
Documents 32
Total Number 36
Disease Relevance 43.44
Pain Relevance 7.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (AQP4) plasma membrane (AQP4) transmembrane transport (AQP4)
cytoplasm (AQP4)
Anatomy Link Frequency
M-1 4
plasma 2
brain 2
glial cells 1
central nervous system 1
AQP4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 302 99.60 Very High Very High Very High
Multiple sclerosis 448 99.56 Very High Very High Very High
Demyelination 110 99.46 Very High Very High Very High
Migraine 3 98.24 Very High Very High Very High
Glutamate 324 97.84 Very High Very High Very High
Neuritis 362 97.56 Very High Very High Very High
Spinal cord 208 96.48 Very High Very High Very High
cytokine 16 95.52 Very High Very High Very High
intrathecal 20 92.76 High High
Inflammation 166 91.44 High High
Disease Link Frequency Relevance Heat
Neuromyelitis Optica 2585 100.00 Very High Very High Very High
Necrosis 15 99.70 Very High Very High Very High
Demyelinating Disease 849 99.56 Very High Very High Very High
Recurrence 373 99.40 Very High Very High Very High
Disease 551 99.24 Very High Very High Very High
Targeted Disruption 70 99.04 Very High Very High Very High
Transverse Myelitis 305 98.84 Very High Very High Very High
Headache 25 98.24 Very High Very High Very High
Optic Neuritis 350 97.56 Very High Very High Very High
Systemic Lupus Erythematosus 188 97.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The purpose of our work was to evaluate the association of polymorphisms in the AQP4 gene with the risk and the clinical features of migraine.
AQP4 gene Binding (association) of associated with migraine
1) Confidence 0.48 Published 2009 Journal J Headache Pain Section Abstract Doc Link 19209385 Disease Relevance 0.24 Pain Relevance 0.17
These recognize aquaporin 4 (AQP4), a protein that allows water to move through cell membranes.
aquaporin 4 Binding (recognize) of
2) Confidence 0.48 Published 2007 Journal PLoS Medicine Section Abstract Doc Link PMC1852124 Disease Relevance 1.83 Pain Relevance 0.31
These recognize aquaporin 4 (AQP4), a protein that allows water to move through cell membranes.
AQP4 Binding (recognize) of
3) Confidence 0.48 Published 2007 Journal PLoS Medicine Section Abstract Doc Link PMC1852124 Disease Relevance 1.84 Pain Relevance 0.31
The negative results in the rheumatological disease group also argue against nonspecific binding of patients' sera to AQP4.
AQP4 Binding (binding) of associated with disease
4) Confidence 0.48 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1852124 Disease Relevance 1.09 Pain Relevance 0.07
Antibody binding to M-23 AQP4 showed a laminar staining pattern, which could resemble the formation of OAPs.
AQP4 Binding (binding) of
5) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864757 Disease Relevance 0.38 Pain Relevance 0
The IgG was then precipitated using Protein A sepharose beads, washed thoroughly, and the amount of EGFP–AQP4 bound by antibody detected by counting the green fluorescence [arbitrary fluorescence units (FU)] at 512?
AQP4 Binding (bound) of
6) Confidence 0.43 Published 2008 Journal Brain Section Body Doc Link PMC2577801 Disease Relevance 0.40 Pain Relevance 0.03
Recent papers suggest stronger NMO-IgG Ab binding directed to the shorter M-23 AQP4 isoform [22], which in contrast to M-1 AQP4 can form orthogonal arrays (OAPs) [20], [28].
AQP4 isoform Binding (binding) of in M-1 associated with neuromyelitis optica
7) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864757 Disease Relevance 1.95 Pain Relevance 0.12
Dead cells were visualized with DAPI staining (Sigma-Aldrich) and live cells were analyzed for AQP4-Ig binding.
AQP4 Spec (analyzed) Binding (binding) of
8) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864757 Disease Relevance 0.09 Pain Relevance 0
On the contrary, IgG binding to full length AQP4, resulted in a more point shaped staining pattern.
AQP4 Binding (binding) of
9) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864757 Disease Relevance 0.88 Pain Relevance 0
Our study confirms weaker binding of NMO-IgG to full length AQP4, resulting in a lower sensitivity for clinically definite NMO (70%) and high risk NMO (39%) patients, besides also the M-23 IgG seropositive patient with SLE associated myelitis was negative for full length AQP4-IgG.
AQP4 Binding (binding) of associated with neuromyelitis optica, demyelinating disease and systemic lupus erythematosus
10) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864757 Disease Relevance 1.84 Pain Relevance 0.11
NMO-IgG mainly targets M-23 AQP4
AQP4 Binding (targets) of associated with neuromyelitis optica
11) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864757 Disease Relevance 1.35 Pain Relevance 0.16
NMO-Ig Abs resulted in different staining patterns when binding to full length AQP4 in contrast to the M-23 AQP4 isoform.
AQP4 Binding (binding) of associated with neuromyelitis optica
12) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864757 Disease Relevance 1.14 Pain Relevance 0.06
To summarize, weaker binding was observed to full length AQP4, which is also evident from the lower titer values of M-1 AQP4-IgG (Table 1).


AQP4 Binding (binding) of in M-1
13) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864757 Disease Relevance 1.92 Pain Relevance 0.20
M-1 and M-23 AQP4-IgG binding results in different staining patterns
AQP4-IgG Binding (binding) of in M-1
14) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864757 Disease Relevance 0.25 Pain Relevance 0
Our results suggest M-23 AQP4 as initial and major target antigen for antibody binding in definite and high risk NMO patients, whereas Abs to M-1 AQP4 are predominantly developed with increasing disease duration and severity.
AQP4 Binding (binding) of in M-1 associated with neuromyelitis optica and disease
15) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864757 Disease Relevance 1.12 Pain Relevance 0.13
Transfected HEK 293 cells express human AQP4 homotetramers closely packed on cell membranes [37], and allow detection of AQP4 autoantibodies binding to extracellular epitopes of human AQP4.
AQP4 Binding (binding) of
16) Confidence 0.35 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2941752 Disease Relevance 1.51 Pain Relevance 0.20
Lennon and colleagues discovered a biomarker for NMO; NMO-IgG is an autoantibody initially detected in the serum of 73% of NMO but less than 5% of CMS patients [10], which binds to aquaporin-4 (AQP4) [11], the most abundant water channel in the CNS [12-14].
aquaporin-4 Binding (binds) of associated with neuromyelitis optica and multiple sclerosis
17) Confidence 0.35 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2941752 Disease Relevance 2.62 Pain Relevance 0.71
Lennon and colleagues discovered a biomarker for NMO; NMO-IgG is an autoantibody initially detected in the serum of 73% of NMO but less than 5% of CMS patients [10], which binds to aquaporin-4 (AQP4) [11], the most abundant water channel in the CNS [12-14].
AQP4 Binding (binds) of associated with neuromyelitis optica and multiple sclerosis
18) Confidence 0.35 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2941752 Disease Relevance 2.62 Pain Relevance 0.72
In the presence of active complement, binding of NMO-IgG to surface AQP4 initiated robust complement activation and rapid loss of the target cell membrane's integrity.
AQP4 Binding (binding) of associated with neuromyelitis optica
19) Confidence 0.34 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 1.56 Pain Relevance 0.35
The reduction in astrocytic glutamate transport accompanying AQP4 down-regulation after exposure to NMO-IgG further supports our suggestion that AQP4 and EAAT2 are associated functionally in the plasma membrane.


AQP4 Binding (associated) of in plasma associated with neuromyelitis optica and glutamate
20) Confidence 0.34 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.57 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox