INT15796

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Context Info
Confidence 0.61
First Reported 1987
Last Reported 2010
Negated 11
Speculated 4
Reported most in Abstract
Documents 66
Total Number 72
Disease Relevance 25.43
Pain Relevance 20.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL2) extracellular region (IL2) cell adhesion (IL2)
cell-cell signaling (IL2)
Anatomy Link Frequency
T-cell 11
lymphocytes 3
plasma 2
brain 2
macrophage 1
IL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 551 100.00 Very High Very High Very High
Morphine 55 100.00 Very High Very High Very High
Analgesic 16 100.00 Very High Very High Very High
tramadol 14 100.00 Very High Very High Very High
abatacept 9 100.00 Very High Very High Very High
intrathecal 8 100.00 Very High Very High Very High
palliative 7 100.00 Very High Very High Very High
Antinociceptive 24 99.98 Very High Very High Very High
narcan 8 99.98 Very High Very High Very High
opiate 4 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Infection 155 100.00 Very High Very High Very High
Cancer 119 100.00 Very High Very High Very High
Systemic Lupus Erythematosus 51 100.00 Very High Very High Very High
Necrosis 36 100.00 Very High Very High Very High
Immunization 40 99.74 Very High Very High Very High
Disease 297 99.36 Very High Very High Very High
Neuropathic Pain 10 99.36 Very High Very High Very High
Syndrome 27 99.20 Very High Very High Very High
Nociception 12 99.20 Very High Very High Very High
Eosinophilia 6 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We aimed to observe the effects of morphine, fentanyl and tramadol on NF-kappa B and IL-2 from both laboratory and clinical perspective.
Regulation (effects) of IL-2 associated with tramadol and morphine
1) Confidence 0.61 Published 2006 Journal J. Huazhong Univ. Sci. Technol. Med. Sci. Section Abstract Doc Link 17120754 Disease Relevance 0 Pain Relevance 0.94
The effect of adenovirus-mediated interleukin-2 (IL-2) gene on rat basal nociceptive response and chronic neuropathic pain was explored.
Regulation (effect) of IL-2 associated with nociception and neuropathic pain
2) Confidence 0.61 Published 2003 Journal Gene Ther. Section Abstract Doc Link 12883536 Disease Relevance 0.53 Pain Relevance 0.43
The volunteers were randomly assigned to the following groups: (1) control (no desflurane, no IL-2); (2) IL-2 alone; (3) desflurane alone; and (4) desflurane plus IL-2.
Regulation (control) of IL-2
3) Confidence 0.45 Published 1999 Journal Anesthesiology Section Body Doc Link 10360856 Disease Relevance 0.08 Pain Relevance 0
The volunteers were randomly assigned to the following groups: (1) control (no desflurane, no IL-2); (2) IL-2 alone; (3) desflurane alone; and (4) desflurane plus IL-2.
Regulation (control) of IL-2
4) Confidence 0.45 Published 1999 Journal Anesthesiology Section Body Doc Link 10360856 Disease Relevance 0.08 Pain Relevance 0
This study was performed to evaluate the effect of intrathecal delivery of human IL-2 gene on rat chronic neuropathic pain induced by chronic constriction injury of the sciatic nerve.
Regulation (effect) of IL-2 gene in sciatic nerve associated with eae, injury, neuropathic pain, sciatic nerve and intrathecal
5) Confidence 0.45 Published 2002 Journal Neuroscience Section Abstract Doc Link 12044458 Disease Relevance 0.44 Pain Relevance 0.75
This additive immunosuppression was not likely to have been related to these drugs' effects on interleukin-2 (IL-2) circuitry, since no additive inhibition of IL-2 production or IL-2 responsiveness was found.
Regulation (effects) of IL-2
6) Confidence 0.45 Published 1991 Journal Am. J. Med. Section Abstract Doc Link 2039018 Disease Relevance 0.48 Pain Relevance 0.14
This additive immunosuppression was not likely to have been related to these drugs' effects on interleukin-2 (IL-2) circuitry, since no additive inhibition of IL-2 production or IL-2 responsiveness was found.
Regulation (effects) of interleukin-2
7) Confidence 0.45 Published 1991 Journal Am. J. Med. Section Abstract Doc Link 2039018 Disease Relevance 0.48 Pain Relevance 0.14
At this point side effect of IL-2 therapy was suspected, then IL-2 was discontinued.
Regulation (effect) of IL-2
8) Confidence 0.45 Published 2009 Journal Nippon Hinyokika Gakkai Zasshi Section Abstract Doc Link 19663247 Disease Relevance 1.26 Pain Relevance 0.10
Effect of interleukin 2 on the production of progesterone and prostaglandin E2 in human fetal membranes and its consequences for preterm uterine contractions.
Regulation (Effect) of interleukin 2 in uterine associated with dismenorea
9) Confidence 0.45 Published 1994 Journal Eur. J. Endocrinol. Section Title Doc Link 8180676 Disease Relevance 0.34 Pain Relevance 0.10
Whereas in group T, IL-2 was unchanged 1 h after operation but was significantly elevated 3 and 24 h after operation.
Neg (unchanged) Regulation (unchanged) of IL-2
10) Confidence 0.45 Published 2006 Journal J. Huazhong Univ. Sci. Technol. Med. Sci. Section Abstract Doc Link 17120754 Disease Relevance 0 Pain Relevance 1.28
[A new domain of interleukin-2 and its analgesic effect in central nervous system].
Regulation (effect) of interleukin-2 in central nervous system associated with analgesic and central nervous system
11) Confidence 0.45 Published 1996 Journal Sheng Li Ke Xue Jin Zhan Section Title Doc Link 9592238 Disease Relevance 0 Pain Relevance 0.86
The effects of interleukin-2 (IL-2) on muscular Na+ currents were studied in human myoballs.
Regulation (effects) of interleukin-2
12) Confidence 0.45 Published 1994 Journal Pflugers Arch. Section Abstract Doc Link 8146027 Disease Relevance 0 Pain Relevance 0.08
The effects of interleukin-2 (IL-2) on muscular Na+ currents were studied in human myoballs.
Regulation (effects) of IL-2
13) Confidence 0.45 Published 1994 Journal Pflugers Arch. Section Abstract Doc Link 8146027 Disease Relevance 0 Pain Relevance 0.08
OBJECTIVE: Several cytokines, particularly IL-2 and interferons, are thought to be effective in the palliative therapy of neoplastic effusions.
Regulation (effective) of IL-2 associated with palliative and cytokine
14) Confidence 0.44 Published 2001 Journal Oncology Section Abstract Doc Link 11408797 Disease Relevance 0 Pain Relevance 0.22
The IL-2 levels of sera were 3.18 +/- 1.8 U/ml (mean +/- SD) in the healthy controls, 2.29 +/- 2.6 U/ml in the patients with migraine and 1.59 +/- 1.0 U/ml in the patients with TH.
Regulation (controls) of IL-2 associated with migraine and headache
15) Confidence 0.44 Published 1991 Journal Headache Section Abstract Doc Link 1860789 Disease Relevance 1.14 Pain Relevance 1.24
Investigations in some laboratories, including ours, have also demonstrated an analgesic effect of IL-2 in the CNS.
Regulation (effect) of IL-2 associated with analgesic
16) Confidence 0.44 Published 1998 Journal Biol Signals Recept Section Abstract Doc Link 9672758 Disease Relevance 0 Pain Relevance 0.35
Intrapleural administration of IL-2 is reported to be effective both in tumor-associated malignant pleurisy and on primary mesothelioma, whereas few data exist about IL-2 systemic administration.
Regulation (effective) of IL-2 associated with malignant neoplastic disease, lung cancer, cancer and pleurisy
17) Confidence 0.43 Published 2001 Journal Lung Cancer Section Abstract Doc Link 11165411 Disease Relevance 1.40 Pain Relevance 0.16
Clinical studies are needed on the effect of MLT in combination with IL-2 or other cytokines in cancer patients and viral diseases including HIV-infected patients.
Regulation (effect) of IL-2 associated with virus diseases, cancer, acquired immune deficiency syndrome or hiv infection and cytokine
18) Confidence 0.39 Published 1999 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 10721059 Disease Relevance 0.87 Pain Relevance 0.05
This study was to examine the effects of microinjection of human recombinant interleukin 2 (IL-2) into locus coeruleus (LC) on spinal nociception.
Spec (examine) Regulation (effects) of IL-2 in spinal associated with nociception and locus ceruleus
19) Confidence 0.39 Published 2000 Journal Neuropeptides Section Abstract Doc Link 11021983 Disease Relevance 0.26 Pain Relevance 0.31
Since some of the T cell defects could be explained by lack of IL-2, we have been investigating the effects of in vivo IL-2 treatment.
Spec (investigating) Regulation (effects) of IL-2 in T cell
20) Confidence 0.38 Published 2001 Journal Clin. Immunol. Section Abstract Doc Link 11465947 Disease Relevance 0.93 Pain Relevance 0

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