INT15797

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Context Info
Confidence 0.67
First Reported 1991
Last Reported 2011
Negated 2
Speculated 1
Reported most in Body
Documents 36
Total Number 38
Disease Relevance 15.17
Pain Relevance 5.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HLA-E)
Anatomy Link Frequency
muscle 3
macrophages 2
B cells 2
embryos 1
dendrites 1
HLA-E (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 54 99.80 Very High Very High Very High
cINOD 40 99.78 Very High Very High Very High
Inflammation 361 99.56 Very High Very High Very High
Substantia nigra 147 99.56 Very High Very High Very High
cytokine 299 99.00 Very High Very High Very High
Inflammatory response 39 95.16 Very High Very High Very High
Dopamine 3 94.92 High High
aspirin 84 93.56 High High
rheumatoid arthritis 293 92.32 High High
palliative 2 91.36 High High
Disease Link Frequency Relevance Heat
Apoptosis 81 99.60 Very High Very High Very High
INFLAMMATION 405 99.56 Very High Very High Very High
Cancer 248 99.52 Very High Very High Very High
Viral Infection 16 98.88 Very High Very High Very High
Disease 355 98.74 Very High Very High Very High
Death 243 98.44 Very High Very High Very High
Celiac Disease 58 98.40 Very High Very High Very High
Immunization 8 98.32 Very High Very High Very High
Targeted Disruption 37 96.86 Very High Very High Very High
Alzheimer's Dementia 4 94.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MHCI proteins are also necessary for immunological synapse formation [85].
Positive_regulation (necessary) of MHC in synapse
1) Confidence 0.67 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0.04
Moreover, the observed upregulation of MHCI levels in response to monocular enucleation points to a possible role in synaptogenesis.


Positive_regulation (upregulation) of MHC
2) Confidence 0.67 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0
BE did not increase the amount of class II MHC antigens on monocytes and did not preferentially stimulate CD69, CD25 and CD71 antigen expression on either CD4+ or CD8+ lymphocytes.
Neg (not) Positive_regulation (increase) of MHC in lymphocytes
3) Confidence 0.49 Published 1991 Journal J. Biol. Regul. Homeost. Agents Section Abstract Doc Link 1763657 Disease Relevance 0 Pain Relevance 0.08
NSAID treatment upregulated genes at the MHC locus on chromosome 6p21 in tumor tissue, but not in normal colon tissue, from the same patient. 23 of the 100 most upregulated genes belonged to MHC class II.
Neg (not) Positive_regulation (upregulated) of MHC in colon associated with cancer and cinod
4) Confidence 0.49 Published 2008 Journal Cancer Immun. Section Abstract Doc Link 18307280 Disease Relevance 0.68 Pain Relevance 0.51
RESULTS: A twofold increase of A3, B7, and DR2(15) MHC antigens was observed in the study population compared to control frequencies.
Positive_regulation (increase) of MHC
5) Confidence 0.49 Published 1994 Journal Clin J Pain Section Body Doc Link 7833579 Disease Relevance 0.14 Pain Relevance 0
Activated microglia express high levels of MHC glycoproteins and receptors for complement.
Positive_regulation (levels) of MHC in microglia
6) Confidence 0.49 Published 1996 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 8624086 Disease Relevance 0.60 Pain Relevance 0.13
This idea is supported by the increase in MHC heterozygosity of mouse embryos following viral infection of the parents [18].
Positive_regulation (increase) of MHC heterozygosity in embryos associated with viral infection
7) Confidence 0.46 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2861700 Disease Relevance 0.10 Pain Relevance 0
However, the specific fast MHC isoforms that are induced (usually the MHC-IIx isoform in slow muscle and the MHC-IIb isoform in fast muscle) and the degree and rate of adaptation are dependent upon the animal species and the specific model or condition that is being studied.
Positive_regulation (induced) of MHC in muscle
8) Confidence 0.36 Published 2000 Journal Muscle Nerve Section Abstract Doc Link 10797389 Disease Relevance 0.15 Pain Relevance 0.25
However, the specific fast MHC isoforms that are induced (usually the MHC-IIx isoform in slow muscle and the MHC-IIb isoform in fast muscle) and the degree and rate of adaptation are dependent upon the animal species and the specific model or condition that is being studied.
Positive_regulation (induced) of MHC in muscle
9) Confidence 0.36 Published 2000 Journal Muscle Nerve Section Abstract Doc Link 10797389 Disease Relevance 0.16 Pain Relevance 0.26
However, the specific fast MHC isoforms that are induced (usually the MHC-IIx isoform in slow muscle and the MHC-IIb isoform in fast muscle) and the degree and rate of adaptation are dependent upon the animal species and the specific model or condition that is being studied.
Positive_regulation (induced) of MHC-IIb isoform in muscle
10) Confidence 0.36 Published 2000 Journal Muscle Nerve Section Abstract Doc Link 10797389 Disease Relevance 0.15 Pain Relevance 0.25
This potential excess of high MHC similarity in European non-mate pairs is not seen in other populations (Figure S2) or in autosomal similarity (not shown).
Positive_regulation (excess) of MHC
11) Confidence 0.31 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2861700 Disease Relevance 0 Pain Relevance 0
3 sample (Text S3) and yielded similar results for MHC dissimilarity (Table 1, Table S2, and Text S5), despite the smaller and partially distinct set of SNPs genotyped in Hap3.
Positive_regulation (results) of MHC
12) Confidence 0.29 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2861700 Disease Relevance 0 Pain Relevance 0
There is also evidence reported for increased MHC divergence and positive selection among members of mammals [26].
Positive_regulation (increased) of MHC
13) Confidence 0.25 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1522023 Disease Relevance 0 Pain Relevance 0
RESULTS: Tumor cells up-regulated the surface molecules Fas (100% of cell lines up-regulated Fas), carcinoembryonic antigen (90%), mucin-1 (60%), MHC class I (50%), and intercellular adhesion molecule-1 (40%) in response to (153)Sm-EDTMP.
Positive_regulation (up-regulated) of MHC
14) Confidence 0.25 Published 2008 Journal Clin. Cancer Res. Section Body Doc Link 18594006 Disease Relevance 0.07 Pain Relevance 0
Based on these data, we hypothesized that advantageous genetic diversity might enhance not only antigen presentation and recognition (e.g., MHC and KIR), but also earlier steps of the MHC antigen presentation pathway.
Spec (might) Positive_regulation (enhance) of MHC
15) Confidence 0.24 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0.47 Pain Relevance 0.13
Haplotype B homozygotes had lower levels of MHC class I expressed on the surface of B cells, suggesting that naturally occurring ERAP2 deficiency affects MHC presentation and immune response.
Positive_regulation (levels) of MHC in B cells
16) Confidence 0.24 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2954825 Disease Relevance 0 Pain Relevance 0
Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region.
Positive_regulation (segment) of MHC in leukocyte
17) Confidence 0.23 Published 1999 Journal J. Immunol. Section Title Doc Link 10384126 Disease Relevance 0.27 Pain Relevance 0.05
Although induction of MHC class I and Class II was observed on IFN?
Positive_regulation (induction) of MHC
18) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0.33 Pain Relevance 0.20
Several MHC-I and MHC-II transmembrane receptors were upregulated after the 6 h exposure.
Positive_regulation (upregulated) of MHC
19) Confidence 0.12 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.24 Pain Relevance 0
Several MHC-I and MHC-II transmembrane receptors were upregulated after the 6 h exposure.
Positive_regulation (upregulated) of MHC
20) Confidence 0.12 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.24 Pain Relevance 0

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