INT15798

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.46
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.99
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (TFRC) peptidase activity (TFRC) mitochondrion (TFRC)
aging (TFRC) extracellular region (TFRC) cytoplasmic membrane-bounded vesicle (TFRC)
Anatomy Link Frequency
macrophages 3
monocytes 3
lymphocytes 2
NK cells 2
TFRC (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 32 99.26 Very High Very High Very High
qutenza 33 96.56 Very High Very High Very High
Cluster headache 4 94.80 High High
Versed 2 93.44 High High
Morphine 1 90.52 High High
cytokine 24 87.44 High High
Opioid 1 86.80 High High
Inflammatory stimuli 2 81.28 Quite High
chemokine 3 69.52 Quite High
Electroencephalography 19 68.28 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 32 99.26 Very High Very High Very High
Pulmonary Alveolar Proteinosis 207 98.04 Very High Very High Very High
Cluster Headache 4 94.80 High High
Ataxia 24 93.76 High High
Infection 17 91.64 High High
Stress 67 86.92 High High
Injury 9 86.40 High High
Iron Overload 27 82.68 Quite High
Muscle Disease 9 82.40 Quite High
Obesity 22 76.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, we studied the expression of Leu-4, specific for T-cells; of Leu-11b, specific for FC receptor on NK cells; and the Transferrin Receptor, specific for lymphoblasts and monocytes.
Positive_regulation (specific) of Gene_expression (expression) of Transferrin Receptor in NK cells
1) Confidence 0.46 Published 1990 Journal Headache Section Abstract Doc Link 2335478 Disease Relevance 0.32 Pain Relevance 0.32
BE did not increase the amount of class II MHC antigens on monocytes and did not preferentially stimulate CD69, CD25 and CD71 antigen expression on either CD4+ or CD8+ lymphocytes.
Neg (not) Positive_regulation (stimulate) of Gene_expression (expression) of CD71 in lymphocytes
2) Confidence 0.32 Published 1991 Journal J. Biol. Regul. Homeost. Agents Section Abstract Doc Link 1763657 Disease Relevance 0 Pain Relevance 0.09
A very similar oscillatory response appeared also in the total TFR, which we label TR I (total response I, t(15) = ?
Positive_regulation (response) of Gene_expression (label) of TFR
3) Confidence 0.31 Published 2009 Journal Journal of pain research Section Body Doc Link PMC3004625 Disease Relevance 0.05 Pain Relevance 0.24
Alterations in iron metabolism were evidenced by elevations in both concentrations of iron and levels of transferrin, transferrin receptor, lactoferrin, and ferritin in all patients with PAP.
Positive_regulation (elevations) of Gene_expression (levels) of transferrin receptor associated with pulmonary alveolar proteinosis
4) Confidence 0.24 Published 2008 Journal Respir Res Section Body Doc Link PMC2265287 Disease Relevance 1.04 Pain Relevance 0
UTR and increase the rate of synthesis of iron uptake proteins such as TfR1.
Positive_regulation (increase) of Gene_expression (synthesis) of TfR1
5) Confidence 0.23 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.79 Pain Relevance 0
However, with elevations in available iron observed during inflammation, monocytes and macrophages actually increase TfR expression [42,43].
Positive_regulation (increase) of Gene_expression (expression) of TfR in macrophages associated with inflammation
6) Confidence 0.22 Published 2008 Journal Respir Res Section Body Doc Link PMC2265287 Disease Relevance 1.07 Pain Relevance 0.14
Furthermore, the expression of a variety of drug transporters (ABCB1, ABCG2, ABCC1-5) as well as the human transferrin receptor was demonstrated on the mRNA level.
Positive_regulation (demonstrated) of Gene_expression (expression) of transferrin receptor
7) Confidence 0.12 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 19013850 Disease Relevance 0 Pain Relevance 0.14
Human leptin was found to stimulate proliferation and activation of human circulating monocytes in vitro, promoting the expression of activation markers: CD69, CD25, CD38, and CD71, in addition to increasing the expression of monocytes surface markers, such as HLA-DR, CD11b, and CD11c [24].
Positive_regulation (promoting) of Gene_expression (expression) of CD71 in monocytes
8) Confidence 0.08 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0.64 Pain Relevance 0.36
However, with elevations in available iron observed during inflammation, monocytes and macrophages actually increase TfR expression [42,43].
Positive_regulation (increase) of in monocytes Gene_expression (expression) of TfR in macrophages associated with inflammation
9) Confidence 0.08 Published 2008 Journal Respir Res Section Body Doc Link PMC2265287 Disease Relevance 1.07 Pain Relevance 0.14

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox