INT157982

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp2b2) aging (Cyp2b2) endoplasmic reticulum (Cyp2b2)
Cyp2b2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
sSRI 6 99.56 Very High Very High Very High
Desipramine 4 98.32 Very High Very High Very High
antidepressant 7 97.52 Very High Very High Very High
fluoxetine 3 86.40 High High
Serotonin 1 85.12 High High
noradrenaline 1 76.48 Quite High
Endep 1 58.20 Quite High
tricyclic antidepressant 1 39.48 Quite Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, two different mechanisms of the antidepressant-CYP2B interaction are postulated: 1) a direct inhibition of CYP2B shown in vitro by nefazodone, SSRIs and TADs; 2) in vivo induction of CYP2B produced by prolonged administration of SSRIs and desipramine, which suggests their influence on enzyme regulation.
Positive_regulation (induction) of Gene_expression (produced) of CYP2B associated with desipramine, antidepressant and ssri
1) Confidence 0.43 Published 2008 Journal Pharmacol Rep Section Abstract Doc Link 19211989 Disease Relevance 0 Pain Relevance 0.85

General Comments

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