INT15799

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.38
First Reported 1991
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 9.78
Pain Relevance 2.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ISG20) nucleoplasm (ISG20) RNA binding (ISG20)
nucleus (ISG20) intracellular (ISG20)
Anatomy Link Frequency
regulatory T cells 7
blood 1
neuronal 1
lymphocytes 1
lymphoid tissues 1
ISG20 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 193 96.56 Very High Very High Very High
rheumatoid arthritis 65 94.76 High High
Inflammation 224 94.64 High High
Arthritis 126 94.04 High High
chemokine 51 93.20 High High
corticosteroid 16 88.60 High High
methotrexate 21 87.88 High High
Opioid 1 84.56 Quite High
Pain 2 83.44 Quite High
tolerance 70 72.48 Quite High
Disease Link Frequency Relevance Heat
Fever 14 99.60 Very High Very High Very High
Disease 176 99.40 Very High Very High Very High
Mucocutaneous Lymph Node Syndrome 14 99.04 Very High Very High Very High
Cancer 184 98.12 Very High Very High Very High
Necrosis 13 96.44 Very High Very High Very High
Rheumatoid Arthritis 66 94.76 High High
Sjoegrens Syndrome 14 94.68 High High
INFLAMMATION 224 94.64 High High
Juvenile Chronic Polyarthritis 112 94.04 High High
Infection 56 92.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BE did not increase the amount of class II MHC antigens on monocytes and did not preferentially stimulate CD69, CD25 and CD71 antigen expression on either CD4+ or CD8+ lymphocytes.
Neg (not) Positive_regulation (stimulate) of CD25 in lymphocytes
1) Confidence 0.38 Published 1991 Journal J. Biol. Regul. Homeost. Agents Section Abstract Doc Link 1763657 Disease Relevance 0 Pain Relevance 0.08
Circulating blasts were positive for CD4, CD7, CD25, CD13, CD33, CD34, and HLA-DR and partly positive for CD41 and CD36.
Positive_regulation (positive) of CD25
2) Confidence 0.30 Published 1995 Journal Rinsho Ketsueki Section Abstract Doc Link 8531333 Disease Relevance 0.51 Pain Relevance 0.08
Tregs express high levels of surface antigens such as CD25, cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), and glucocorticoid-induced tumor necrosis factor receptor (GITR) [23,24].
Positive_regulation (levels) of CD25 in cytotoxic T lymphocyte associated with necrosis and cancer
3) Confidence 0.18 Published 2010 Journal J Transl Med Section Body Doc Link PMC2936304 Disease Relevance 0.78 Pain Relevance 0
In Kawasaki disease, Furuno et al. found that during the active phase of the disease, the number of circulating CD4+CD25high regulatory T cells is reduced compared to patients with infectious causes of febrile illness, whose CD4+CD25high regulatory T cell numbers are higher than in healthy subjects.
Positive_regulation (regulatory T cell) of CD25high in regulatory T cell associated with mucocutaneous lymph node syndrome, fever and disease
4) Confidence 0.18 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 1.18 Pain Relevance 0.08
In Kawasaki disease, Furuno et al. found that during the active phase of the disease, the number of circulating CD4+CD25high regulatory T cells is reduced compared to patients with infectious causes of febrile illness, whose CD4+CD25high regulatory T cell numbers are higher than in healthy subjects.
Positive_regulation (regulatory T cells) of CD25high in regulatory T cell associated with mucocutaneous lymph node syndrome, fever and disease
5) Confidence 0.18 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 1.17 Pain Relevance 0.09
Studies from our laboratory showed that circulating CD4+CD25high CD127lo/- regulatory T cell numbers are normal, but their in vitro suppressive function is lower than that of healthy controls (unpublished data).
Positive_regulation (circulating) of CD25high in regulatory T cell
6) Confidence 0.18 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 0.70 Pain Relevance 0.31
These include decreased density, upregulation of surface activation molecules (e.g., CD69, CD25, CD44, and HLA-DR), enhanced cellular cytotoxicity, and release of granule proteins, cytokines, leukotrienes, and other mediators of inflammation (reviewed in [25]).
Positive_regulation (upregulation) of CD25 associated with inflammation and cytokine
7) Confidence 0.17 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.77 Pain Relevance 0.20
treated CD4+CD25?
Positive_regulation (treated) of CD25
8) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0 Pain Relevance 0.07
In defervesce phase of the disease, the number of CD4+CD25high regulatory T cells in patients with Kawasaki disease increases to/or above normal levels, while CD4+CD25high regulatory T cells in patients with infectious febrile disease decrease to normal levels [138].
Positive_regulation (regulatory T cells) of CD25high in regulatory T cells associated with mucocutaneous lymph node syndrome, fever and disease
9) Confidence 0.15 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 1.24 Pain Relevance 0.07
However, the ratio of CD4+CD25high regulatory T cells to IFN-?
Positive_regulation (regulatory T cells) of CD25high in regulatory T cells
10) Confidence 0.15 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 0.82 Pain Relevance 0.37
Therefore, a major therapeutic effect of rapamycin may be the induction of tolerogenic CD4+CD25high regulatory T cells in vivo.
Positive_regulation (induction) of CD25high in regulatory T cells
11) Confidence 0.15 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 0.33 Pain Relevance 0.19
Firstly, there are likely to be differences in the specific role of CD4+CD25high regulatory T cells in particular diseases, and these must be elucidated.
Positive_regulation (regulatory T cells) of CD25high in regulatory T cells associated with disease
12) Confidence 0.15 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 0.41 Pain Relevance 0
Compared with healthy patients, patients with gastrointestinal malignancies had a higher proportion of CD4+ CD25+ T-cells in peripheral blood [71].
Positive_regulation (proportion) of CD25 in blood
13) Confidence 0.15 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2821644 Disease Relevance 0.66 Pain Relevance 0.10
Since then, scientists have determined that IL-16 has a wide range of effects on cells, including upregulation of CD25, induction of cells to progress to the G(1) phase, inhibition of antigen- specific proliferation yet with retained antigen nonspecific proliferative properties, and discovery of a novel neuronal form with unique properties.
Positive_regulation (upregulation) of CD25 in neuronal
14) Confidence 0.10 Published 2006 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 16881862 Disease Relevance 0.55 Pain Relevance 0.31
CD25+, was markedly increased in TLT as compared with the 2 canonical lymphoid tissues.
Positive_regulation (increased) of CD25 in lymphoid tissues
15) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894881 Disease Relevance 0 Pain Relevance 0
Treatment of YT cells with Trx1(CCAAA) (but not with redox-inactive Trx1) prevented CD25 upregulation (Figure 7A, lower panel, columns 5 and 8), concomitant with the redox change in CD30 (Figure 7A, upper panel, column 4), thus demonstrating that the redox interaction between Trx1 and CD30 has a pronounced influence on CD30-mediated gene expression.
Positive_regulation (upregulation) of CD25 in upper
16) Confidence 0.10 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.08 Pain Relevance 0.03
Compared to the PBMNC, which were obtained before the start of the therapy, the CD3- NK cells exhibited an increased density of activatory NK cell markers such as CD94/NKG2C, CD16/CD56, NKG2D, CD25 and the NCRs NKp30, NKp44, NKp46, although the absolute number of NK cells remained unaffected.
Positive_regulation (increased) of CD25 in NK cells
17) Confidence 0.09 Published 2009 Journal J Transl Med Section Body Doc Link PMC2714296 Disease Relevance 0.40 Pain Relevance 0
0.0011 for both), activation markers CD69 and CD25 (P?
Positive_regulation (activation) of CD25
18) Confidence 0.08 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.18 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox