INT158

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.81
First Reported 1971
Last Reported 2010
Negated 9
Speculated 30
Reported most in Abstract
Documents 2431
Total Number 2461
Disease Relevance 378.96
Pain Relevance 952.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Prl)
Anatomy Link Frequency
pituitary 198
anterior pituitary 59
plasma 44
hypothalamus 42
brain 38
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 4356 100.00 Very High Very High Very High
narcan 2791 100.00 Very High Very High Very High
Morphine 2226 100.00 Very High Very High Very High
gABA 1735 100.00 Very High Very High Very High
Opioid 1604 100.00 Very High Very High Very High
Glutamate 1434 100.00 Very High Very High Very High
Serotonin 1363 100.00 Very High Very High Very High
Neurotransmitter 1166 100.00 Very High Very High Very High
Enkephalin 950 100.00 Very High Very High Very High
Neuropeptide 741 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 6706 100.00 Very High Very High Very High
Galactorrhea 831 100.00 Very High Very High Very High
Adenoma 709 100.00 Very High Very High Very High
Prolactinoma 663 100.00 Very High Very High Very High
Obesity 494 100.00 Very High Very High Very High
Acromegaly 66 100.00 Very High Very High Very High
Cluster Headache 39 100.00 Very High Very High Very High
Post Operative Pain 4 100.00 Very High Very High Very High
Reprotox - General 1 382 99.98 Very High Very High Very High
Cancer 3094 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After the initial 'surge' of Prl secretion, which lasted about 15 min, the concentration returned to normal levels.
Localization (secretion) of Prl
1) Confidence 0.81 Published 1978 Journal Neuroendocrinology Section Abstract Doc Link 683470 Disease Relevance 0 Pain Relevance 0.10
The effect of exposure to ether on prolactin secretion and the half-life of endogenous prolactin in normal and castrated male rats.
Localization (secretion) of prolactin
2) Confidence 0.81 Published 1978 Journal Neuroendocrinology Section Title Doc Link 683470 Disease Relevance 0 Pain Relevance 0.08
Although neither haloperidol nor morphine increased the release of PRL from the isolated anterior pituitary, haloperidol, but not morphine, reversed the inhibition by dopamine of the in vitro release of pituitary PRL.
Localization (release) of PRL in pituitary associated with dopamine and morphine
3) Confidence 0.81 Published 1978 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 745306 Disease Relevance 0 Pain Relevance 1.28
Effects of morphine on the serum prolactin levels of morphine-tolerant and nontolerant male rats and of the in vitro release of pituitary prolactin.
Localization (release) of prolactin in pituitary associated with narcan and morphine
4) Confidence 0.81 Published 1978 Journal Jpn. J. Pharmacol. Section Title Doc Link 745306 Disease Relevance 0 Pain Relevance 1.26
Although neither haloperidol nor morphine increased the release of PRL from the isolated anterior pituitary, haloperidol, but not morphine, reversed the inhibition by dopamine of the in vitro release of pituitary PRL.
Localization (release) of PRL in pituitary associated with dopamine and morphine
5) Confidence 0.81 Published 1978 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 745306 Disease Relevance 0 Pain Relevance 1.31
In this experiment, the PRL release evoked by administration of estrogen, which is another principal stimulus for PRL release, was examined in ovariectomized lactating rats 8-15 days after delivery.
Localization (release) of PRL
6) Confidence 0.81 Published 1992 Journal Neuroendocrinology Section Abstract Doc Link 1407378 Disease Relevance 0.19 Pain Relevance 0
In this experiment, the PRL release evoked by administration of estrogen, which is another principal stimulus for PRL release, was examined in ovariectomized lactating rats 8-15 days after delivery.
Spec (examined) Localization (release) of PRL
7) Confidence 0.81 Published 1992 Journal Neuroendocrinology Section Abstract Doc Link 1407378 Disease Relevance 0.19 Pain Relevance 0
There are data indicating that stress-induced prolactin (PRL) release is blunted in the lactating rat like the release of other stress-associated hormones.
Localization (release) of PRL associated with stress
8) Confidence 0.81 Published 1992 Journal Neuroendocrinology Section Abstract Doc Link 1407378 Disease Relevance 0.20 Pain Relevance 0
There are data indicating that stress-induced prolactin (PRL) release is blunted in the lactating rat like the release of other stress-associated hormones.
Localization (release) of prolactin associated with stress
9) Confidence 0.81 Published 1992 Journal Neuroendocrinology Section Abstract Doc Link 1407378 Disease Relevance 0.20 Pain Relevance 0
The experiment examining pituitary PRL concentration at 6:00 or 18:00 hr confirmed that urethane (1.0g/kg) anesthesia suppressed the release of PRL surge from the pituitary.
Localization (release) of PRL in pituitary associated with anesthesia
10) Confidence 0.81 Published 1991 Journal Jikken Dobutsu Section Abstract Doc Link 2007438 Disease Relevance 0 Pain Relevance 0.25
Role of serotonin in opiate-induced prolactin secretion and antinociception in the developing rat.
Localization (secretion) of prolactin associated with pain, antinociception, opiate and serotonin
11) Confidence 0.81 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 2435887 Disease Relevance 0 Pain Relevance 1.11
The present study tests the hypothesis that opiates stimulate PRL secretion through a serotonergic mechanism in adult rats, but a nonserotonergic mechanism in neonatal rats.
Localization (secretion) of PRL associated with opiate
12) Confidence 0.81 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2435887 Disease Relevance 0 Pain Relevance 0.81
Our laboratory has demonstrated previously that the ability of opiates to stimulate prolactin (PRL) release during ontogeny precedes the appearance of a PRL response to serotonergic drugs.
Localization (release) of prolactin associated with opiate
13) Confidence 0.81 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2435887 Disease Relevance 0 Pain Relevance 0.71
Morphine stimulated PRL secretion in adult and neonatal (10-day-old) rats and this increase was blocked with the opiate antagonist naloxone.
Localization (secretion) of PRL associated with antagonist, narcan, opiate and morphine
14) Confidence 0.81 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2435887 Disease Relevance 0 Pain Relevance 1.00
Our laboratory has demonstrated previously that the ability of opiates to stimulate prolactin (PRL) release during ontogeny precedes the appearance of a PRL response to serotonergic drugs.
Localization (release) of PRL associated with opiate
15) Confidence 0.81 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2435887 Disease Relevance 0 Pain Relevance 0.71
Prolactin secretion and its response to stress during the estrous cycle of the rats.
Localization (secretion) of Prolactin associated with stress and anesthesia
16) Confidence 0.81 Published 1989 Journal Jikken Dobutsu Section Title Doc Link 2806389 Disease Relevance 0.10 Pain Relevance 0.32
From these results, the following conclusions were drawn: 1) the PRL surge on the afternoon of proestrus occurs without synthesis of the hormone in the pituitary; 2) PRL secretion on the afternoon of estrus is accompanied by its synthesis in the gland; 3) the PRL response is distinct for each type of stress applied; and 4) PRL secretion is thus regulated by different mechanisms in proestrus and estrus.
Localization (secretion) of PRL in gland associated with stress
17) Confidence 0.81 Published 1989 Journal Jikken Dobutsu Section Abstract Doc Link 2806389 Disease Relevance 0.17 Pain Relevance 0.25
From these results, the following conclusions were drawn: 1) the PRL surge on the afternoon of proestrus occurs without synthesis of the hormone in the pituitary; 2) PRL secretion on the afternoon of estrus is accompanied by its synthesis in the gland; 3) the PRL response is distinct for each type of stress applied; and 4) PRL secretion is thus regulated by different mechanisms in proestrus and estrus.
Localization (secretion) of PRL in gland associated with stress
18) Confidence 0.81 Published 1989 Journal Jikken Dobutsu Section Abstract Doc Link 2806389 Disease Relevance 0.17 Pain Relevance 0.23
The occurrence of a surge in PRL secretion during proestrus was confirmed with a peak at 1500 h, and this was accompanied by a decline in pituitary PRL content.
Localization (secretion) of PRL in pituitary
19) Confidence 0.81 Published 1989 Journal Jikken Dobutsu Section Abstract Doc Link 2806389 Disease Relevance 0.07 Pain Relevance 0.24
The effect of morphine administration on the subsequent stimulation of prolactin (PRL) secretion and the release of dopamine from tuberoinfundibular neurons was examined in this study.
Localization (secretion) of PRL in neurons associated with dopamine and morphine
20) Confidence 0.81 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3950867 Disease Relevance 0.15 Pain Relevance 0.61

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox