INT15800

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Context Info
Confidence 0.43
First Reported 1991
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 9.28
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 4
macrophages 1
lymphocytes 1
NK cells 1
lung 1
CD69 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 219 97.76 Very High Very High Very High
cytokine 216 96.32 Very High Very High Very High
rheumatoid arthritis 81 85.44 High High
Opioid 1 84.08 Quite High
agonist 11 82.80 Quite High
Angina 1 80.40 Quite High
Multiple sclerosis 1 72.08 Quite High
visual analogue scale 1 61.60 Quite High
Pain 5 59.80 Quite High
ischemia 1 44.96 Quite Low
Disease Link Frequency Relevance Heat
Pulmonary Disease 174 99.54 Very High Very High Very High
Nicotine Addiction 182 98.84 Very High Very High Very High
Death 20 98.32 Very High Very High Very High
Apoptosis 24 98.00 Very High Very High Very High
INFLAMMATION 260 97.76 Very High Very High Very High
Hypersensitivity 75 96.20 Very High Very High Very High
Infection 122 92.80 High High
Rheumatoid Arthritis 81 85.44 High High
Influenza Virus Infection 2 85.44 High High
Communicable Diseases 23 83.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BE did not increase the amount of class II MHC antigens on monocytes and did not preferentially stimulate CD69, CD25 and CD71 antigen expression on either CD4+ or CD8+ lymphocytes.
Neg (not) Positive_regulation (stimulate) of CD69 in lymphocytes
1) Confidence 0.43 Published 1991 Journal J. Biol. Regul. Homeost. Agents Section Abstract Doc Link 1763657 Disease Relevance 0 Pain Relevance 0.08
CD69, an early activation marker on T cells, was not changed upon co-culture with BMMSCs and WJMSCs except for TNF?
Neg (not) Positive_regulation (changed) of CD69 in T cells
2) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0.14 Pain Relevance 0.22
Induction of the CD69 activation marker on Natural Killer cells
Positive_regulation (Induction) of CD69
3) Confidence 0.34 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2858026 Disease Relevance 0.18 Pain Relevance 0.05
In addition to the standard T-lymphocyte markers CD3, CD4, CD8, markers of T-cell activation CD25, CD69 and proliferation CD71 were assayed described earlier [34].


Positive_regulation (activation) of CD69 in T-cell
4) Confidence 0.32 Published 2006 Journal Retrovirology Section Body Doc Link PMC1590049 Disease Relevance 0.12 Pain Relevance 0.09
T cell surface molecules, some of them upregulated on activation, such as CD69 [2,3], CD23 [4,5], integrins [6], CD40-CD40 ligand [7], LAG-3 [8], CD45 [9], LFA-1 and ICAM-1 [10] and membrane-bound cytokines [11] have all been implicated in this activation.
Positive_regulation (upregulated) of CD69 in T cell associated with cytokine
5) Confidence 0.27 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297564 Disease Relevance 1.00 Pain Relevance 0.42
Also, CD69 median fluorescence intensity was increased on CD8+ T cells in COPD subjects and smokers with normal lung function compared to never-smokers (p = 0.007 and p = 0.001 respectively) (figure 5).
Positive_regulation (increased) of CD69 in T cells associated with nicotine addiction and pulmonary disease
6) Confidence 0.26 Published 2010 Journal Respir Res Section Body Doc Link PMC2955660 Disease Relevance 2.22 Pain Relevance 0.03
Induction of the CD69 activation marker on Natural Killer cells
Positive_regulation (Induction) of CD69
7) Confidence 0.24 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2858026 Disease Relevance 0.18 Pain Relevance 0.05
Both fractions induced the CD69 activation marker on human CD3-negative, CD56-positive NK cells, and also enhanced the transient expression of CD107a as an indication of increased NK cell cytotoxicity in the presence of transformed cells.
Positive_regulation (induced) of CD69 in NK cells
8) Confidence 0.24 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2858026 Disease Relevance 0.16 Pain Relevance 0.07
0.0011 for both), activation markers CD69 and CD25 (P?
Positive_regulation (activation) of CD69
9) Confidence 0.24 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.18 Pain Relevance 0
These include decreased density, upregulation of surface activation molecules (e.g., CD69, CD25, CD44, and HLA-DR), enhanced cellular cytotoxicity, and release of granule proteins, cytokines, leukotrienes, and other mediators of inflammation (reviewed in [25]).
Positive_regulation (upregulation) of CD69 associated with inflammation and cytokine
10) Confidence 0.22 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.77 Pain Relevance 0.20
Radioimmunoassays previously used mainly for the diagnosis of penicillin allergy (including the radioallergosorbent test, RAST) have over the years been replaced with the FEIA assays.16,17 Flow-cytometric based basophil activation tests (BAT) (flow assay stimulation test, FAST/FlowCAST®, Buhlmann Laboratories) which measure CD69 or CD203c on drug-specific activated basophils may have a role in the diagnosis of antibiotic allergy, with studies so far mainly focused on beta-lactam allergy.18
Positive_regulation (measure) of CD69 in basophils associated with hypersensitivity
11) Confidence 0.20 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846744 Disease Relevance 0.54 Pain Relevance 0
In addition, we now report that the cytotoxic T cells in BALF of smokers with normal lung function and COPD patients express high levels of the co-stimulatory receptor NKG2 D and the early cell activation marker CD69.
Positive_regulation (levels) of CD69 in lung associated with pulmonary disease and nicotine addiction
12) Confidence 0.18 Published 2010 Journal Respir Res Section Body Doc Link PMC2955660 Disease Relevance 1.47 Pain Relevance 0
In comparison with other ligands that can trigger the lysis of macrophages, including complement-mediated cytolysis, Fas ligation and CD69 activation, only ATPe treatment could stimulate the death of both host macrophages and intracellular mycobacteria.
Positive_regulation (activation) of CD69 in macrophages associated with death
13) Confidence 0.12 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096763 Disease Relevance 1.09 Pain Relevance 0.03
In NSTEMI patients we found a significant increase of HLADR+ CD3+ and CD69+CD4+ cells.
Positive_regulation (increase) of CD69
14) Confidence 0.08 Published 2003 Journal Clin. Exp. Med. Section Abstract Doc Link 12748878 Disease Relevance 1.05 Pain Relevance 0.19
This hypothesis of lowered activation was reinforced by the 66% decrease of the mRNA level of early activation surface markers CD69 found in comparison with healthy aged subjects (Table 2).
Positive_regulation (activation) of CD69
15) Confidence 0.07 Published 2010 Journal Immun Ageing Section Body Doc Link PMC2933667 Disease Relevance 0.17 Pain Relevance 0

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