INT158000

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Context Info
Confidence 0.21
First Reported 2002
Last Reported 2009
Negated 2
Speculated 3
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 0.20
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (APLNR) nucleus (APLNR) signal transducer activity (APLNR)
APLNR (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 14 100.00 Very High Very High Very High
opioid receptor 4 99.54 Very High Very High Very High
Neuropeptide 61 96.72 Very High Very High Very High
Central nervous system 1 96.48 Very High Very High Very High
chemokine 53 95.80 Very High Very High Very High
adenocard 9 95.80 Very High Very High Very High
Serotonin 19 83.96 Quite High
Cannabinoid 2 67.68 Quite High
agonist 15 59.08 Quite High
Dopamine 11 44.40 Quite Low
Disease Link Frequency Relevance Heat
Ovarian Cancer 2 81.84 Quite High
Targeted Disruption 1 64.16 Quite High
Alzheimer's Dementia 6 51.40 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 9 45.80 Quite Low
Disease 18 30.12 Quite Low
Schizophrenia 2 29.16 Quite Low
Attention Deficit Hyperactivity Disorder 2 28.56 Quite Low
Depression 2 27.44 Quite Low
Pellagra 2 23.28 Low Low
Adhesions 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We hypothesize that the orphan receptor CKRX, which constitutes a separate branch related to CKR1, 2, 3 and 5, might also bind a CC ligand.
orphan receptor Spec (might) Binding (bind) of
1) Confidence 0.21 Published 2002 Journal Genome Biol Section Body Doc Link PMC133447 Disease Relevance 0 Pain Relevance 0.17
The orphan receptor ML1X is closely related to melatonin receptors ML1A and B, but apparently does not bind melatonin [48].
orphan receptor Neg (not) Binding (bind) of
2) Confidence 0.16 Published 2002 Journal Genome Biol Section Body Doc Link PMC133447 Disease Relevance 0.05 Pain Relevance 0.08
Group A2 is more heterogeneous and comprises receptors for CC and CXC ligands, as well as an orphan receptor (ADMR) previously thought to bind the peptide adrenomedullin.
orphan receptor Binding (bind) of
3) Confidence 0.14 Published 2002 Journal Genome Biol Section Body Doc Link PMC133447 Disease Relevance 0 Pain Relevance 0.14
Drosophila orphan receptor Q9VVJ1_Dro within this tree might bind to ligands derived from AA by the action of COX.
orphan receptor Spec (might) Binding (bind) of
4) Confidence 0.01 Published 2005 Journal BMC Genomics Section Body Doc Link PMC1192796 Disease Relevance 0.08 Pain Relevance 0.03
Drosophila orphan receptor Q9VHW1_Dro branch out along with muscarinic acetylcholine and histamine receptors in this tree and might bind to acetylcholine or histamines for its activation.
orphan receptor Spec (might) Binding (bind) of
5) Confidence 0.01 Published 2005 Journal BMC Genomics Section Body Doc Link PMC1192796 Disease Relevance 0 Pain Relevance 0.25
Originally mischaracterized as an opioid receptor, the sigma-1 receptor binds a vast number of synthetic compounds but does not bind opioid peptides; it is currently considered an orphan receptor.
orphan receptor Neg (not) Binding (binds) of associated with opioid receptor and opioid
6) Confidence 0.00 Published 2009 Journal Science Section Abstract Doc Link 19213917 Disease Relevance 0.06 Pain Relevance 0.23

General Comments

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