INT15801

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Context Info
Confidence 0.33
First Reported 1991
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 6.35
Pain Relevance 3.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (TFRC) peptidase activity (TFRC) mitochondrion (TFRC)
aging (TFRC) extracellular region (TFRC) cytoplasmic membrane-bounded vesicle (TFRC)
Anatomy Link Frequency
spinal cord 1
neurons 1
lymphocytes 1
lung 1
nociceptors 1
TFRC (Homo sapiens)
Pain Link Frequency Relevance Heat
nociceptor 66 100.00 Very High Very High Very High
Spinal cord 9 100.00 Very High Very High Very High
c fibre 58 99.42 Very High Very High Very High
Pain 81 98.04 Very High Very High Very High
Inflammation 40 98.04 Very High Very High Very High
qutenza 66 96.80 Very High Very High Very High
Buprenorphine 6 95.80 Very High Very High Very High
opioid receptor 6 94.88 High High
agonist 4 93.60 High High
Opioid 1 85.28 High High
Disease Link Frequency Relevance Heat
Pulmonary Alveolar Proteinosis 276 100.00 Very High Very High Very High
Nociception 12 100.00 Very High Very High Very High
Pancreatitis 12 99.84 Very High Very High Very High
Pain 73 98.04 Very High Very High Very High
INFLAMMATION 33 98.04 Very High Very High Very High
Stress 84 97.80 Very High Very High Very High
Injury 12 94.12 High High
Disease 56 92.88 High High
Increased Venous Pressure Under Development 4 90.32 High High
Hematological Disease 4 88.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A novel aspect of our data is the finding that TfR in PAP lavage fluid is increased despite elevated soluble iron levels in the lung.
Positive_regulation (increased) of TfR in lung associated with pulmonary alveolar proteinosis
1) Confidence 0.33 Published 2008 Journal Respir Res Section Body Doc Link PMC2265287 Disease Relevance 0.89 Pain Relevance 0.12
Yet, desensitization of polymodal A-nociceptors may have contributed to the reduction of the evoked delta power (ER I of evoked TFR) and N2–P2 amplitude of the LEP whereas sensitization of polymodal C-nociceptors may have contributed to the enhancement of the TR III in the total TFR.
Positive_regulation (enhancement) of TFR in nociceptors associated with c fibre and nociceptor
2) Confidence 0.31 Published 2009 Journal Journal of pain research Section Body Doc Link PMC3004625 Disease Relevance 0.22 Pain Relevance 1.51
A very similar oscillatory response appeared also in the total TFR, which we label TR I (total response I, t(15) = ?
Positive_regulation (total) of TFR
3) Confidence 0.31 Published 2009 Journal Journal of pain research Section Body Doc Link PMC3004625 Disease Relevance 0.05 Pain Relevance 0.24
S cluster, IRP1 is activated to become an IRE-binding protein, which increases the rate of cellular iron uptake and decreases the rate of iron sequestration by stabilizing TfR1 mRNA and repressing ferritin synthesis.
Positive_regulation (stabilizing) of TfR1
4) Confidence 0.23 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.08 Pain Relevance 0
Alterations in iron metabolism were evidenced by elevations in both concentrations of iron and levels of transferrin, transferrin receptor, lactoferrin, and ferritin in all patients with PAP.
Positive_regulation (elevations) of transferrin receptor associated with pulmonary alveolar proteinosis
5) Confidence 0.22 Published 2008 Journal Respir Res Section Body Doc Link PMC2265287 Disease Relevance 1.04 Pain Relevance 0
Increased TfR in the BAL of PAP patients may reflect a defensive attempt to transport and sequester elevated concentrations of metal that occur in inflammatory injuries.


Positive_regulation (Increased) of TfR associated with inflammation, pulmonary alveolar proteinosis and injury
6) Confidence 0.22 Published 2008 Journal Respir Res Section Body Doc Link PMC2265287 Disease Relevance 1.10 Pain Relevance 0.14
In addition to the standard T-lymphocyte markers CD3, CD4, CD8, markers of T-cell activation CD25, CD69 and proliferation CD71 were assayed described earlier [34].


Positive_regulation (activation) of CD71 in T-cell
7) Confidence 0.16 Published 2006 Journal Retrovirology Section Body Doc Link PMC1590049 Disease Relevance 0.12 Pain Relevance 0.09
BE did not increase the amount of class II MHC antigens on monocytes and did not preferentially stimulate CD69, CD25 and CD71 antigen expression on either CD4+ or CD8+ lymphocytes.
Neg (not) Positive_regulation (stimulate) of CD71 in lymphocytes
8) Confidence 0.14 Published 1991 Journal J. Biol. Regul. Homeost. Agents Section Abstract Doc Link 1763657 Disease Relevance 0 Pain Relevance 0.09
Lavage concentrations of iron, transferrin, transferrin receptor, lactoferrin, and ferritin were significantly elevated in PAP patients relative to healthy volunteers.
Positive_regulation (elevated) of transferrin receptor associated with pulmonary alveolar proteinosis
9) Confidence 0.10 Published 2008 Journal Respir Res Section Abstract Doc Link PMC2265287 Disease Relevance 1.40 Pain Relevance 0
Cerulein-induced acute pancreatitis in rat increases visceral nociceptive signaling at spinal cord levels T9 and T10, with a peak at 6 h.
Positive_regulation (increases) of T9 in spinal cord associated with nociception, pancreatitis and spinal cord
10) Confidence 0.03 Published 2004 Journal J. Surg. Res. Section Abstract Doc Link 15047123 Disease Relevance 0.58 Pain Relevance 0.65
Activation of nociceptive neurons in T9 and T10 in cerulein pancreatitis.
Positive_regulation (Activation) of T9 in neurons associated with nociception, nociceptor and pancreatitis
11) Confidence 0.03 Published 2004 Journal J. Surg. Res. Section Title Doc Link 15047123 Disease Relevance 0.77 Pain Relevance 0.46
With regard to genes involved in iron metabolism, ferritin and iron storage proteins were upregulated in FePro-labeled BMSCs and transferrin receptor was not changed.


Positive_regulation (upregulated) of transferrin receptor
12) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2898800 Disease Relevance 0.09 Pain Relevance 0

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