INT158014

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Context Info
Confidence 0.27
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.90
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (FLT1, PGF) extracellular region (FLT1, PGF) endosome (FLT1)
Golgi apparatus (FLT1) cell-cell signaling (PGF) cytoplasm (FLT1)
Anatomy Link Frequency
placenta 2
FLT1 (Homo sapiens)
PGF (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 1 99.08 Very High Very High Very High
Clonidine 1 73.76 Quite High
ischemia 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Eclampsia 5 99.60 Very High Very High Very High
Fibromyalgia 5 95.28 Very High Very High Very High
Pre-eclampsia 39 80.32 Quite High
Lipoid Nephrosis 4 75.72 Quite High
Hypertension 6 75.00 Quite High
Disease 8 10.56 Low Low
Proteinuria 4 5.00 Very Low Very Low Very Low
Birth Weight 3 5.00 Very Low Very Low Very Low
Syndrome 3 5.00 Very Low Very Low Very Low
Genetic Predisposition To Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Soluble Flt-1 binds to circulating free vascular endothelial growth factor and placenta growth factor and this is associated with endothelial dysfunction.
Flt-1 Binding (binds) of placenta growth factor in placenta
1) Confidence 0.27 Published 2009 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 19215236 Disease Relevance 0.34 Pain Relevance 0.07
Most of the Flt-1 produced in the mouse and human placenta during later stages of gestation is the soluble form (sFlt-1) generated by alternative splicing of Flt-1, leading to a premature termination after the sixth Ig-like domain [30]. sFlt-1 binds both VEGF and PlGF and acts as a soluble antagonist of their action.
sFlt-1 Binding (binds) of PlGF in placenta associated with antagonist
2) Confidence 0.21 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2496902 Disease Relevance 0.55 Pain Relevance 0.05

General Comments

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