INT158016

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Context Info
Confidence 0.49
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 6.58
Pain Relevance 2.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (VEGFC) signal transduction (VEGFC) extracellular space (VEGFC)
extracellular region (VEGFC)
Anatomy Link Frequency
fibroblast 2
lymph node 1
placenta 1
VEGFC (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 7 99.38 Very High Very High Very High
Inflammation 43 99.20 Very High Very High Very High
COX2 106 98.22 Very High Very High Very High
cva 197 88.80 High High
ischemia 74 86.88 High High
spinal-cord stimulation 38 79.84 Quite High
Clonidine 1 71.60 Quite High
cOX1 6 67.56 Quite High
Angina 44 65.12 Quite High
epidural 6 62.32 Quite High
Disease Link Frequency Relevance Heat
Cancer 75 99.76 Very High Very High Very High
INFLAMMATION 49 99.20 Very High Very High Very High
Atherosclerosis 19 99.08 Very High Very High Very High
Stress 29 99.00 Very High Very High Very High
Eclampsia 5 99.00 Very High Very High Very High
Apoptosis 10 98.26 Very High Very High Very High
Metastasis 8 98.00 Very High Very High Very High
Severe Combined Immunodeficiency 2 97.84 Very High Very High Very High
Conjunctiva Disease 88 97.56 Very High Very High Very High
Rupture 14 96.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tumor lymphangiogenesis was increased in VEGF-C MCF7 tumors injected in nude mice and lymph node metastasis were found more frequently [23].
Positive_regulation (increased) of VEGF-C in lymph node associated with cancer and metastasis
1) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2836381 Disease Relevance 1.02 Pain Relevance 0.08
Soluble Flt-1 binds to circulating free vascular endothelial growth factor and placenta growth factor and this is associated with endothelial dysfunction.
Positive_regulation (circulating) of vascular endothelial growth factor in placenta
2) Confidence 0.27 Published 2009 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 19215236 Disease Relevance 0.34 Pain Relevance 0.07
Moreover, the aforedescribed findings regarding the effects of COX 2 in cutaneous tumor formation have also been reported in pterygium, including disruption of apoptosis [3,18], limbal epithelial proliferation [19], abnormal p53 gene expression [1-5], and upregulation of basic fibroblast growth factor [20], vascular endothelial growth factor, and nitric oxide synthases [21].
Positive_regulation (upregulation) of vascular endothelial growth factor in fibroblast associated with conjunctiva disease, cancer, cox2 and apoptosis
3) Confidence 0.06 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2669508 Disease Relevance 1.06 Pain Relevance 0.41
Also, COX 2 was reported to be a key enzyme for inflammatory cytokine-induced angiogenesis, and the upregulation of vascular endothelial growth factor, basic fibroblast growth factor, and nitric oxide synthases, which are associated with tumor formation [16,17].
Positive_regulation (upregulation) of vascular endothelial growth factor in fibroblast associated with inflammation, cancer, cox2 and cytokine
4) Confidence 0.06 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2669508 Disease Relevance 0.86 Pain Relevance 0.57
Placental growth factor (PIGF), a member of the vascular endothelial growth factor (VEGF) family, was shown to be profoundly upregulated in early and advanced atherosclerotic lesions (Luttun A et al. 2002).
Positive_regulation (upregulated) of vascular endothelial growth factor associated with atherosclerosis
5) Confidence 0.04 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 0.93 Pain Relevance 0.06
A number of genes related to angiogenesis have previously been shown to be upregulated during bone repair, such as vascular endothelial growth factor [26].
Positive_regulation (upregulated) of vascular endothelial growth factor
6) Confidence 0.04 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1578570 Disease Relevance 0.22 Pain Relevance 0
Hyperpolarization, ras activation, nonenzymatic upregulation of NO synthesis, and vascular endothelial growth factor and its tyrosine kinase receptor flt-1 are believed to be mediators of an eventual anti-ischemic effect.
Positive_regulation (upregulation) of vascular endothelial growth factor
7) Confidence 0.03 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941787 Disease Relevance 1.07 Pain Relevance 0.48
Hyperpolarization, ras activation, nonenzymatic upregulation of NO synthesis, and vascular endothelial growth factor and its tyrosine kinase receptor flt-1 are believed to be mediators of an eventual anti-ischemic effect.
Positive_regulation (activation) of vascular endothelial growth factor
8) Confidence 0.03 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941787 Disease Relevance 1.08 Pain Relevance 0.51

General Comments

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