INT158019

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Context Info
Confidence 0.68
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 20
Total Number 21
Disease Relevance 9.73
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (FLT1) endosome (FLT1) Golgi apparatus (FLT1)
cytoplasm (FLT1) extracellular space (FLT1) extracellular region (FLT1)
Anatomy Link Frequency
blood 8
plasma 6
placenta 4
muscle 2
bone marrow 2
FLT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 16 98.78 Very High Very High Very High
Inflammation 54 98.64 Very High Very High Very High
ischemia 25 98.60 Very High Very High Very High
fibrosis 3 85.76 High High
antagonist 33 72.40 Quite High
bradykinin 11 56.64 Quite High
Clonidine 1 54.92 Quite High
palliative 6 38.76 Quite Low
corticosteroid 1 22.68 Low Low
addiction 27 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pre-eclampsia 450 99.84 Very High Very High Very High
Peripheral Arterial Disease 164 99.82 Very High Very High Very High
Eclampsia 35 99.68 Very High Very High Very High
Diabetes Mellitus 51 99.42 Very High Very High Very High
Malignant Neoplastic Disease 8 99.40 Very High Very High Very High
Syndrome 16 98.76 Very High Very High Very High
INFLAMMATION 47 98.64 Very High Very High Very High
Cv Unclassified Under Development 25 98.60 Very High Very High Very High
Adult Respiratory Distress Syndrome 31 98.32 Very High Very High Very High
Hypertension 48 98.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Third, the production of the soluble, alternatively spliced Flt-1, sFlt-1, is significantly higher in preeclamptic patients compared with normotensive pregnant women [28].
Positive_regulation (higher) of Gene_expression (production) of Flt-1
1) Confidence 0.68 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2496902 Disease Relevance 0.16 Pain Relevance 0
Counter to prevailing wisdom, simulated increase in production of sVEGFR1 did not lead to significant reduction in intramuscular VEGF-VEGFR2 complex formation.
Positive_regulation (increase) of Gene_expression (production) of sVEGFR1
2) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0
Third, the production of the soluble, alternatively spliced Flt-1, sFlt-1, is significantly higher in preeclamptic patients compared with normotensive pregnant women [28].
Positive_regulation (higher) of Gene_expression (production) of sFlt-1
3) Confidence 0.49 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2496902 Disease Relevance 0.16 Pain Relevance 0
Recently, it was shown that misregulation of fms-like tyrosine kinase-1 (Flt-1) in the peripheral blood mononuclear cells of pregnant women results in over-expression of the soluble splice variant of Flt-1, sFlt-1, producing an additional (extra-placental) source of sFlt-1 that can contribute to the etiology of preeclampsia.
Positive_regulation (results) of Gene_expression (expression) of Flt-1 in mononuclear cells associated with fibromyalgia and pre-eclampsia
4) Confidence 0.46 Published 2008 Journal BMC Med Genet Section Abstract Doc Link PMC2496902 Disease Relevance 0.70 Pain Relevance 0
Among the four epidermal growth factors, 18 angiogenic genes and six cytokines, only seven genes (namely IL-8, VEGF, bFGF, angiopoietin 1, flt-1, Tie-2 and Tie-1) are overexpressed in WIBC-9 when compared with non-inflammatory models [37].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of flt-1 associated with inflammation and cytokine
5) Confidence 0.44 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 1.26 Pain Relevance 0.20
In diabetic mouse models of PAD, muscle expression of VEGF and sVEGFR1 both increased after surgically-induced hindlimb ischemia [19].
Positive_regulation (increased) of Gene_expression (expression) of sVEGFR1 in muscle associated with diabetes mellitus, ischemia and peripheral arterial disease
6) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0.81 Pain Relevance 0.09
The immediate task is to perform a computational mechanistic study to investigate why simulations of VEGF-trapping by sVEGFR1 did not demonstrate any purported anti-angiogenic effects: Does interstitium-to-blood shuttling of VEGF-sVEGFR1 complexes explain the apparent absence of local reductions in free VEGF upon increased interstitial sVEGFR1 production?
Positive_regulation (interstitial) of Gene_expression (production) of sVEGFR1 in blood
7) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0.09 Pain Relevance 0
A dynamic simulation of the diurnal changes of kL over a combination of “bed-rest days” and “active days”, as illustrated in Fig. 9C, suggested that physiological variation of kL over the course of a day can still account for significant variation in plasma concentrations of VEGF and sVEGFR1.
Positive_regulation (account) of Gene_expression (concentrations) of sVEGFR1 in plasma
8) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0
Also worth considering are the functional consequences of the counter-intuitive increase in plasma VEGF, at the expense of interstitial VEGF, in response to sVEGFR1 production.
Positive_regulation (response) of Gene_expression (production) of sVEGFR1 in plasma
9) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0
The immediate task is to perform a computational mechanistic study to investigate why simulations of VEGF-trapping by sVEGFR1 did not demonstrate any purported anti-angiogenic effects: Does interstitium-to-blood shuttling of VEGF-sVEGFR1 complexes explain the apparent absence of local reductions in free VEGF upon increased interstitial sVEGFR1 production?
Positive_regulation (by) of Gene_expression (production) of sVEGFR1 in blood
10) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0.15 Pain Relevance 0
However, 9 h of sleep was adequate for plasma free sVEGFR1 to fall back to below control levels regardless of whether the subject was active or inactive during waking hours (?
Positive_regulation (for) of Gene_expression (fall) of sVEGFR1 in plasma
11) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0
Distribution changes were again more evident in the blood: the simultaneous elevations in free VEGF and sVEGFR1, due to increasing global kL (e.g., 10× from control), in turn synergistically increased sVEGFR1-VEGF complex formation (e.g., 88× from control), which elevated the complexed fractions of both VEGF (e.g., +13%) and sVEGFR1 (e.g., +8.7%).
Positive_regulation (elevated) of Gene_expression (fractions) of sVEGFR1 in blood
12) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0.09 Pain Relevance 0
The immediate task is to perform a computational mechanistic study to investigate why simulations of VEGF-trapping by sVEGFR1 did not demonstrate any purported anti-angiogenic effects: Does interstitium-to-blood shuttling of VEGF-sVEGFR1 complexes explain the apparent absence of local reductions in free VEGF upon increased interstitial sVEGFR1 production?
Positive_regulation (increased) of Gene_expression (production) of sVEGFR1 in blood
13) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0.09 Pain Relevance 0
In conclusion, placental sFlt-1 and sEng production was higher in pre-eclampsia and antihypertensive drugs had no effect on placental production of sFlt-1 and sEng in vitro.
Positive_regulation (higher) of Gene_expression (production) of sFlt-1 associated with eclampsia
14) Confidence 0.40 Published 2009 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 19215236 Disease Relevance 0.49 Pain Relevance 0.05
It has also been shown that that levels of sFLT-1 are increased in nulliparity (one of the main known risk factors for developing preeclampsia) when compared to multiparous women (Wolf et al. 2005).
Positive_regulation (increased) of Gene_expression (levels) of sFLT-1 associated with pre-eclampsia
15) Confidence 0.35 Published 2008 Journal Trends Cardiovasc Med Section Body Doc Link PMC2577131 Disease Relevance 1.06 Pain Relevance 0
It was suggested that a malignant phenotype is associated with increased VEGFR1 expression.
Positive_regulation (increased) of Gene_expression (expression) of VEGFR1 associated with malignant neoplastic disease
16) Confidence 0.34 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2896958 Disease Relevance 1.11 Pain Relevance 0.03
In mice, transfection of the sFlt-1 gene generates a preeclampsia-like syndrome, with hypertension, proteinuria, and glomerular endotheliosis, even in the absence of pregnancy or a placenta[63].
Positive_regulation (transfection) of Gene_expression (transfection) of sFlt-1 gene in placenta associated with syndrome, proteinuria, hypertension and pre-eclampsia
17) Confidence 0.26 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.56 Pain Relevance 0.03
Finally, serum sFLT-1 levels have been shown to be increased in women with preeclampsia superimposed upon systemic lupus erythematosis (Qazi et al. 2008) and glomerulonephritis (Masuyama et al. 2006).


Positive_regulation (increased) of Gene_expression (levels) of sFLT-1 associated with renal disease, systemic lupus erythematosus and pre-eclampsia
18) Confidence 0.26 Published 2008 Journal Trends Cardiovasc Med Section Body Doc Link PMC2577131 Disease Relevance 1.11 Pain Relevance 0
Given that “delivery” includes both the fetus and the placenta, the group investigated whether fetal as well as maternal levels of sFLT-1 were elevated in preeclampsia.
Spec (whether) Positive_regulation (elevated) of Gene_expression (levels) of sFLT-1 in placenta associated with pre-eclampsia
19) Confidence 0.24 Published 2008 Journal Trends Cardiovasc Med Section Body Doc Link PMC2577131 Disease Relevance 1.10 Pain Relevance 0
Another interesting finding was that AM-hMSCs expressed CD34 and showed increased expression of FLT-1 and KDR when cultured in the presence of VEGF: such expression, which recapitulates the basic phenotypic profile of circulating Endothelial Progenitor Cells (EPCs), is further evidence that AM-hMSCs have an angiogenic potential; the fact that, under the same culture conditions, AM-hMSCs did not express the CD133 surface molecule helps to distinguish these cells from the bone marrow-derived progenitors [41] (data not shown).
Positive_regulation (increased) of Gene_expression (expression) of FLT-1 in bone marrow
20) Confidence 0.19 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1810523 Disease Relevance 0.08 Pain Relevance 0

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