INT15802

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Context Info
Confidence 0.42
First Reported 1991
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 8.16
Pain Relevance 4.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ISG20) nucleoplasm (ISG20) RNA binding (ISG20)
nucleus (ISG20) intracellular (ISG20)
Anatomy Link Frequency
T cells 17
lymphocytes 5
NK cells 2
regulatory T cells 2
ISG20 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 212 100.00 Very High Very High Very High
cINOD 45 99.10 Very High Very High Very High
aspirin 123 97.60 Very High Very High Very High
rheumatoid arthritis 175 96.76 Very High Very High Very High
Inflammation 294 88.00 High High
Opioid 1 86.80 High High
tolerance 26 81.68 Quite High
corticosteroid 5 79.04 Quite High
methotrexate 6 78.32 Quite High
Neuritis 2 78.24 Quite High
Disease Link Frequency Relevance Heat
Mucocutaneous Lymph Node Syndrome 2 100.00 Very High Very High Very High
Endometriosis 90 99.92 Very High Very High Very High
Diabetes Mellitus 12 99.92 Very High Very High Very High
Cicatrix 47 99.84 Very High Very High Very High
Disease 148 99.60 Very High Very High Very High
Aplastic Anemia 1 98.64 Very High Very High Very High
Systemic Lupus Erythematosus 14 97.96 Very High Very High Very High
Autoimmune Disease 71 97.52 Very High Very High Very High
Colitis 6 97.36 Very High Very High Very High
Gastritis 3 97.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased expression of CD25 was also detected in the serum of patients during solid organ allograft rejection, and in those with graft-versus-host disease (GVHD).
Positive_regulation (Increased) of Gene_expression (expression) of CD25 associated with disease and graft vs host disease
1) Confidence 0.42 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004568 Disease Relevance 1.64 Pain Relevance 0.08
BE did not increase the amount of class II MHC antigens on monocytes and did not preferentially stimulate CD69, CD25 and CD71 antigen expression on either CD4+ or CD8+ lymphocytes.
Neg (not) Positive_regulation (stimulate) of Gene_expression (expression) of CD25 in lymphocytes
2) Confidence 0.35 Published 1991 Journal J. Biol. Regul. Homeost. Agents Section Abstract Doc Link 1763657 Disease Relevance 0 Pain Relevance 0.09
CD25 and CD69 antigen expression was higher in scar and ovarian endometriomas than in the control group.


Positive_regulation (higher) of Gene_expression (expression) of CD25 associated with endometriosis and cicatrix
3) Confidence 0.32 Published 2006 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1574328 Disease Relevance 1.39 Pain Relevance 0
The importance of Foxp3 for the regulatory function of Treg cells has been demonstrated by transfection of CD25-CD4+ T cells with a plasmid encoding Foxp3, which conferred a regulatory capacity to the transfected T cells [68].
Positive_regulation (transfection) of Gene_expression (transfection) of CD25 in T cells
4) Confidence 0.19 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.17 Pain Relevance 0.14
A mild increase in CD25 expression was seen on NK cells treated with a 1:100 dilution of MTB.
Positive_regulation (increase) of Gene_expression (expression) of CD25 in NK cells
5) Confidence 0.19 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2858026 Disease Relevance 0.27 Pain Relevance 0.03
To address this, we activated freshly isolated CD4+CD25?
Positive_regulation (isolated) of Gene_expression (isolated) of CD25
6) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.29 Pain Relevance 0.12
Furthermore, co-transfer of CD4+CD25+ T cells with the pathogenic CD4+CD25- T cells prevented the development of experimentally induced autoimmune diseases [55,56].
Positive_regulation (transfer) of Gene_expression (transfer) of CD25 in T cells associated with autoimmune disease
7) Confidence 0.17 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.85 Pain Relevance 0.21
Furthermore, co-transfer of CD4+CD25+ T cells with the pathogenic CD4+CD25- T cells prevented the development of experimentally induced autoimmune diseases [55,56].
Positive_regulation (transfer) of Gene_expression (transfer) of CD25 in T cells associated with autoimmune disease
8) Confidence 0.17 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.85 Pain Relevance 0.21
This suggests a possible role of IL-2 in maintaining viability of CD4+IL-9+T cells generated from resting memory CD4+CD25?
Positive_regulation (generated) of Gene_expression (resting) of CD25 in T cells
9) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0 Pain Relevance 0.11
In defervesce phase of the disease, the number of CD4+CD25high regulatory T cells in patients with Kawasaki disease increases to/or above normal levels, while CD4+CD25high regulatory T cells in patients with infectious febrile disease decrease to normal levels [138].
Positive_regulation (increases) of Gene_expression (regulatory T cells) of CD25high in regulatory T cells associated with mucocutaneous lymph node syndrome, fever and disease
10) Confidence 0.15 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 1.31 Pain Relevance 0.08
This co-incubation with HLA-B27 transfected C1R cells resulted in an increased expression of CD25 on CD4+CD28- T cells in the presence of cross-linking of T cell receptors as compared with co-incubation with nontransfected C1R cells (P = 0.012) and cross-linking of T cell receptors alone (P = 0.012; Fig. 5a).
Positive_regulation (increased) of Gene_expression (expression) of CD25 in T cell
11) Confidence 0.15 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193730 Disease Relevance 0 Pain Relevance 0
NSAIDs were shown to inhibit T cell proliferation, expression of activation-related molecules such as CD25 and CD71, and the production of cytokines such as IL-2, IFN-?
Positive_regulation (activation) of Gene_expression (expression) of CD25 in T cell associated with cinod and cytokine
12) Confidence 0.11 Published 2010 Journal Immune Network Section Body Doc Link PMC2902675 Disease Relevance 0.32 Pain Relevance 0.99
NSAIDs were shown to inhibit T cell proliferation, expression of activation-related molecules such as CD25 and CD71, and the production of cytokines such as IL-2, IFN-?
Positive_regulation (as) of Gene_expression (expression) of CD25 in T cell associated with cinod and cytokine
13) Confidence 0.11 Published 2010 Journal Immune Network Section Body Doc Link PMC2902675 Disease Relevance 0.32 Pain Relevance 1.00
NSAIDs were shown to inhibit T cell proliferation, expression of activation-related molecules such as CD25 and CD71, and the production of cytokines such as IL-2, IFN-?
Positive_regulation (as) of Gene_expression (expression) of CD25 in T cell associated with cinod and cytokine
14) Confidence 0.11 Published 2010 Journal Immune Network Section Body Doc Link PMC2902675 Disease Relevance 0.32 Pain Relevance 0.99
In addition, an increase in peripheral lymphocytes, T cells and Th cells, enhanced expression of CD25+ and HLA-DQ+ activation markers, and increased concentration of acute phase proteins and of complement factor C3 could be observed (60–63).
Positive_regulation (enhanced) of Gene_expression (expression) of CD25 in lymphocytes
15) Confidence 0.09 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1062151 Disease Relevance 0.21 Pain Relevance 0
In addition, an increase in peripheral lymphocytes, T cells and Th cells, enhanced expression of CD25+ and HLA-DQ+ activation markers, and increased concentration of acute phase proteins and of complement factor C3 could be observed (60–63).
Positive_regulation (enhanced) of in T cells Gene_expression (expression) of CD25 in lymphocytes
16) Confidence 0.03 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1062151 Disease Relevance 0.21 Pain Relevance 0

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