INT158022

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 14.18
Pain Relevance 1.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CHI3L1) extracellular region (CHI3L1) endoplasmic reticulum (CHI3L1)
proteinaceous extracellular matrix (CHI3L1) carbohydrate metabolic process (CHI3L1) cytoplasm (CHI3L1)
Anatomy Link Frequency
plasma 6
cartilage 1
synovium 1
CHI3L1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 12 99.76 Very High Very High Very High
Inflammatory marker 9 95.24 Very High Very High Very High
tolerance 63 92.76 High High
Inflammation 157 91.04 High High
Pain 2 85.44 High High
Inflammatory response 2 74.88 Quite High
cytokine 21 66.72 Quite High
beta blocker 9 5.00 Very Low Very Low Very Low
cINOD 7 5.00 Very Low Very Low Very Low
Angina 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 12 99.76 Very High Very High Very High
Coronary Artery Disease 228 99.30 Very High Very High Very High
Obesity 381 99.20 Very High Very High Very High
Myocardial Infarction 30 98.20 Very High Very High Very High
Disease 32 95.76 Very High Very High Very High
INFLAMMATION 172 94.92 High High
Diabetes Mellitus 367 93.76 High High
Impaired Glucose Tolerance 63 92.76 High High
Disease Progression 2 89.92 High High
Calcification 279 85.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
or fasting plasma glucose since these parameters were highly associated with YKL-40 in the univariate analysis.
YKL-40 Binding (associated) of in plasma
1) Confidence 0.43 Published 2008 Journal Diabetes Section Body Doc Link PMC2570404 Disease Relevance 1.21 Pain Relevance 0.17
The presence of YKL-40 in cartilage and synovium in OA patients correlates with histopathological changes and may reflect local disease activity.
YKL-40 Binding (presence) of in synovium associated with disease and osteoarthritis
2) Confidence 0.36 Published 2009 Journal J. Int. Med. Res. Section Abstract Doc Link 19215669 Disease Relevance 0.96 Pain Relevance 0.45
There was a tendency to a positive association between YKL-40 mRNA and A1C (P = 0.0645).
YKL-40 mRNA Binding (association) of
3) Confidence 0.32 Published 2008 Journal Diabetes Section Body Doc Link PMC2570404 Disease Relevance 0.85 Pain Relevance 0.08
Age and fitness level showed separate associations with plasma YKL-40 (?
plasma YKL-40 Binding (associations) of in plasma
4) Confidence 0.29 Published 2008 Journal Diabetes Section Body Doc Link PMC2570404 Disease Relevance 0.69 Pain Relevance 0.13
There was a tendency toward a positive association between plasma YKL-40 and HOMA2 (P = 0.0545).
plasma YKL-40 Binding (association) of in plasma
5) Confidence 0.29 Published 2008 Journal Diabetes Section Body Doc Link PMC2570404 Disease Relevance 0.79 Pain Relevance 0.13
Multivariate regression analysis showed that plasma YKL-40 was associated with fasting plasma glucose (?
plasma YKL-40 Binding (associated) of in plasma
6) Confidence 0.28 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2570404 Disease Relevance 1.40 Pain Relevance 0.15
or fasting plasma glucose, we found significant associations between plasma YKL-40 and fasting plasma glucose and plasma IL-6 but no associations with parameters of obesity.
plasma YKL-40 Neg (no) Binding (associations) of in plasma associated with obesity
7) Confidence 0.28 Published 2008 Journal Diabetes Section Body Doc Link PMC2570404 Disease Relevance 0.82 Pain Relevance 0.04
or fasting plasma glucose, we found significant associations between plasma YKL-40 and fasting plasma glucose and plasma IL-6 but no associations with parameters of obesity.
plasma YKL-40 Neg (no) Binding (associations) of in plasma associated with obesity
8) Confidence 0.28 Published 2008 Journal Diabetes Section Body Doc Link PMC2570404 Disease Relevance 0.84 Pain Relevance 0.04
The presence of YKL-40 in cartilage and synovium in OA patients correlates with histopathological changes and may reflect local disease activity.
YKL-40 Binding (presence) of in cartilage associated with disease and osteoarthritis
9) Confidence 0.12 Published 2009 Journal J. Int. Med. Res. Section Abstract Doc Link 19215669 Disease Relevance 0.96 Pain Relevance 0.45
Statin treatment in especially IHD patients could also influence the levels of both YKL-40 and hsCRP, but without this treatment we would expect even higher levels of both markers in the IHD groups.
YKL-40 Binding (levels) of associated with coronary artery disease
10) Confidence 0.06 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3016330 Disease Relevance 2.29 Pain Relevance 0.21
YKL-40 has also been found to be associated with all-cause as well as cardiovascular mortality in both patients with stable IHD [31] and in the general population above 50 years of age without known diabetes or IHD [28].
YKL-40 Binding (associated) of associated with coronary artery disease and diabetes mellitus
11) Confidence 0.06 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3016330 Disease Relevance 1.75 Pain Relevance 0.03
Studies have shown, that increased levels of YKL-40 are independently associated with the presence and extent of CAD [29-32].
YKL-40 Binding (associated) of associated with coronary artery disease
12) Confidence 0.06 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3016330 Disease Relevance 1.61 Pain Relevance 0.06

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