INT15803

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Context Info
Confidence 0.44
First Reported 1987
Last Reported 2010
Negated 4
Speculated 1
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 12.57
Pain Relevance 5.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IFNG) extracellular region (IFNG)
Anatomy Link Frequency
T-cell 4
macrophage 2
CSF 1
neuronal 1
immune cells 1
IFNG (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 123 100.00 Very High Very High Very High
Inflammation 35 100.00 Very High Very High Very High
abatacept 9 100.00 Very High Very High Very High
Morphine 9 98.80 Very High Very High Very High
antidepressant 10 98.52 Very High Very High Very High
psoriasis 1 95.72 Very High Very High Very High
Abeta 7 95.60 Very High Very High Very High
monoamine 4 95.36 Very High Very High Very High
rheumatoid arthritis 2 95.28 Very High Very High Very High
Multiple sclerosis 3 94.40 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 44 100.00 Very High Very High Very High
Autoimmune Disease 12 99.92 Very High Very High Very High
Mycobacterial Infection 35 99.72 Very High Very High Very High
Cancer 46 99.64 Very High Very High Very High
Respiratory Syncytial Virus 57 99.52 Very High Very High Very High
Apoptosis 7 99.44 Very High Very High Very High
Necrosis 4 99.40 Very High Very High Very High
Adhesions 39 99.38 Very High Very High Very High
Chronic Hepatitis 2 98.96 Very High Very High Very High
Diabetes Mellitus 100 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A randomised controlled trial of recombinant interferon-gamma in Chinese patients with chronic hepatitis B virus infection.
Regulation (controlled) of interferon-gamma associated with chronic hepatitis and infection
1) Confidence 0.44 Published 1991 Journal J. Med. Virol. Section Title Doc Link 1919540 Disease Relevance 1.04 Pain Relevance 0.06
BE did not consistently influence the amount of IL-1, IL-2 and IFN-gamma found in the supernatant of ConA stimulated cultures.
Neg (not) Regulation (influence) of IFN-gamma
2) Confidence 0.33 Published 1991 Journal J. Biol. Regul. Homeost. Agents Section Abstract Doc Link 1763657 Disease Relevance 0 Pain Relevance 0.09
In the brain activation pattern elicited by the predefined theatrical events designed by the stage director to prompt the adhesion of the spectators, the signal changes in two regions, in the left ventral IFG (BA 47) and pSTS positively correlated with the degree of adhesion of the spectators, induced by these events.
Regulation (changes) of IFG in ventral associated with adhesions
3) Confidence 0.31 Published 2010 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC2936906 Disease Relevance 0.48 Pain Relevance 0
Overall, our results indicate that IFN-gamma producing T-cells (Th(1) cells) are the major target for the immunomodulatory actions of antidepressants, and provide evidence questioning the relationship between the monoaminergic reuptake properties of antidepressants and their immunomodulatory effects.
Regulation (target) of IFN-gamma in T-cells associated with antidepressant and monoamine
4) Confidence 0.26 Published 2006 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 16388933 Disease Relevance 0.05 Pain Relevance 0.90
In spite of the reduced size of the population studied, the results suggest the efficacy of IFN gamma on DR-TB, when used as adjuvant to chemotherapy.
Regulation (efficacy) of IFN gamma associated with mycobacterial infection
5) Confidence 0.26 Published 2004 Journal BMC Infect Dis Section Body Doc Link PMC529257 Disease Relevance 0.56 Pain Relevance 0
Inflammation of the skin overlying the TMJ had no effect on IFI.
Neg (no) Regulation (effect) of IFI in skin
6) Confidence 0.23 Published 2007 Journal J Orofac Pain Section Body Doc Link 17312637 Disease Relevance 0.12 Pain Relevance 0
It is possible to detect changes in IFI as small as 40% with 12 rats per group.


Regulation (changes) of IFI
7) Confidence 0.23 Published 2007 Journal J Orofac Pain Section Body Doc Link 17312637 Disease Relevance 0 Pain Relevance 0
In contrast, ASA did not affect IL-13, interferon-gamma, and IL-2 expression.
Neg (not) Regulation (affect) of interferon-gamma
8) Confidence 0.15 Published 2001 Journal Blood Section Abstract Doc Link 11238116 Disease Relevance 0.08 Pain Relevance 0.29
Normal concentrations of IL-1beta, IL-6, IFN-gamma and TNF-alpha were present in CSF and serum in almost all patients with lumbar disc herniation.
Regulation (concentrations) of IFN-gamma in CSF
9) Confidence 0.15 Published 2002 Journal Eur Spine J Section Abstract Doc Link 11931066 Disease Relevance 0.66 Pain Relevance 0.65
We found that morphine significantly promoted IL-4 and IL-13 production but did not alter IL-5 or IFN-gamma.
Neg (not) Regulation (alter) of IFN-gamma associated with morphine
10) Confidence 0.11 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16210602 Disease Relevance 0.68 Pain Relevance 0.87
Two patients had interferon-gamma predominant responses and 3 had IL-5 predominant responses.
Regulation (responses) of interferon-gamma
11) Confidence 0.07 Published 2007 Journal J. Immunother. Section Abstract Doc Link 17471169 Disease Relevance 1.00 Pain Relevance 0.14
IFN-gamma response was low in RSV affected children as expected [27,28].
Regulation (response) of IFN-gamma associated with respiratory syncytial virus
12) Confidence 0.07 Published 2009 Journal Respir Res Section Body Doc Link PMC2762974 Disease Relevance 1.35 Pain Relevance 0.18
In the present study, the neuronal cell line Sk-n-sh was incubated for 12 h with the cyclooxygenase inhibitor ibuprofen and subsequently stimulated with the cytokines TNFalpha and IFNgamma.
Regulation (stimulated) of IFNgamma in neuronal associated with cytokine
13) Confidence 0.06 Published 2001 Journal Neurobiol. Dis. Section Abstract Doc Link 11741404 Disease Relevance 0.77 Pain Relevance 0.75
Curcumin inhibits these autoimmune diseases by regulating inflammatory cytokines such as IL-1beta, IL-6, IL-12, TNF-alpha and IFN-gamma and associated JAK-STAT, AP-1, and NF-kappaB signaling pathways in immune cells.
Regulation (regulating) of IFN-gamma in immune cells associated with autoimmune disease, inflammation and cytokine
14) Confidence 0.06 Published 2007 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 17569223 Disease Relevance 1.88 Pain Relevance 0.48
So, the first response of the host immune system consists of classically activated macrophages (caM?)
Regulation (response) of immune in immune system
15) Confidence 0.05 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2826769 Disease Relevance 0.77 Pain Relevance 0.27
We measured interleukin-1beta, interleukin-6, interferon-gamma inducible protein-10, RANTES (regulated upon activation, normal T-cell expressed and secreted), complement C3, mannose-binding lectin, complement C1q, soluble intercellular adhesion molecule-1, endothelin-1, nitric oxide, human lactoferrin, and hypocretin-1 levels in these samples.
Regulation (regulated) of interferon-gamma in T-cell
16) Confidence 0.03 Published 2008 Journal Clin J Pain Section Body Doc Link 18180633 Disease Relevance 0.18 Pain Relevance 0
Couto et al[11] have recognized Janus kinase1-Signal transducer and activator of transcription1 (JAK1-STAT1) pathway as novel target of EX-4, where the drug produces downregulation of JAK1-STAT1 transduction mechanism which is an important signaling route mediating the interferon-gamma effects on beta-cell apoptosis in T1DM.
Regulation (effects) of interferon-gamma associated with diabetes mellitus and apoptosis
17) Confidence 0.03 Published 2010 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2883206 Disease Relevance 0.43 Pain Relevance 0.12
All the above factors affect IFG-1 levels.
Regulation (affect) of IFG-1
18) Confidence 0.01 Published 2007 Journal BMC Endocr Disord Section Body Doc Link PMC2151943 Disease Relevance 1.13 Pain Relevance 0.06
Interleukin 1 and interferon-gamma: cytokines that provide reciprocal regulation of macrophage and T cell function.
Regulation (regulation) of interferon-gamma in T cell associated with cytokine
19) Confidence 0.01 Published 1987 Journal Toxicol Pathol Section Title Doc Link 3120294 Disease Relevance 0.24 Pain Relevance 0.05
In addition to the effect of abatacept on proliferation, T-cell cytokines, IL-2, TNFalpha and IFNgamma were also reduced.
Regulation (effect) of IFNgamma in T-cell associated with abatacept and cytokine
20) Confidence 0.01 Published 2008 Journal Clin. Immunol. Section Abstract Doc Link 17945538 Disease Relevance 0.08 Pain Relevance 0.92

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