INT15804

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Context Info
Confidence 0.75
First Reported 1991
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 83
Total Number 89
Disease Relevance 44.33
Pain Relevance 10.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ISG20) nucleoplasm (ISG20) RNA binding (ISG20)
nucleus (ISG20) intracellular (ISG20)
Anatomy Link Frequency
T cells 26
regulatory T cells 10
lymphocytes 3
cytotoxic T lymphocyte 2
monocytes 2
ISG20 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 432 99.84 Very High Very High Very High
cINOD 27 99.10 Very High Very High Very High
endometriosis 417 98.88 Very High Very High Very High
cytokine 788 98.68 Very High Very High Very High
intrathecal 2 97.50 Very High Very High Very High
COX-2 inhibitor 3 97.20 Very High Very High Very High
Inflammation 969 96.28 Very High Very High Very High
Arthritis 382 95.32 Very High Very High Very High
aspirin 41 93.60 High High
spastic colon 95 93.08 High High
Disease Link Frequency Relevance Heat
Infection 176 100.00 Very High Very High Very High
Epstein-barr Virus 92 100.00 Very High Very High Very High
Endometriosis 720 99.92 Very High Very High Very High
Rheumatoid Arthritis 492 99.84 Very High Very High Very High
Disease 882 99.60 Very High Very High Very High
Diabetes Mellitus 77 99.52 Very High Very High Very High
Cicatrix 376 99.40 Very High Very High Very High
Mucocutaneous Lymph Node Syndrome 28 99.28 Very High Very High Very High
Fatigue 21 99.24 Very High Very High Very High
Lymphatic System Cancer 242 99.10 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When light chain restriction was observed, anti-CD38, FMC-7, CD79b, CD22, CD103, CD11c, CD25 expression were also investigated on B-cells to better characterize B-cell phenotype [6] and to investigate the concordance between the diagnosis reported and the phenotype of the pathological B-lymphocytes observed.
Spec (investigated) Gene_expression (expression) of CD25 in B-cells
1) Confidence 0.75 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2995803 Disease Relevance 0.66 Pain Relevance 0
They constitutively expressed CD69 and CD25 as well as molecules associated with CD4+ CD25+ regulatory T cells, including cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) and Foxp3.
Gene_expression (expressed) of CD25 in cytotoxic T lymphocyte
2) Confidence 0.62 Published 2005 Journal Eur. J. Immunol. Section Abstract Doc Link 16180249 Disease Relevance 0.14 Pain Relevance 0.10
We evaluated the effect of timing of BE addition to the culture medium on thymidine uptake, the kinetics of expression of activation markers (CD69, CD25 and CD71) on CD4+ and CD8+ lymphocytes, and of class II MHC antigens on CD14+ cells (monocytes), the kinetics of interleukin-1 (IL-1), interleukin-2 (IL-2) and interferon gamma (IFN-gamma) release, and the cell cycle.
Gene_expression (expression) of CD25 in monocytes
3) Confidence 0.59 Published 1991 Journal J. Biol. Regul. Homeost. Agents Section Abstract Doc Link 1763657 Disease Relevance 0 Pain Relevance 0
Treatment resulted in a decrease in the concentration of myelin basic protein, a decrease in the serum concentration of immunoglobulin G (IgG) and intrathecal IgG synthesis, an increase in the cerebrospinal fluid concentration of transforming growth factor-beta1, and changes in the expression of CD25, CD26, and human leukocyte antigen-DR (HLA-DR) on CD4 T-cells.
Gene_expression (expression) of CD25 in T-cells associated with intrathecal
4) Confidence 0.55 Published 2000 Journal Eur. J. Neurol. Section Abstract Doc Link 10886311 Disease Relevance 0.62 Pain Relevance 0.60
Statistically significantly lower CD25 expression was detected in ovarian than in scar endometriosis (p = 0.005).
Gene_expression (expression) of CD25 associated with endometriosis and cicatrix
5) Confidence 0.53 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.88 Pain Relevance 0.50
CD25 antigen expression was statistically significantly higher in scar endometriosis than in the control group (p = 0.02).
Gene_expression (expression) of CD25 associated with endometriosis and cicatrix
6) Confidence 0.53 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.87 Pain Relevance 0.55
No differences in CD25 expression were identified between ovarian endometriosis and the control group.
Gene_expression (expression) of CD25 associated with endometriosis
7) Confidence 0.53 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.84 Pain Relevance 0.52
Interestingly, treatment with COX-2-specific inhibitors such as NS398 or Celecoxib severely diminished early and late events of T cell activation, including CD25 and CD71 cell surface expression, IL-2, TNF-alpha, and IFN-gamma production and cell proliferation, but not the expression of CD69, an immediate early gene.
Gene_expression (expression) of CD25 in T cell
8) Confidence 0.48 Published 1999 Journal J. Immunol. Section Abstract Doc Link 10384106 Disease Relevance 0.15 Pain Relevance 0.22
In an unpublished meta-analysis of three phase III clinical trials of denileukin diftitox for the treatment of CTCL, Negro-Vilar also reported there was no correlation between CD25 expression and response.33

Denileukin diftitox in combination treatments

Gene_expression (expression) of CD25 associated with lymphatic system cancer
9) Confidence 0.47 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004568 Disease Relevance 0.54 Pain Relevance 0
CD25 expression on CD4+ cells was measured by immunohistochemistry or flow cytometry at baseline and after 7 days of bexarotene.
Gene_expression (expression) of CD25
10) Confidence 0.47 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004568 Disease Relevance 0.57 Pain Relevance 0
However, the greatest level of expression of CD25 is seen in the setting of T-cell malignancies such as cutaneous T-cell lymphoma, and adult T-cell leukemia.
Gene_expression (expression) of CD25 in T-cell associated with leukemia and lymphatic system cancer
11) Confidence 0.47 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004568 Disease Relevance 0.55 Pain Relevance 0.04
Increased expression of CD25 was also detected in the serum of patients during solid organ allograft rejection, and in those with graft-versus-host disease (GVHD).
Gene_expression (expression) of CD25 associated with disease and graft vs host disease
12) Confidence 0.47 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004568 Disease Relevance 1.58 Pain Relevance 0.08
BE did not increase the amount of class II MHC antigens on monocytes and did not preferentially stimulate CD69, CD25 and CD71 antigen expression on either CD4+ or CD8+ lymphocytes.
Gene_expression (expression) of CD25 in lymphocytes
13) Confidence 0.46 Published 1991 Journal J. Biol. Regul. Homeost. Agents Section Abstract Doc Link 1763657 Disease Relevance 0 Pain Relevance 0.09
INF and farnesol did not suppress the expression of early activation markers, including CD98, CD25, and CD71, on SA-stimulated B cells, but appeared to inhibit the maturation of B cells following the initial activation.
Gene_expression (expression) of CD25 in B cells
14) Confidence 0.43 Published 1999 Journal Immunopharmacology Section Abstract Doc Link 10598881 Disease Relevance 0.27 Pain Relevance 0.18
0.872, P<0.001), and 74.03% (52.09–89.75) of CD25+CD127?
Gene_expression (0.872) of CD25
15) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001453 Disease Relevance 0.14 Pain Relevance 0
Interestingly, treatment with COX-2-specific inhibitors such as NS398 or Celecoxib severely diminished early and late events of T cell activation, including CD25 and CD71 cell surface expression, IL-2, TNF-alpha, and IFN-gamma production and cell proliferation, but not the expression of CD69, an immediate early gene.
Gene_expression (expression) of CD25 in T cell
16) Confidence 0.41 Published 1999 Journal J. Immunol. Section Abstract Doc Link 10384106 Disease Relevance 0.15 Pain Relevance 0.22
Interestingly, treatment with COX-2-specific inhibitors such as NS398 or Celecoxib severely diminished early and late events of T cell activation, including CD25 and CD71 cell surface expression, IL-2, TNF-alpha, and IFN-gamma production and cell proliferation, but not the expression of CD69, an immediate early gene.
Gene_expression (expression) of CD25 in T cell
17) Confidence 0.41 Published 1999 Journal J. Immunol. Section Abstract Doc Link 10384106 Disease Relevance 0.15 Pain Relevance 0.23
Five-micrometer sections from each case were stained to visualize expression of RCAS1, MT and CD16-, CD25-, CD69-, CD56-positive cells (mainly lymphocytes) as well as CD68+ cells, or macrophages.
Gene_expression (expression) of CD25 in macrophages
18) Confidence 0.41 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 0.41 Pain Relevance 0.06
A decrease of CD25 antigen expression with a concomitant increase of CD69 expression has been observed in the endometrium according to the menstrual cycle changes [21].
Gene_expression (expression) of CD25 in endometrium
19) Confidence 0.41 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.21 Pain Relevance 0.27
Metallothionein, RCAS1, CD25, CD69, CD56, CD16, CD68 antigen expression was assessed by immunohistochemistry in ovarian and scar endometriomas tissue samples which were obtained from 33 patients.
Gene_expression (expression) of CD25 associated with endometriosis and cicatrix
20) Confidence 0.41 Published 2006 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1574328 Disease Relevance 1.10 Pain Relevance 0

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