INT158048

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Context Info
Confidence 0.28
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.79
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPKAPK2) nucleoplasm (MAPKAPK2) small molecule metabolic process (MAPKAPK2)
nucleus (MAPKAPK2) response to stress (MAPKAPK2) cytoplasm (MAPKAPK2)
Anatomy Link Frequency
B-cell 1
MAPKAPK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1 97.20 Very High Very High Very High
psoriasis 1 90.52 High High
rheumatoid arthritis 1 89.96 High High
cINOD 1 75.00 Quite High
agonist 1 74.40 Quite High
gABA 1 74.08 Quite High
Spinal cord 6 5.00 Very Low Very Low Very Low
Somatosensory cortex 2 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 2 97.20 Very High Very High Very High
Disease 1 96.68 Very High Very High Very High
Multiple Myeloma 1 93.88 High High
Malignant Neoplastic Disease 1 92.36 High High
Psoriasis 1 90.52 High High
Rheumatoid Arthritis 1 89.96 High High
Chronic Disease 1 81.64 Quite High
Cancer 1 76.48 Quite High
Amputation 2 5.00 Very Low Very Low Very Low
Paralysis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In Mk2, only one muscimol inactivation session was conducted on the ipsilesional hemisphere five months post-lesion, in which a total volume of 12 ?
Gene_expression (conducted) of Mk2
1) Confidence 0.28 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1224856 Disease Relevance 0 Pain Relevance 0.07
Here I briefly review the potential problems in targeting p38 MAPK and discuss other protein kinases that regulate the innate immune system, such as Tpl2, MAPKAP-K2/3, MSK1/2 and IRAK4, which may be better targets for the treatment of chronic inflammatory diseases, and NIK, which is an attractive target for the treatment of multiple myeloma, a late stage B-cell malignancy.
Gene_expression (/) of MAPKAP-K2 in B-cell associated with malignant neoplastic disease, inflammation, multiple myeloma and disease
2) Confidence 0.00 Published 2009 Journal Curr. Opin. Cell Biol. Section Abstract Doc Link 19217767 Disease Relevance 0.79 Pain Relevance 0.21

General Comments

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