INT15805

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Context Info
Confidence 0.75
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 35
Total Number 36
Disease Relevance 17.44
Pain Relevance 8.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (TFRC) peptidase activity (TFRC) mitochondrion (TFRC)
aging (TFRC) extracellular region (TFRC) cytoplasmic membrane-bounded vesicle (TFRC)
Anatomy Link Frequency
T cell 5
monocytes 3
mesencephalon 2
lymphocytes 2
NK cell 2
TFRC (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 180 99.08 Very High Very High Very High
cytokine 84 98.72 Very High Very High Very High
Central grey 25 98.28 Very High Very High Very High
qutenza 66 97.64 Very High Very High Very High
Morphine 34 97.58 Very High Very High Very High
COX-2 inhibitor 3 97.20 Very High Very High Very High
Spinal cord 6 95.32 Very High Very High Very High
primary somatosensory cortex 34 94.88 High High
Cluster headache 4 94.80 High High
Versed 5 93.44 High High
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 95 99.68 Very High Very High Very High
Pancreatitis 6 99.52 Very High Very High Very High
INFLAMMATION 205 99.08 Very High Very High Very High
Pulmonary Alveolar Proteinosis 621 98.72 Very High Very High Very High
Nicotine Addiction 229 98.64 Very High Very High Very High
Urological Neuroanatomy 32 98.28 Very High Very High Very High
Stress 406 97.92 Very High Very High Very High
Nociception 9 96.96 Very High Very High Very High
Cluster Headache 4 94.80 High High
Ataxia 24 93.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, treatment with COX-2-specific inhibitors such as NS398 or Celecoxib severely diminished early and late events of T cell activation, including CD25 and CD71 cell surface expression, IL-2, TNF-alpha, and IFN-gamma production and cell proliferation, but not the expression of CD69, an immediate early gene.
Gene_expression (expression) of CD71 in T cell
1) Confidence 0.75 Published 1999 Journal J. Immunol. Section Abstract Doc Link 10384106 Disease Relevance 0.15 Pain Relevance 0.22
Interestingly, treatment with COX-2-specific inhibitors such as NS398 or Celecoxib severely diminished early and late events of T cell activation, including CD25 and CD71 cell surface expression, IL-2, TNF-alpha, and IFN-gamma production and cell proliferation, but not the expression of CD69, an immediate early gene.
Gene_expression (expression) of CD71 in T cell
2) Confidence 0.65 Published 1999 Journal J. Immunol. Section Abstract Doc Link 10384106 Disease Relevance 0.15 Pain Relevance 0.22
Interestingly, treatment with COX-2-specific inhibitors such as NS398 or Celecoxib severely diminished early and late events of T cell activation, including CD25 and CD71 cell surface expression, IL-2, TNF-alpha, and IFN-gamma production and cell proliferation, but not the expression of CD69, an immediate early gene.
Gene_expression (expression) of CD71 in T cell
3) Confidence 0.65 Published 1999 Journal J. Immunol. Section Abstract Doc Link 10384106 Disease Relevance 0.15 Pain Relevance 0.23
In addition, we studied the expression of Leu-4, specific for T-cells; of Leu-11b, specific for FC receptor on NK cells; and the Transferrin Receptor, specific for lymphoblasts and monocytes.
Gene_expression (expression) of Transferrin Receptor in NK cells
4) Confidence 0.61 Published 1990 Journal Headache Section Abstract Doc Link 2335478 Disease Relevance 0.32 Pain Relevance 0.32
Also, no significant difference was found in monocyte numbers or their human leukocyte antigen-DR, CD86, or CD71 expression.
Gene_expression (expression) of CD71 in leukocyte
5) Confidence 0.52 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15041604 Disease Relevance 0.58 Pain Relevance 0.87
BE did not increase the amount of class II MHC antigens on monocytes and did not preferentially stimulate CD69, CD25 and CD71 antigen expression on either CD4+ or CD8+ lymphocytes.
Gene_expression (expression) of CD71 in lymphocytes
6) Confidence 0.50 Published 1991 Journal J. Biol. Regul. Homeost. Agents Section Abstract Doc Link 1763657 Disease Relevance 0 Pain Relevance 0.09
We evaluated the effect of timing of BE addition to the culture medium on thymidine uptake, the kinetics of expression of activation markers (CD69, CD25 and CD71) on CD4+ and CD8+ lymphocytes, and of class II MHC antigens on CD14+ cells (monocytes), the kinetics of interleukin-1 (IL-1), interleukin-2 (IL-2) and interferon gamma (IFN-gamma) release, and the cell cycle.
Gene_expression (expression) of CD71 in monocytes
7) Confidence 0.50 Published 1991 Journal J. Biol. Regul. Homeost. Agents Section Abstract Doc Link 1763657 Disease Relevance 0 Pain Relevance 0
A very similar oscillatory response appeared also in the total TFR, which we label TR I (total response I, t(15) = ?
Gene_expression (appeared) of TFR
8) Confidence 0.41 Published 2009 Journal Journal of pain research Section Body Doc Link PMC3004625 Disease Relevance 0.05 Pain Relevance 0.24
A very similar oscillatory response appeared also in the total TFR, which we label TR I (total response I, t(15) = ?
Gene_expression (label) of TFR
9) Confidence 0.41 Published 2009 Journal Journal of pain research Section Body Doc Link PMC3004625 Disease Relevance 0.05 Pain Relevance 0.24
Circulating cytokines, C-reactive protein (CRP), cortisol, and cell-surface receptor expression of immune cells (cluster of differentiation [CD]14, human leukocyte antigen-DR, CD86, CD71, CD3, CD4, CD8, CD16, and CD19) were measured perioperatively to characterize immunological functions.
Gene_expression (expression) of CD71 in CD86 associated with cytokine
10) Confidence 0.40 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15041604 Disease Relevance 0.48 Pain Relevance 0.67
We measured lavage concentrations of iron, as well as levels of transferrin, transferrin receptor, lactoferrin, and ferritin as indices of the metal's homeostasis.
Gene_expression (levels) of transferrin receptor
11) Confidence 0.37 Published 2008 Journal Respir Res Section Body Doc Link PMC2265287 Disease Relevance 0.23 Pain Relevance 0.06
Alterations in iron metabolism were evidenced by elevations in both concentrations of iron and levels of transferrin, transferrin receptor, lactoferrin, and ferritin in all patients with PAP.
Gene_expression (levels) of transferrin receptor associated with pulmonary alveolar proteinosis
12) Confidence 0.37 Published 2008 Journal Respir Res Section Body Doc Link PMC2265287 Disease Relevance 1.03 Pain Relevance 0
The TFR analysis of the ADHD group showed a strong early ERS in the lower bandwidths (theta and low alpha) and high beta band (25 to 40 Hz), but little power in the midrange (10 to 22 Hz) followed by ERD and a rebound ERS composed of strong activation during the first half of the rebound period and reduced activation in the latter half (Figure 3B).
Gene_expression (analysis) of TFR in band associated with somatosensory cortex and attention deficit hyperactivity disorder
13) Confidence 0.35 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2266931 Disease Relevance 0.30 Pain Relevance 0.32
INF and farnesol did not suppress the expression of early activation markers, including CD98, CD25, and CD71, on SA-stimulated B cells, but appeared to inhibit the maturation of B cells following the initial activation.
Gene_expression (expression) of CD71 in B cells
14) Confidence 0.32 Published 1999 Journal Immunopharmacology Section Abstract Doc Link 10598881 Disease Relevance 0.27 Pain Relevance 0.18
TfR and ferritin were measured with commercial ELISA kits (R & D Systems, Minneapolis, MN) as were lactoferrin concentrations (Calbiochem, La Jolla, CA).
Gene_expression (measured) of TfR
15) Confidence 0.32 Published 2008 Journal Respir Res Section Body Doc Link PMC2265287 Disease Relevance 0.17 Pain Relevance 0
The transferrin receptor is also often found in measurable quantities in BAL fluid [21].
Gene_expression (found) of transferrin receptor
16) Confidence 0.32 Published 2008 Journal Respir Res Section Body Doc Link PMC2265287 Disease Relevance 0.77 Pain Relevance 0
UTR and increase the rate of synthesis of iron uptake proteins such as TfR1.
Gene_expression (synthesis) of TfR1
17) Confidence 0.30 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.79 Pain Relevance 0
Healthy volunteers (n = 20) and patients with idiopathic PAP (n = 20) underwent bronchoalveolar lavage and measurements were made of total protein, iron, tranferrin, transferrin receptor, lactoferrin, and ferritin.
Gene_expression (made) of transferrin receptor associated with pulmonary alveolar proteinosis
18) Confidence 0.29 Published 2008 Journal Respir Res Section Abstract Doc Link PMC2265287 Disease Relevance 1.22 Pain Relevance 0
With exposure to iron, many cell types rapidly down regulate TfR expression to limit iron uptake.
Gene_expression (expression) of TfR
19) Confidence 0.29 Published 2008 Journal Respir Res Section Body Doc Link PMC2265287 Disease Relevance 1.03 Pain Relevance 0.13
Similarly, soluble transferrin receptor levels in the lavage of patients with PAP were also approximately ten-fold higher than in normal subjects (Figure 2B).
Gene_expression (levels) of transferrin receptor associated with pulmonary alveolar proteinosis
20) Confidence 0.29 Published 2008 Journal Respir Res Section Body Doc Link PMC2265287 Disease Relevance 0.66 Pain Relevance 0.03

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