INT158056

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Context Info
Confidence 0.79
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 13
Total Number 25
Disease Relevance 3.11
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Nrg1) extracellular space (Nrg1) cell morphogenesis (Nrg1)
plasma membrane (Nrg1) cytoplasm (Nrg1)
Anatomy Link Frequency
radial 6
cleavage 4
neuron 1
Schwann cell 1
Nrg1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 9 99.12 Very High Very High Very High
Neurotransmitter 34 96.76 Very High Very High Very High
Glutamate 139 91.32 High High
conotoxin 1 84.32 Quite High
anesthesia 15 83.88 Quite High
analgesia 1 83.40 Quite High
Spinal cord 7 82.32 Quite High
tolerance 1 79.08 Quite High
Nicotine 84 78.20 Quite High
Analgesic 1 77.80 Quite High
Disease Link Frequency Relevance Heat
Stress 62 99.98 Very High Very High Very High
Disease 29 98.68 Very High Very High Very High
Disseminated Intravascular Coagulation 130 96.40 Very High Very High Very High
Death 31 95.64 Very High Very High Very High
Lifespan 13 95.52 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 12 91.88 High High
Targeted Disruption 115 84.32 Quite High
Shock 16 77.48 Quite High
Demyelinating Disease 17 76.96 Quite High
Diabetes Mellitus 40 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although Types I and II Nrg1 are either directly secreted or released after constitutive cleavage, Type III Nrg1 remains membrane tethered as a result of its unique N-terminal transmembrane domain (Wang et al., 2001; Taveggia et al., 2005).
Localization (secreted) of Nrg1 in cleavage
1) Confidence 0.79 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0.15 Pain Relevance 0
In this study we demonstrate that Type III Nrg1, acting as a receptor for ErbB4, controls the insertion of ?
Localization (acting) of Nrg1
2) Confidence 0.74 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0
Although Types I and II Nrg1 are either directly secreted or released after constitutive cleavage, Type III Nrg1 remains membrane tethered as a result of its unique N-terminal transmembrane domain (Wang et al., 2001; Taveggia et al., 2005).
Localization (released) of Nrg1 in cleavage
3) Confidence 0.74 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0.14 Pain Relevance 0.03
7* nAChR or other receptors, then modulation of Type III Nrg1 signaling in sensory axons could contribute to adaptive physiological changes or to pathological changes in sensory transduction (Bermingham-McDonogh et al., 1997; Kerber et al., 2003).
Localization (modulation) of Nrg1
4) Confidence 0.74 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0.21 Pain Relevance 0.24
We demonstrate that Type III Nrg1 back signaling regulates the surface expression of ?
Localization (signaling) of Nrg1
5) Confidence 0.74 Published 2008 Journal The Journal of Cell Biology Section Abstract Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0.05
Our major findings supporting this conclusion are the following: genetic disruption of Type III Nrg1 affects surface ?
Localization (disruption) of Nrg1
6) Confidence 0.74 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0
Type III Nrg1 back signaling increases surface expression of ?
Localization (signaling) of Nrg1
7) Confidence 0.74 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0.04
Similarly, KU-32 significantly decreased neuregulin 1-induced degeneration of myelinated Schwann cell DRG neuron co-cultures prepared from WT (wild-type) mice.
Localization (decreased) of neuregulin in neuron
8) Confidence 0.51 Published 2010 Journal ASN NEURO Section Abstract Doc Link PMC2919983 Disease Relevance 0.95 Pain Relevance 0.17
The pathways activated by established Schwann cell signals, such as cAMP and neuregulin, are actively being clarified as exemplified by the work on GPR126 and NF-?
Localization (cAMP) of neuregulin in Schwann cell
9) Confidence 0.45 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948355 Disease Relevance 0.33 Pain Relevance 0.17
and NRG1, the cleavage of IL-1R2 was not reduced in BACE deficient cells.
Localization (cleavage) of NRG1 in cleavage
10) Confidence 0.45 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.07 Pain Relevance 0.04
The isoform III, unlike the Ig-like domain of type I NRG1, is not secreted and contains a cysteine-rich domain (CRD).
Neg (not) Localization (secreted) of type I NRG1
11) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0
We demonstrate here that NRG1 realigns vimentin-positive but does not significantly alter BLBP-positive radial glia.
Localization (realigns) of NRG1 in radial
12) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0
Radial glial morphology is improved in the presence of an exogenous secreted form of NRG1
Localization (form) of NRG1 in Radial
13) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0.08 Pain Relevance 0
Radial glial morphology is improved in the presence of an exogenous secreted form of NRG1
Localization (secreted) of NRG1 in Radial
14) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0.08 Pain Relevance 0
We found no improvement of the radial glial scaffold: with a degree of deviation of 20.51 for vimentin and 10.91 for BLBP, suggesting that the morphology of radial glia in presence of type III NRG1 was similar to MAM slices cultured in plain medium (Figure 6D,H).
Localization (presence) of type III NRG1 in radial
15) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0
To assess whether NRG1 acts similarly on both vimentin+ and BLBP+ radial glia, organotypic slices were exposed for 2 DIC to NRG1, and the degrees of deviation computed for vimentin+ and BLBP+ radial glial processes (see Table 1).
Localization (acts) of NRG1 in radial associated with disseminated intravascular coagulation
16) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0.15 Pain Relevance 0
The percent of vimentin+ radial glial processes expressing BLBP in presence of NRG1 while blocking erbB3, erbB4 or Pi3K was similar to control (Figure 6I, Table 2).


Localization (presence) of NRG1 in radial
17) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0.05 Pain Relevance 0
A number of MAM treated slices were co-cultured with: (1) HEK 293T cells, transfected with the mouse reelin cDNA construct pCrl [43], which produces and secretes the full length reelin protein [44], [39], (2) HEK 293T cells, transfected with the type I NRG1 encoding plasmid (NRG1-Ig), which secretes the full length of the isoform type I NRG1 [45] and (3) HEK 293T cells, transfected with the type III NRG1 (NRG1-CRD), which express a non-secreted/membrane type III NRG1 [45].
Localization (secretes) of NRG1
18) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0.08 Pain Relevance 0.03
Migration into the CP was not improved in any of the conditions supplying exogenous NRG1: recombinant NRG1 (1 nM w/o forskoline, or 30 nM), co-culture with cell lines expressing the secreted form of type I NRG1 (Ig-NRG1 cells) or the membrane form of type III NRG1 (CRD-NRG1 cells).
Localization (secreted) of type I NRG1
19) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0.07 Pain Relevance 0
E24 MAM slices were co-cultured with HEK cells secreting the full length of type I NRG1 (Ig-NRG1 cells).
Localization (secreting) of type I NRG1
20) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0.06 Pain Relevance 0

General Comments

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