INT158057

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Context Info
Confidence 0.15
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (EDNRA) signal transduction (EDNRA) aging (EDNRA)
plasma membrane (EDNRA) signal transducer activity (EDNRA)
Anatomy Link Frequency
TM3 2
EDNRA (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 9 97.84 Very High Very High Very High
qutenza 40 79.44 Quite High
Potency 1 55.28 Quite High
spastic colon 1 36.36 Quite Low
ASIC 1 22.48 Low Low
dorsal root ganglion 22 5.00 Very Low Very Low Very Low
bradykinin 10 5.00 Very Low Very Low Very Low
nociceptor 6 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Functional Bowel Disorder 1 36.36 Quite Low
Ganglion Cysts 23 5.00 Very Low Very Low Very Low
Nociception 7 5.00 Very Low Very Low Very Low
Hyperalgesia 5 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Neuropathic Pain 4 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Reprotox - General 1 1 5.00 Very Low Very Low Very Low
Cancer 1 5.00 Very Low Very Low Very Low
Inflammatory Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicated an extended antagonist binding pocket in the TM portion of the receptor, which is conceived crucial for TM3 and 6 arrangement and leads to G protein-coupled receptor activation.
Positive_regulation (leads) of Positive_regulation (activation) of protein-coupled receptor in TM3 associated with antagonist
1) Confidence 0.15 Published 2009 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19218528 Disease Relevance 0 Pain Relevance 0.15
From the data presented above, stimulation of the Gq-coupled ETAR in HEK293 cells could potentiate TRPV1 by a PLC?
Positive_regulation (potentiate) of Positive_regulation (stimulation) of Gq-coupled ETAR
2) Confidence 0.15 Published 2007 Journal Mol Pain Section Body Doc Link PMC2206006 Disease Relevance 0 Pain Relevance 0.25

General Comments

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