INT158077

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Context Info
Confidence 0.35
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Title
Documents 2
Total Number 2
Disease Relevance 0.91
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Gper) endoplasmic reticulum (Gper) plasma membrane (Gper)
signal transducer activity (Gper)
Anatomy Link Frequency
hippocampus 1
Gper (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 3 100.00 Very High Very High Very High
Peripheral sensitization 1 99.36 Very High Very High Very High
Hippocampus 9 98.76 Very High Very High Very High
Pain 2 97.36 Very High Very High Very High
allodynia 2 95.28 Very High Very High Very High
Trigeminal ganglion neurons 2 91.16 High High
agonist 14 89.36 High High
Glutamate 1 74.08 Quite High
unmyelinated 1 74.04 Quite High
c fibre 1 73.52 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 1 99.66 Very High Very High Very High
Pain 1 97.36 Very High Very High Very High
Neuropathic Pain 2 95.28 Very High Very High Very High
Ganglion Cysts 2 90.72 High High
Death 6 82.40 Quite High
Cv Unclassified Under Development 52 67.08 Quite High
Cv General 4 Under Development 1 62.36 Quite High
Stress 1 59.76 Quite High
INFLAMMATION 2 59.44 Quite High
Aging 4 33.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GPR30 is widely expressed in the brain including the hippocampus [14], and a recent study with GPR30 knockout mice shows that GPR30 is not involved in E2 regulation of female reproductive functions known to be mediated by ER?
Neg (not) Regulation (involved) of GPR30 in hippocampus associated with targeted disruption and hippocampus
1) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2799530 Disease Relevance 0.43 Pain Relevance 0.29
Role of the oestrogen receptors GPR30 and ERalpha in peripheral sensitization: relevance to trigeminal pain disorders in women.
Regulation (Role) of GPR30 associated with pain, inflammation and peripheral sensitization
2) Confidence 0.27 Published 2009 Journal Cephalalgia Section Title Doc Link 19220308 Disease Relevance 0.48 Pain Relevance 0.75

General Comments

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