INT158078

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Context Info
Confidence 0.67
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.13
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Gper) endoplasmic reticulum (Gper) plasma membrane (Gper)
signal transducer activity (Gper)
Anatomy Link Frequency
uterus 2
masseter 1
hippocampus 1
Gper (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 4 99.32 Very High Very High Very High
Hippocampus 9 98.88 Very High Very High Very High
allodynia 2 95.44 Very High Very High Very High
agonist 14 94.40 High High
Trigeminal ganglion neurons 2 93.16 High High
c fibre 1 88.32 High High
unmyelinated 1 87.96 High High
Pain 5 86.64 High High
Dopamine 76 82.96 Quite High
Migraine 1 82.56 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 3 99.32 Very High Very High Very High
Targeted Disruption 1 96.96 Very High Very High Very High
Neuropathic Pain 2 95.44 Very High Very High Very High
Ganglion Cysts 2 92.84 High High
Breast Cancer 4 78.56 Quite High
Pain 1 75.00 Quite High
Death 6 72.64 Quite High
Cv Unclassified Under Development 52 72.12 Quite High
Cv General 4 Under Development 1 67.40 Quite High
Stress 1 64.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The GPR30 agonist, but not the ERbeta agonist, rapidly restored VH.
Gene_expression (agonist) of GPR30
1) Confidence 0.67 Published 2009 Journal Gastroenterology Section Body Doc Link 19344720 Disease Relevance 0.13 Pain Relevance 0
GPR30 is widely expressed in the brain including the hippocampus [14], and a recent study with GPR30 knockout mice shows that GPR30 is not involved in E2 regulation of female reproductive functions known to be mediated by ER?
Gene_expression (expressed) of GPR30 in hippocampus associated with targeted disruption and hippocampus
2) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2799530 Disease Relevance 0.43 Pain Relevance 0.35
Treatment with oestrogen increased expression of ERalpha but not GPR30, while masseter inflammation increased GRP30 but not ERalpha.
Gene_expression (expression) of GPR30 in masseter associated with inflammation
3) Confidence 0.59 Published 2009 Journal Cephalalgia Section Abstract Doc Link 19220308 Disease Relevance 0.50 Pain Relevance 0.80
Furthermore, detection of GPR30 RNA expression in PC12 cells suggests that this newly described unique ER could also participate in these responses.
Gene_expression (expression) of GPR30
4) Confidence 0.20 Published 2006 Journal J Mol Signal Section Body Doc Link PMC1769494 Disease Relevance 0 Pain Relevance 0.08
Finally, we examined RNA from these cells to determine if the rat GPR30 RNA was expressed; the lack of a specific Ab for rat GPR30 necessitated this approach.
Gene_expression (expressed) of GPR30
5) Confidence 0.17 Published 2006 Journal J Mol Signal Section Body Doc Link PMC1769494 Disease Relevance 0.08 Pain Relevance 0.03
Compared with control group, hypothalamic GnRH mRNA, ovary GnRH mRNA, pituitary GnRH-R mRNA and uterus ER mRNA expressions in model group were up-regulated significantly, while uterus PR mRNA was down-regulated markedly in model group (P<0.05).
Gene_expression (expressions) of ER mRNA in uterus
6) Confidence 0.02 Published 2009 Journal Zhen Ci Yan Jiu Section Body Doc Link 19526799 Disease Relevance 0 Pain Relevance 0
In comparison with model group, hypothalamic GnRH mRNA, ovary GnRH mRNA, pituitary GnRH-R mRNA and uterus ER mRNA expressions in acupuncture and ELI groups were suppressed significantly (P<0.05), while uterus PR mRNA expressions in the later two groups were up-regulated obviously (P<0.05).
Gene_expression (expressions) of ER mRNA in uterus
7) Confidence 0.02 Published 2009 Journal Zhen Ci Yan Jiu Section Body Doc Link 19526799 Disease Relevance 0 Pain Relevance 0

General Comments

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