INT158079

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Context Info
Confidence 0.31
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.97
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Esr1, Gper) Golgi apparatus (Gper) endoplasmic reticulum (Gper)
enzyme binding (Esr1) DNA binding (Esr1) protein complex (Esr1)
Anatomy Link Frequency
neurons 2
Esr1 (Rattus norvegicus)
Gper (Rattus norvegicus)
Pain Link Frequency Relevance Heat
unmyelinated 2 97.12 Very High Very High Very High
c fibre 2 96.60 Very High Very High Very High
Trigeminal ganglion neurons 4 93.96 High High
agonist 2 91.68 High High
allodynia 4 89.12 High High
Pain 4 75.00 Quite High
Peripheral sensitization 2 75.00 Quite High
Inflammation 6 65.04 Quite High
Migraine 2 48.96 Quite Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 4 93.64 High High
Neuropathic Pain 4 89.12 High High
Pain 2 75.00 Quite High
INFLAMMATION 4 65.04 Quite High
Temporomandibular Joint Disorders 2 5.00 Very Low Very Low Very Low
Headache 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical studies demonstrated the presence of oestrogen receptor alpha (ERalpha) in nuclei of larger neurons and cytoplasm of smaller neurons, and the novel oestrogen receptor G-protein coupled receptor 30 (GPR30) in small diameter neurons that also contained peripherin, a marker of unmyelinated C-fibres.
ERalpha Binding (presence) of GPR30 in neurons associated with c fibre and unmyelinated
1) Confidence 0.31 Published 2009 Journal Cephalalgia Section Abstract Doc Link 19220308 Disease Relevance 0.49 Pain Relevance 0.67
Immunohistochemical studies demonstrated the presence of oestrogen receptor alpha (ERalpha) in nuclei of larger neurons and cytoplasm of smaller neurons, and the novel oestrogen receptor G-protein coupled receptor 30 (GPR30) in small diameter neurons that also contained peripherin, a marker of unmyelinated C-fibres.
ERalpha Binding (presence) of G-protein coupled receptor 30 in neurons associated with c fibre and unmyelinated
2) Confidence 0.27 Published 2009 Journal Cephalalgia Section Abstract Doc Link 19220308 Disease Relevance 0.48 Pain Relevance 0.67

General Comments

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