INT158100

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Context Info
Confidence 0.42
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 4.95
Pain Relevance 4.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
B cell 6
lymph nodes 2
CD86 2
Cd80 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spastic colon 318 99.14 Very High Very High Very High
tolerance 3 98.88 Very High Very High Very High
Inflammation 90 89.68 High High
cytokine 54 67.68 Quite High
abdominal pain 6 16.76 Low Low
chemokine 18 5.00 Very Low Very Low Very Low
nud 9 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
Lasting pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

309 99.14 Very High Very High Very High
INFLAMMATION 93 89.68 High High
Sprains And Strains 3 85.60 High High
Functional Bowel Disorder 15 75.00 Quite High
Microscopic Colitis 21 49.52 Quite Low
Syndrome 6 31.20 Quite Low
Diarrhoea 9 29.04 Quite Low
Congenital Anomalies 24 17.76 Low Low
Abdominal Pain 6 16.76 Low Low
Stress 33 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the slight but significant difference in the over expression of IgG and alpha4beta7, together with the increased expression of CD80 and CD86, suggests that IBS patients also have increased B cell activation in the extra-intestinal lymph nodes.52 In order to explain this cellular infiltrate, Ohman and Simrén47 suggested 2 possible explanations: (1) It could be due to an unregulated mild inflammation or (2) It can reflect a potent inflammatory suppressive process led by activated T lymphocytes.
Positive_regulation (increased) of Gene_expression (expression) of CD80 in lymph nodes associated with inflammation and spastic colon
1) Confidence 0.42 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978389 Disease Relevance 0.31 Pain Relevance 0.64
Bacterial component induced expression of the costimulatory molecule CD80, regarded as important for tolerance induction, is impaired.
Positive_regulation (induced) of Gene_expression (expression) of CD80 associated with tolerance
2) Confidence 0.38 Published 2009 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19222763 Disease Relevance 0.14 Pain Relevance 0.83
The same group52 also described a state of B cell activation, finding increased CD80 and CD86 expression, at least in a subpopulation of IBS patients.
Positive_regulation (increased) of Gene_expression (expression) of CD80 in B cell associated with spastic colon
3) Confidence 0.30 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978389 Disease Relevance 0.28 Pain Relevance 0.50
The same group52 also described a state of B cell activation, finding increased CD80 and CD86 expression, at least in a subpopulation of IBS patients.
Spec (finding) Positive_regulation (finding) of Gene_expression (expression) of CD80 in B cell associated with spastic colon
4) Confidence 0.30 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978389 Disease Relevance 0.28 Pain Relevance 0.51
B cells isolated from blood of IBS patients displayed an amplified activation level as demonstrated by increased cell surface expression of IgG, and also the costimulatory molecules CD80 and CD86.
Positive_regulation (increased) of Gene_expression (expression) of CD80 in CD86 associated with spastic colon
5) Confidence 0.28 Published 2009 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19222763 Disease Relevance 0.22 Pain Relevance 1.02
B cells of IBS patients displayed an impaired ability to increase expression of CD80, but not CD86, in response to both LPS as well as probiotic bacteria stimulations.
Positive_regulation (increase) of Gene_expression (expression) of CD80 in B cells associated with spastic colon
6) Confidence 0.28 Published 2009 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19222763 Disease Relevance 0.20 Pain Relevance 1.00

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