INT15812

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Context Info
Confidence 0.30
First Reported 1991
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 8.77
Pain Relevance 6.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CALCB) extracellular region (CALCB)
Anatomy Link Frequency
macrophages 1
spinal cord 1
eosinophils 1
nerves 1
lymphocytes 1
CALCB (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 17 100.00 Very High Very High Very High
substance P 6 100.00 Very High Very High Very High
calcitonin gene related peptide 6 100.00 Very High Very High Very High
Calcitonin gene-related peptide 1 100.00 Very High Very High Very High
c fibre 9 99.98 Very High Very High Very High
qutenza 13 99.82 Very High Very High Very High
Spinal cord 7 99.82 Very High Very High Very High
Peripheral nervous system 6 99.62 Very High Very High Very High
Inflammation 13 98.22 Very High Very High Very High
intrathecal 2 95.00 High High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 10 99.48 Very High Very High Very High
Edema 4 98.84 Very High Very High Very High
INFLAMMATION 8 98.22 Very High Very High Very High
Hyperalgesia 8 97.40 Very High Very High Very High
Neurogenic Inflammation 5 97.04 Very High Very High Very High
Injury 3 94.64 High High
Infection 13 94.20 High High
Hypersensitivity 5 93.32 High High
Sneezing 16 90.68 High High
Pain 59 89.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Excitatory NANC (e-NANC) bronchoconstrictor responses are believed to be mediated by the release of sensory neuropeptides from a subpopulation of non-myelinated C-fibre primary afferent neurones in the airways. e-NANC nerves, which release tachykinins such as substance P (SP), neurokinin A (NKA) and the peptide calcitonin gene-related peptide (CGRP, produced as a result of alternative splicing of the calcitonin gene) are selectively degenerated by the nerve toxin capsaicin (an extract from hot peppers), with the subsequent abolition of the e-NANC responses.
Localization (release) of calcitonin gene in nerves associated with c fibre, qutenza, neuropeptide, calcitonin gene-related peptide and substance p
1) Confidence 0.30 Published 1991 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 1764811 Disease Relevance 0.05 Pain Relevance 0.43
Activation of the nervi nervorum in the peripheral nervous system also leads to the release of calcitonin gene related peptide, substance P and nitric oxide.
Localization (release) of calcitonin gene in peripheral nervous system associated with calcitonin gene related peptide, peripheral nervous system and substance p
2) Confidence 0.18 Published 2009 Journal Med. Hypotheses Section Abstract Doc Link 19635651 Disease Relevance 0.97 Pain Relevance 0.90
Via axon reflex inflammatory neuropeptides including the tachykinins substance P (SP) and neurokinin A (NKA) and the calcitonin gene related peptide are released, leading to vasodilatation, increased vascular permeability (concept of "neurogenic inflammation"), glandular activation, leukocyte recruitment and differentiation of immune cells including mast cells, eosinophils, lymphocytes and macrophages.
Localization (released) of calcitonin gene in lymphocytes associated with calcitonin gene related peptide, inflammation, neuropeptide, neurogenic inflammation, edema, increased venous pressure under development and substance p
3) Confidence 0.18 Published 2009 Journal Swiss Med Wkly Section Abstract Doc Link 19169901 Disease Relevance 1.39 Pain Relevance 0.45
SO2-induced bronchoconstriction was associated with release of Calcitonin Gene Related Peptide, suggesting activation of capsaicin sensitive sensory nerves.
Localization (release) of Calcitonin Gene in sensory nerves associated with qutenza
4) Confidence 0.16 Published 1995 Journal G Ital Med Lav Section Abstract Doc Link 8991827 Disease Relevance 0 Pain Relevance 0.26
Local changes may influence neural plasticity at the associated segmental level of the spinal cord and the release of neuropeptides (such as calcitonin gene–related peptide) that increase perfusion 37,38.
Localization (release) of calcitonin gene in spinal cord associated with neuropeptide and spinal cord
5) Confidence 0.13 Published 2007 Journal Current Oncology Section Body Doc Link PMC1891200 Disease Relevance 0.72 Pain Relevance 1.01
Via axon reflex inflammatory neuropeptides including the tachykinins substance P (SP) and neurokinin A (NKA) and the calcitonin gene related peptide are released, leading to vasodilatation, increased vascular permeability (concept of "neurogenic inflammation"), glandular activation, leukocyte recruitment and differentiation of immune cells including mast cells, eosinophils, lymphocytes and macrophages.
Localization (released) of calcitonin gene in macrophages associated with calcitonin gene related peptide, inflammation, neuropeptide, neurogenic inflammation, edema, increased venous pressure under development and substance p
6) Confidence 0.06 Published 2009 Journal Swiss Med Wkly Section Abstract Doc Link 19169901 Disease Relevance 1.39 Pain Relevance 0.45
Via axon reflex inflammatory neuropeptides including the tachykinins substance P (SP) and neurokinin A (NKA) and the calcitonin gene related peptide are released, leading to vasodilatation, increased vascular permeability (concept of "neurogenic inflammation"), glandular activation, leukocyte recruitment and differentiation of immune cells including mast cells, eosinophils, lymphocytes and macrophages.
Localization (released) of calcitonin gene in mast cells associated with calcitonin gene related peptide, inflammation, neuropeptide, neurogenic inflammation, edema, increased venous pressure under development and substance p
7) Confidence 0.06 Published 2009 Journal Swiss Med Wkly Section Abstract Doc Link 19169901 Disease Relevance 1.39 Pain Relevance 0.45
Via axon reflex inflammatory neuropeptides including the tachykinins substance P (SP) and neurokinin A (NKA) and the calcitonin gene related peptide are released, leading to vasodilatation, increased vascular permeability (concept of "neurogenic inflammation"), glandular activation, leukocyte recruitment and differentiation of immune cells including mast cells, eosinophils, lymphocytes and macrophages.
Localization (released) of calcitonin gene in eosinophils associated with calcitonin gene related peptide, inflammation, neuropeptide, neurogenic inflammation, edema, increased venous pressure under development and substance p
8) Confidence 0.06 Published 2009 Journal Swiss Med Wkly Section Abstract Doc Link 19169901 Disease Relevance 1.39 Pain Relevance 0.45
and C fibres releases vasoactive neuropeptides, as well as proinflammatory agents like the calcitonin gene?
Localization (releases) of calcitonin gene associated with c fibre and neuropeptide
9) Confidence 0.02 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2432047 Disease Relevance 0.75 Pain Relevance 0.54
Functionally, SD-282 decreased capsaicin-induced release of calcitonin gene related peptide in an in vitro skin release assay, consistent with a role for p38 MAPK in peripheral nerve function.
Localization (release) of calcitonin gene in skin associated with calcitonin gene related peptide and qutenza
10) Confidence 0.01 Published 2004 Journal Pain Section Abstract Doc Link 15363871 Disease Relevance 0.71 Pain Relevance 1.42

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