INT158123

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Context Info
Confidence 0.46
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 15.27
Pain Relevance 2.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL5A2) molecular_function (COL5A2)
Anatomy Link Frequency
fibroblasts 6
tendon 4
fat 2
osteoblast 2
extracellular matrix 2
COL5A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 74 99.82 Very High Very High Very High
Cannabinoid 26 97.82 Very High Very High Very High
Hippocampus 2 97.26 Very High Very High Very High
cytokine 78 96.44 Very High Very High Very High
Regional anesthesia 1 96.28 Very High Very High Very High
Inflammation 185 96.04 Very High Very High Very High
fibrosis 41 95.84 Very High Very High Very High
local anesthetic 1 92.76 High High
corticosteroid 11 90.08 High High
metalloproteinase 69 87.76 High High
Disease Link Frequency Relevance Heat
Osteoporosis 174 100.00 Very High Very High Very High
Primary Sclerosing Cholangitis 75 100.00 Very High Very High Very High
Uterine Fibroids 360 99.92 Very High Very High Very High
Injury 126 99.86 Very High Very High Very High
Cirrhosis 66 99.84 Very High Very High Very High
Osteogenesis Imperfecta 10 99.84 Very High Very High Very High
Frailty 5 99.48 Very High Very High Very High
Wrinkles 16 99.30 Very High Very High Very High
Bone Cancer 11 98.62 Very High Very High Very High
Tendinopathy 18 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Predisposing mechanical or ischemic factors could modify tendon collagen composition, characterized by both increased amounts of types III and V fibrils and diminished synthesis of type I collagen, which leads to abnormal fibrillogenesis and production of less resistant fibers that are more susceptible to rupture.
Negative_regulation (diminished) of Gene_expression (synthesis) of collagen in tendon associated with rupture
1) Confidence 0.46 Published 2008 Journal Clinics Section Body Doc Link PMC2664193 Disease Relevance 0.41 Pain Relevance 0
We hypothesized that bupivacaine would decrease cell proliferation and production of extracellular matrix components collagen and proteoglycan in healthy human tenocytes in culture.
Negative_regulation (decrease) of Gene_expression (production) of collagen in extracellular matrix
2) Confidence 0.42 Published 2009 Journal Orthopedics Section Abstract Doc Link 19226039 Disease Relevance 0 Pain Relevance 0.19
Despite its high prevalence worldwide, the exact etiology PTTD has not been conclusively determined.1 Epidemiological studies have shown that trauma does not play a significant role in tendon rupture; however, ageing, obesity and systemic hypertension seem to be associated with PTTD.3 It has also been proposed that tendinopathy is related to changes in matrix turnover, including modifications of collagen synthesis, which could interfere with the physical and structural properties of normal tendons.
Negative_regulation (interfere) of Gene_expression (synthesis) of collagen in tendon associated with aging, rupture, hypertension, obesity, injury, tendinopathy and posterior tibial tendon dysfunction
3) Confidence 0.39 Published 2008 Journal Clinics Section Body Doc Link PMC2664193 Disease Relevance 1.67 Pain Relevance 0.15
Wong et al found a dexamethasone-induced reduction in collagen synthesis, cell proliferation and proteoglycan synthesis in passaged human patellar tenocytes [23,24].
Negative_regulation (reduction) of Gene_expression (synthesis) of collagen associated with dexamethasone
4) Confidence 0.11 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2515295 Disease Relevance 0.19 Pain Relevance 0.20
The main frequent changes observed among women aged between 30 and 60 years due to the natural and continuing aging process are the appearance of small wrinkles, atrophy of subcutaneous fat, and decreases in collagen and elastin production.
Negative_regulation (decreases) of Gene_expression (production) of collagen in fat associated with aging, wrinkles and frailty
5) Confidence 0.08 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2946856 Disease Relevance 0.64 Pain Relevance 0.08
This well known pattern was not evident in the fatal PQ intoxication cases included in this study since all deaths were observed within hours to few days, not allowing enough time for the massive synthesis and deposition of collagen to occur.
Negative_regulation (deposition) of Gene_expression (synthesis) of collagen associated with poisoning
6) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745573 Disease Relevance 0.59 Pain Relevance 0.19
have profound effects on collagen metabolism in fibroblasts in vitro by downregulating the synthesis of collagen [18,20,31].
Negative_regulation (downregulating) of Gene_expression (synthesis) of collagen in fibroblasts
7) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875629 Disease Relevance 0.10 Pain Relevance 0.26
Thus, cannabinoid-induced suppression of MMP-2 could be a mediator of the induction of a more quiescent phenotype, leading to reduced collagen synthesis.
Negative_regulation (reduced) of Gene_expression (synthesis) of collagen associated with cannabinoid
8) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253501 Disease Relevance 1.05 Pain Relevance 0.39
ATRA exposure reduced collagen production
Negative_regulation (reduced) of Gene_expression (production) of collagen
9) Confidence 0.05 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.96 Pain Relevance 0
Exposure of leiomyoma cells to ATRA resulted in a dose-dependent inhibition of templates for specific ECM protein production including collagen 1, collagen 4, fibronectin and versican.
Negative_regulation (inhibition) of Gene_expression (production) of collagen associated with uterine fibroids
10) Confidence 0.03 Published 2008 Journal Clinical Endocrinology Section Abstract Doc Link PMC2610401 Disease Relevance 1.38 Pain Relevance 0
ATRA exposure reduced collagen production
Negative_regulation (exposure) of Gene_expression (production) of collagen
11) Confidence 0.03 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.96 Pain Relevance 0
The expression of osteopontin by osteoblast precursors and collagen type-1 by more mature osteoblasts was suppressed by the glucocorticoid in both cases to levels that were lower than the untreated control, suggesting that glucocorticoids not only inhibit differentiation, but may actually induce de-differentiation of osteoblast precursors and osteoblasts.
Negative_regulation (suppressed) of Gene_expression (expression) of collagen in osteoblast associated with osteoporosis
12) Confidence 0.03 Published 2010 Journal European Journal of Haematology Section Body Doc Link PMC2970902 Disease Relevance 0.93 Pain Relevance 0.03
We found collagen type 11a1 expression to be highly specific for the PSC and almost absent in HSC.
Negative_regulation (absent) of Neg (absent) Gene_expression (expression) of collagen associated with cirrhosis and primary sclerosing cholangitis
13) Confidence 0.03 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 1.28 Pain Relevance 0
However the reduced levels of both collagen and calcium compromise the bone strength leading to risk of fracture.
Negative_regulation (reduced) of Gene_expression (levels) of collagen
14) Confidence 0.01 Published 2004 Journal International Journal of Medical Sciences Section Body Doc Link PMC1074710 Disease Relevance 1.38 Pain Relevance 0.03
has been reported to inhibit collagen synthesis [64] and increase MMP synthesis in gingival fibroblasts [65-67], which contributes to gingival breakdown.
Negative_regulation (inhibit) of Gene_expression (synthesis) of collagen in fibroblasts
15) Confidence 0.01 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.09 Pain Relevance 0.03
Interestingly enough, the differentiation of an antifibrotic myofibroblast phenotype in response to tissue injury could inhibit collagen production as well as fibroblast proliferation.
Negative_regulation (inhibit) of Gene_expression (production) of collagen in fibroblast associated with injury
16) Confidence 0.01 Published 2010 Journal Theor Biol Med Model Section Body Doc Link PMC2945962 Disease Relevance 0.65 Pain Relevance 0.12
The same research group has reported pronase E-derived hydrolysate peptide of 1821 Da from a sea horse, Hippocampus kuda Bleeler.This peptide has been checked for its induction of differentiation of osteoblastic MG-63 and chondrocytic SW-1353 cells by measuring ALP activity, mineralization, and collagen synthesis.
Negative_regulation (measuring) of Gene_expression (synthesis) of collagen in Hippocampus associated with osteoporosis and hippocampus
17) Confidence 0.01 Published 2010 Journal Biochemistry Research International Section Body Doc Link PMC3004377 Disease Relevance 0.23 Pain Relevance 0.15
The most common primary bone disorder leading to OP is osteogenesis imperfecta (OI), a structural genetic defect in the quantity or quality of bone type 1 collagen production.
Negative_regulation (defect) of Gene_expression (production) of collagen associated with osteogenesis imperfecta, osteoporosis and bone cancer
18) Confidence 0.01 Published 2009 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2768686 Disease Relevance 1.58 Pain Relevance 0.11
The accumulated AGEs can reduce proteoglycan and collagen synthesis by chondrocytes and lead to stiffness and fragility of articular cartilage [5].
Negative_regulation (reduce) of Gene_expression (synthesis) of collagen in articular cartilage
19) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2990994 Disease Relevance 1.20 Pain Relevance 0.29

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