INT158124

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 136
Total Number 136
Disease Relevance 72.30
Pain Relevance 12.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL5A2) molecular_function (COL5A2)
Anatomy Link Frequency
tendon 10
fibroblasts 9
cartilage 6
extracellular matrix 4
chondrocytes 3
COL5A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 377 100.00 Very High Very High Very High
dexamethasone 218 99.56 Very High Very High Very High
Inflammation 844 99.52 Very High Very High Very High
Osteoarthritis 1233 99.20 Very High Very High Very High
aspirin 167 99.00 Very High Very High Very High
Dismenorea 5 98.96 Very High Very High Very High
cytokine 560 98.88 Very High Very High Very High
fibrosis 197 98.60 Very High Very High Very High
rheumatoid arthritis 171 98.00 Very High Very High Very High
Cannabinoid 52 97.66 Very High Very High Very High
Disease Link Frequency Relevance Heat
Osteoporosis 287 100.00 Very High Very High Very High
Intervertebral Disk Degeneration 190 99.96 Very High Very High Very High
Uterine Fibroids 1080 99.92 Very High Very High Very High
Targeted Disruption 32 99.88 Very High Very High Very High
Cancer 514 99.84 Very High Very High Very High
Emphysema 52 99.84 Very High Very High Very High
Osteogenesis Imperfecta 10 99.84 Very High Very High Very High
Pre-term Labor 5 99.76 Very High Very High Very High
Injury 699 99.74 Very High Very High Very High
Posterior Tibial Tendon Dysfunction 300 99.62 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite its high prevalence worldwide, the exact etiology PTTD has not been conclusively determined.1 Epidemiological studies have shown that trauma does not play a significant role in tendon rupture; however, ageing, obesity and systemic hypertension seem to be associated with PTTD.3 It has also been proposed that tendinopathy is related to changes in matrix turnover, including modifications of collagen synthesis, which could interfere with the physical and structural properties of normal tendons.
Gene_expression (synthesis) of collagen in tendon associated with aging, rupture, hypertension, obesity, injury, tendinopathy and posterior tibial tendon dysfunction
1) Confidence 0.69 Published 2008 Journal Clinics Section Body Doc Link PMC2664193 Disease Relevance 1.66 Pain Relevance 0.15
The authors concluded that this different collagen expression pattern found in PTTD was a possible explanation for abnormal fiber synthesis, decreased resistance to mechanical injuries and a predisposition to tendon ruptures.
Gene_expression (expression) of collagen in tendon associated with rupture, injury and posterior tibial tendon dysfunction
2) Confidence 0.69 Published 2008 Journal Clinics Section Body Doc Link PMC2664193 Disease Relevance 0.55 Pain Relevance 0
This shows a dynamic process involving new synthesis of collagen and modification of the extracellular matrix composition.
Gene_expression (synthesis) of collagen in extracellular matrix
3) Confidence 0.69 Published 2008 Journal Clinics Section Body Doc Link PMC2664193 Disease Relevance 0.62 Pain Relevance 0
As previously described6, the present study shows diminution of type I collagen expression and increased synthesis of types III and V fibrils in PTTD.
Gene_expression (expression) of collagen associated with posterior tibial tendon dysfunction
4) Confidence 0.61 Published 2008 Journal Clinics Section Body Doc Link PMC2664193 Disease Relevance 0.45 Pain Relevance 0.04
Predisposing mechanical or ischemic factors could modify tendon collagen composition, characterized by both increased amounts of types III and V fibrils and diminished synthesis of type I collagen, which leads to abnormal fibrillogenesis and production of less resistant fibers that are more susceptible to rupture.
Gene_expression (synthesis) of collagen in tendon associated with rupture
5) Confidence 0.61 Published 2008 Journal Clinics Section Body Doc Link PMC2664193 Disease Relevance 0.41 Pain Relevance 0
In addition, Teodoro et al. (2004)8 have reported that type V collagen can be synthesized mainly by smooth muscular cells from blood vessels.
Gene_expression (synthesized) of collagen in blood vessels
6) Confidence 0.61 Published 2008 Journal Clinics Section Body Doc Link PMC2664193 Disease Relevance 0.54 Pain Relevance 0
The third point that we should emphasize is that all obtained tendons in our study were submitted to collagen evaluation by immunofluorescence, including the macroscopic normal segments.
Gene_expression (evaluation) of collagen in tendons
7) Confidence 0.60 Published 2008 Journal Clinics Section Body Doc Link PMC2664193 Disease Relevance 0.37 Pain Relevance 0.13
The role of collagen in the tendon has been studied extensively, and rotator cuff injury is one of the best examples of a tendon rupture syndrome related to abnormal collagen synthesis.13,14 It was admitted that tendon degeneration could be caused by repetitive microinjuries, which are subsequently repaired by removal of damaged matrix and deposition of newly abnormal synthesized collagen liable to rupture.13,14
Gene_expression (synthesis.13,14) of collagen in tendon associated with syndrome, rupture and rotator cuff tears
8) Confidence 0.60 Published 2008 Journal Clinics Section Body Doc Link PMC2664193 Disease Relevance 0.79 Pain Relevance 0.03
Beneath the flap, corneal collagen bundles seemed to be uniform and regular, but upon birefringence studies, some degree of fiber dearrangements could be observed.
Gene_expression (bundles) of collagen
9) Confidence 0.58 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2533033 Disease Relevance 0.19 Pain Relevance 0
We hypothesized that bupivacaine would decrease cell proliferation and production of extracellular matrix components collagen and proteoglycan in healthy human tenocytes in culture.
Gene_expression (production) of collagen in extracellular matrix
10) Confidence 0.58 Published 2009 Journal Orthopedics Section Abstract Doc Link 19226039 Disease Relevance 0 Pain Relevance 0.19
The role of collagen in the tendon has been studied extensively, and rotator cuff injury is one of the best examples of a tendon rupture syndrome related to abnormal collagen synthesis.13,14 It was admitted that tendon degeneration could be caused by repetitive microinjuries, which are subsequently repaired by removal of damaged matrix and deposition of newly abnormal synthesized collagen liable to rupture.13,14
Gene_expression (synthesized) of collagen in tendon associated with syndrome, rupture and rotator cuff tears
11) Confidence 0.54 Published 2008 Journal Clinics Section Body Doc Link PMC2664193 Disease Relevance 0.71 Pain Relevance 0.03
In the same report the authors also described an increase in type V collagen in neovascularization and tissue remodeling, similar as occurred in our study in PTTD, where the type V collagen was found distributed all over the tendon, but mainly in the perivascular region.
Gene_expression (found) of collagen in tendon associated with posterior tibial tendon dysfunction
12) Confidence 0.53 Published 2008 Journal Clinics Section Body Doc Link PMC2664193 Disease Relevance 0.46 Pain Relevance 0
To evaluate the acute effects of laser in situ keratomileusis (LASIK) upon the synthesis of proteoglycans (PGs) and collagen fibril organization in human corneal explants.


Gene_expression (synthesis) of collagen
13) Confidence 0.52 Published 2007 Journal Molecular Vision Section Abstract Doc Link PMC2533033 Disease Relevance 0 Pain Relevance 0
Fibrillogenesis in posterior tibial tendon dysfunction is altered due to higher expression of types III and V collagen and a decreased amount of collagen type I, which renders the originating fibrils structurally less resistant to mechanical forces.



Gene_expression (expression) of collagen in tendon associated with posterior tibial tendon dysfunction
14) Confidence 0.47 Published 2008 Journal Clinics Section Abstract Doc Link PMC2664193 Disease Relevance 0.43 Pain Relevance 0
The inflammatory process is negligible in diseased tendons, where type I collagen is found in minor proportion, diffusely distributed, and grossly surrounded by type III fibrils.
Gene_expression (found) of collagen in tendons associated with inflammation
15) Confidence 0.47 Published 2008 Journal Clinics Section Body Doc Link PMC2664193 Disease Relevance 0.36 Pain Relevance 0.05
The etched bone surface still moist with the collagen exposed is wetted by amphiphilic monomers.
Gene_expression (exposed) of collagen
16) Confidence 0.45 Published 2003 Journal Biomed Eng Online Section Body Doc Link PMC222922 Disease Relevance 0.07 Pain Relevance 0
The non-selective cyclooxygenase (COX) inhibitor indomethacin, clinically used to delay premature labour, inhibited collagen contraction.
Gene_expression (contraction) of collagen associated with pre-term labor
17) Confidence 0.25 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2645409 Disease Relevance 0.27 Pain Relevance 0.18
For each condition, collagen contraction was determined in quadruplicate, at a minimum.
Gene_expression (contraction) of collagen
18) Confidence 0.25 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2645409 Disease Relevance 0 Pain Relevance 0
The mean ACTB normalised RNA quantities for treated and control ± SEM, for F2R were 0.215 ± 0.025, 0.09083 ± 0.01282, this is graphically represented in Figure 3C), with a resultant relative fold increase of 2.36 in the thrombin treated versus the untreated collagen gels.


Gene_expression (gels) of collagen
19) Confidence 0.25 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2645409 Disease Relevance 0 Pain Relevance 0
These procollagen forms undergo processing to the mature form with release of N- and C- terminal propeptides that are indicative of the amount of newly synthesized collagen.
Gene_expression (synthesized) of collagen
20) Confidence 0.25 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716783 Disease Relevance 0.09 Pain Relevance 0.09

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox