INT158132

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Context Info
Confidence 0.02
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.54
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (IPMK) nucleus (IPMK) kinase activity (IPMK)
Anatomy Link Frequency
thyroid 1
IPMK (Homo sapiens)
Pain Link Frequency Relevance Heat
abdominal pain 2 25.00 Low Low
COX2 1 16.72 Low Low
COX-2 inhibitor 1 13.04 Low Low
withdrawal 8 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Neuropeptide 1 5.00 Very Low Very Low Very Low
Catecholamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 14 98.04 Very High Very High Very High
Thyroid Neoplasm 169 95.60 Very High Very High Very High
Disease 81 90.40 High High
Liver Failure 1 86.28 High High
Disease Progression 1 84.32 Quite High
Toxicity 2 82.60 Quite High
Diarrhoea 6 62.64 Quite High
Hypertension 2 61.60 Quite High
Exanthema 2 54.56 Quite High
Renal Cancer 1 51.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AMG-706 Finally, in a third abstract reported at the 2007 annual meeting of the American Society of Clinical Oncology, AMG-706, another multikinase inhibitor (VEGF/PDGF receptors, Kit and RET), was studied in a phase II trial of patients with advanced differentiated thyroid cancer or medullary thyroid cancer.
Negative_regulation (inhibitor) of multikinase in thyroid associated with thyroid neoplasm
1) Confidence 0.02 Published 2010 Journal Journal of Thyroid Research Section Body Doc Link PMC2956973 Disease Relevance 1.15 Pain Relevance 0
Sorafenib (Nexavar) is an orally active multikinase inhibitor that is approved in the EU for the treatment of hepatocellular carcinoma.
Negative_regulation (inhibitor) of multikinase associated with hepatocellular cancer
2) Confidence 0.01 Published 2009 Journal Drugs Section Abstract Doc Link 19228077 Disease Relevance 0.39 Pain Relevance 0

General Comments

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