INT158136

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Context Info
Confidence 0.26
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.50
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (FGFR2) Golgi apparatus (FGFR2) cytoplasmic membrane-bounded vesicle (FGFR2)
plasma membrane (FGFR2) nucleus (FGFR2) cell-cell signaling (FGFR2)
Anatomy Link Frequency
chondrocytes 1
bone marrow 1
kidney 1
FGFR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 78 89.36 High High
Arthritis 52 88.80 High High
palliative 4 82.88 Quite High
chemokine 16 38.84 Quite Low
Chronic pancreatitis 22 5.00 Very Low Very Low Very Low
Inflammation 17 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Osteoarthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 62 100.00 Very High Very High Very High
Breast Cancer 4 100.00 Very High Very High Very High
Hypoxia 2 98.56 Very High Very High Very High
Cancer 37 94.28 High High
Rheumatoid Arthritis 78 89.36 High High
Seronegative Spondarthritis 48 88.80 High High
Osteoarthritis 29 83.36 Quite High
Pancreatic Cancer 112 83.12 Quite High
Wound Healing 18 82.76 Quite High
Reprotox - General 1 2 82.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Growth factor receptors emerged as target for effective therapy providing significant clinical benefit, for example epidermal growth factor receptor 2 or human epidermal growth factor receptor 2 + breast cancer disease has been routinely treated with trastuzumab, a monoclonal antibody, with significant survival benefit.
factor receptor 2 Binding (treated) of associated with breast cancer and disease
1) Confidence 0.26 Published 2009 Journal Am J Hosp Palliat Care Section Abstract Doc Link 19229068 Disease Relevance 0.65 Pain Relevance 0.15
Growth factor receptors emerged as target for effective therapy providing significant clinical benefit, for example epidermal growth factor receptor 2 or human epidermal growth factor receptor 2 + breast cancer disease has been routinely treated with trastuzumab, a monoclonal antibody, with significant survival benefit.
factor receptor 2 Binding (treated) of associated with breast cancer and disease
2) Confidence 0.26 Published 2009 Journal Am J Hosp Palliat Care Section Abstract Doc Link 19229068 Disease Relevance 0.65 Pain Relevance 0.15
Associations were identified in SNPs in FGFR2 (two studies), TNRC9 (two studies), at haplotype blocks rs13387042 and rs3817198 (which do not contain known genes, one study each), MAP3K1 (one study) and LSP1 (one study).
FGFR2 Binding (Associations) of
3) Confidence 0.24 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717811 Disease Relevance 0.97 Pain Relevance 0
However, staining for KGFR was markedly higher after surgery in the perichondrial area including the proliferating chondrocytes (TableĀ 2).


KGFR Binding (staining) of in chondrocytes
4) Confidence 0.18 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2896696 Disease Relevance 0.13 Pain Relevance 0
Human Nbp35 forms a complex with its close homologue human Cfd1 in vivo, suggesting that a heteromeric P-loop NTPase complex is required for cytosolic Fe?
Cfd1 Binding (complex) of
5) Confidence 0.12 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.20 Pain Relevance 0
It is conceivable that the HSPG/FGF receptor complex can facilitate FGF-2 signaling, but may not be strictly required for binding of FGF-2 to its receptor; it only increases the affinity of the FGF-2/FGF receptor interaction to a certain degree.
FGF receptor Binding (interaction) of
6) Confidence 0.09 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.39 Pain Relevance 0
It is conceivable that the HSPG/FGF receptor complex can facilitate FGF-2 signaling, but may not be strictly required for binding of FGF-2 to its receptor; it only increases the affinity of the FGF-2/FGF receptor interaction to a certain degree.
FGF receptor Binding (complex) of
7) Confidence 0.06 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.41 Pain Relevance 0
Using the same antibody as ours, glypican-4 has been shown to be expressed in human kidney and bone marrow stromal and haematopoietic cells;37 54 it is also expressed in development and binds fibroblast growth factor-2.55 56
fibroblast growth factor-2 Binding (binds) of in kidney
8) Confidence 0.03 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2563418 Disease Relevance 0.55 Pain Relevance 0.16
Using the same antibody as ours, glypican-4 has been shown to be expressed in human kidney and bone marrow stromal and haematopoietic cells;37 54 it is also expressed in development and binds fibroblast growth factor-2.55 56
fibroblast growth factor-2 Binding (binds) of in bone marrow
9) Confidence 0.01 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2563418 Disease Relevance 0.55 Pain Relevance 0.16

General Comments

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