INT15814

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Context Info
Confidence 0.20
First Reported 1991
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.49
Pain Relevance 3.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CALCB) extracellular region (CALCB)
Anatomy Link Frequency
spinal cord 2
nerves 2
peripheral nervous system 2
skin 2
CALCB (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 3 100.00 Very High Very High Very High
substance P 2 100.00 Very High Very High Very High
calcitonin gene related peptide 2 100.00 Very High Very High Very High
Calcitonin gene-related peptide 1 100.00 Very High Very High Very High
qutenza 9 99.98 Very High Very High Very High
Peripheral nervous system 2 99.88 Very High Very High Very High
Spinal cord 6 99.82 Very High Very High Very High
c fibre 4 98.72 Very High Very High Very High
intrathecal 2 95.32 Very High Very High Very High
Thermal hyperalgesia 4 94.80 High High
Disease Link Frequency Relevance Heat
Hyperalgesia 8 97.72 Very High Very High Very High
Injury 3 95.16 Very High Very High Very High
Infection 2 94.72 High High
Pain 50 91.76 High High
Herpes Zoster 7 88.08 High High
Frailty 1 78.96 Quite High
Nociception 4 71.68 Quite High
Stress 4 60.48 Quite High
Pressure And Volume Under Development 4 60.24 Quite High
Syndrome 1 55.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Excitatory NANC (e-NANC) bronchoconstrictor responses are believed to be mediated by the release of sensory neuropeptides from a subpopulation of non-myelinated C-fibre primary afferent neurones in the airways. e-NANC nerves, which release tachykinins such as substance P (SP), neurokinin A (NKA) and the peptide calcitonin gene-related peptide (CGRP, produced as a result of alternative splicing of the calcitonin gene) are selectively degenerated by the nerve toxin capsaicin (an extract from hot peppers), with the subsequent abolition of the e-NANC responses.
Positive_regulation (degenerated) of in nerve Localization (release) of calcitonin gene in nerves associated with c fibre, qutenza, neuropeptide, calcitonin gene-related peptide and substance p
1) Confidence 0.20 Published 1991 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 1764811 Disease Relevance 0.06 Pain Relevance 0.44
Activation of the nervi nervorum in the peripheral nervous system also leads to the release of calcitonin gene related peptide, substance P and nitric oxide.
Positive_regulation (leads) of Localization (release) of calcitonin gene in peripheral nervous system associated with calcitonin gene related peptide, peripheral nervous system and substance p
2) Confidence 0.11 Published 2009 Journal Med. Hypotheses Section Abstract Doc Link 19635651 Disease Relevance 0.97 Pain Relevance 0.90
Local changes may influence neural plasticity at the associated segmental level of the spinal cord and the release of neuropeptides (such as calcitonin gene–related peptide) that increase perfusion 37,38.
Positive_regulation (increase) of Localization (release) of calcitonin gene in spinal cord associated with neuropeptide and spinal cord
3) Confidence 0.09 Published 2007 Journal Current Oncology Section Body Doc Link PMC1891200 Disease Relevance 0.74 Pain Relevance 1.05
Functionally, SD-282 decreased capsaicin-induced release of calcitonin gene related peptide in an in vitro skin release assay, consistent with a role for p38 MAPK in peripheral nerve function.
Positive_regulation (induced) of Localization (release) of calcitonin gene in skin associated with calcitonin gene related peptide and qutenza
4) Confidence 0.01 Published 2004 Journal Pain Section Abstract Doc Link 15363871 Disease Relevance 0.72 Pain Relevance 1.43

General Comments

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