INT158184

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Context Info
Confidence 0.52
First Reported 2007
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.30
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ARRB2) cytoplasmic membrane-bounded vesicle (ARRB2) plasma membrane (ARRB2)
nucleus (ARRB2) cytoplasm (ARRB2)
Anatomy Link Frequency
plasma 1
ARRB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 5 98.24 Very High Very High Very High
agonist 103 98.16 Very High Very High Very High
Pain 2 97.80 Very High Very High Very High
Morphine 9 96.16 Very High Very High Very High
opioid receptor 1 51.64 Quite High
adenocard 60 50.00 Quite Low
antagonist 17 18.84 Low Low
Inflammation 4 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Thalamus 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 4 98.72 Very High Very High Very High
Pain 2 97.80 Very High Very High Very High
Cancer 13 97.04 Very High Very High Very High
Death 8 96.92 Very High Very High Very High
Breast Cancer 3 75.00 Quite High
Increased Venous Pressure Under Development 3 65.92 Quite High
Vibrio Infection 2 58.56 Quite High
Anaplastic Astrocytoma 3 11.96 Low Low
Disease 6 5.00 Very Low Very Low Very Low
Hypoxia 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, targeting beta-arrestin2 may be useful for treating side effects of opioids as pain relievers for cancer patients.
Localization (targeting) of beta-arrestin2 associated with pain, cancer and opioid
1) Confidence 0.52 Published 2009 Journal Neoplasma Section Abstract Doc Link 19239323 Disease Relevance 1.18 Pain Relevance 1.26
GFP-tagged arrestin 2 did not translocate from the cytosol to the plasma membrane upon agonist stimulation of these two truncated receptors.
Neg (not) Localization (translocate) of arrestin 2 in plasma associated with agonist
2) Confidence 0.02 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.12 Pain Relevance 0.21

General Comments

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