INT158242

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Context Info
Confidence 0.37
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.13
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CCR2) plasma membrane (CCR2) cytoplasm (CCR2)
signal transducer activity (CCR2)
Anatomy Link Frequency
monocyte 4
CCR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 70 100.00 Very High Very High Very High
Chronic pancreatitis 20 91.12 High High
abdominal pain 1 89.40 High High
headache 2 88.76 High High
Inflammation 75 80.80 Quite High
cytokine 33 50.00 Quite Low
rheumatoid arthritis 8 44.80 Quite Low
Multiple sclerosis 2 42.32 Quite Low
antagonist 1 21.76 Low Low
Arthritis 3 15.84 Low Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 180 99.12 Very High Very High Very High
Pancreatitis 20 91.12 High High
Vomiting 1 89.80 High High
Abdominal Pain 1 89.40 High High
Headache 2 88.76 High High
Atherosclerosis 2 82.04 Quite High
INFLAMMATION 75 80.80 Quite High
Disease 16 71.04 Quite High
Pancreatic Cancer 10 70.28 Quite High
Cancer 69 68.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Evodiamine and rutaecarpine decreased the LIGHT-induced production of ROS, IL-8, monocyte chemoattractant protein-1 (MCP-1), TNF-alpha, and IL-6, as well as the expression of chemokine receptor (CCR) 1, CCR2 and ICAM-1 and the phosphorylation of the ERK 1/2 and p38 MAPK.
Negative_regulation (decreased) of Gene_expression (expression) of CCR2 in monocyte associated with chemokine
1) Confidence 0.37 Published 2009 Journal J. Cell. Biochem. Section Abstract Doc Link 19241441 Disease Relevance 0.35 Pain Relevance 0.23
Although MDCs displayed unchanged levels of CCR2, PDCs expressed decreased levels of CCR2 both pre and post surgery (pre: median 437, post: median 441) compared to controls (median 602) (Figure 5A).


Negative_regulation (decreased) of Gene_expression (expressed) of CCR2
2) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.66 Pain Relevance 0.41
Expression of CCR2 on monocytes can be downregulated by lipopolysaccharides.
Negative_regulation (downregulated) of Gene_expression (Expression) of CCR2 in monocytes
3) Confidence 0.23 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896663 Disease Relevance 0 Pain Relevance 0.32
MDC and PDC levels of ICOSL and CCR2 pre surgery, correlated with the PDAC patient's clinical outcome
Negative_regulation (levels) of Gene_expression (surgery) of CCR2 associated with adenocarcinoma
4) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 1.12 Pain Relevance 0.16

General Comments

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