INT158258

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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.67
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tnfrsf4)
Anatomy Link Frequency
spinal cord 2
locus coeruleus 1
optic nerves 1
Tnfrsf4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 72 99.50 Very High Very High Very High
Peripheral nerve injury 8 86.40 High High
Neuropathic pain 10 62.68 Quite High
Pain 7 50.00 Quite Low
Locus ceruleus 4 50.00 Quite Low
ketamine 8 21.12 Low Low
Analgesic 2 12.68 Low Low
Dorsal horn 4 6.12 Low Low
Central nervous system 10 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nervous System Injury 32 85.52 High High
Injury 12 83.36 Quite High
Heart Disease 1 78.76 Quite High
Increased Venous Pressure Under Development 2 65.16 Quite High
Neuropathic Pain 12 62.68 Quite High
Neurological Disease 4 57.20 Quite High
Mucocutaneous Lymph Node Syndrome 2 51.12 Quite High
Ocular Hypertension 94 50.00 Quite Low
Pain 9 50.00 Quite Low
Ganglion Cysts 6 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following ACI, up-regulation of GFAP, OX42 and P2X(4)R expression levels were observed in locus coeruleus of the rats.
Regulation (regulation) of OX42 in locus coeruleus
1) Confidence 0.04 Published 2009 Journal Neurol. Res. Section Body Doc Link 19243685 Disease Relevance 0.16 Pain Relevance 0
Pilot studies indicated there was co-reactivity between ED9 and the majority of OX42 positive events in spinal cord single cell suspensions (Fig. 2B).
Regulation (majority) of OX42 in spinal cord associated with spinal cord
2) Confidence 0.02 Published 2007 Journal J Neurosci Methods Section Body Doc Link PMC2726922 Disease Relevance 0.07 Pain Relevance 0.05
The flow cytometric technique reliably quantified microgliosis in spinal cord cell suspensions, using OX42 and ED9 immunoreactivity to identify microglia.
Regulation (immunoreactivity) of OX42 in spinal cord associated with spinal cord
3) Confidence 0.02 Published 2007 Journal J Neurosci Methods Section Abstract Doc Link PMC2726922 Disease Relevance 0.34 Pain Relevance 0.30
Four micrometer cross-retinal sections with intact optic nerves were used to detect OX42 immunoreactivity.
Regulation (immunoreactivity) of OX42 in optic nerves
4) Confidence 0.00 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2723674 Disease Relevance 0.10 Pain Relevance 0

General Comments

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