INT158260

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Context Info
Confidence 0.23
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 1.51
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tnfrsf4)
Anatomy Link Frequency
spinal 4
retina 1
locus coeruleus 1
Tnfrsf4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 6 65.16 Quite High
adenocard 4 60.28 Quite High
agonist 1 59.12 Quite High
Pain 16 50.00 Quite Low
Neuropathic pain 8 50.00 Quite Low
Perioperative pain 8 50.00 Quite Low
Locus ceruleus 8 50.00 Quite Low
chemokine 7 10.80 Low Low
cytokine 9 6.56 Low Low
Inflammation 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ocular Hypertension 94 99.28 Very High Very High Very High
Injury 7 94.60 High High
Heart Disease 2 90.00 High High
Status Epilepticus 106 82.96 Quite High
Neuropathic Pain 8 71.44 Quite High
Hypersensitivity 16 68.40 Quite High
Convulsion 10 62.72 Quite High
Post Operative Pain 8 50.00 Quite Low
Ganglion Cysts 6 50.00 Quite Low
Pain 4 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: The results of the present study suggest that spinal OX42 expression has a more important role in the development of neuropathic pain than in postoperative pain, and that an increase in spinal OX42 expression does not contribute to postoperative mechanical hypersensitivity.


Gene_expression (expression) of OX42 in spinal
1) Confidence 0.23 Published 2009 Journal Anesthesiology Section Body Doc Link 19672178 Disease Relevance 0.11 Pain Relevance 0
In contrast, in the neuropathic pain model, minocycline reduced mechanical hypersensitivity in a dose-related manner and inhibited spinal OX42 expression.
Gene_expression (expression) of OX42 in spinal
2) Confidence 0.23 Published 2009 Journal Anesthesiology Section Body Doc Link 19672178 Disease Relevance 0.13 Pain Relevance 0
RESULTS: In the postoperative pain model, minocycline did not suppress mechanical hypersensitivity, but did inhibit an increase in spinal OX42 expression.
Gene_expression (expression) of OX42 in spinal
3) Confidence 0.20 Published 2009 Journal Anesthesiology Section Body Doc Link 19672178 Disease Relevance 0.14 Pain Relevance 0
CONCLUSIONS: The results of the present study suggest that spinal OX42 expression has a more important role in the development of neuropathic pain than in postoperative pain, and that an increase in spinal OX42 expression does not contribute to postoperative mechanical hypersensitivity.


Gene_expression (expression) of OX42 in spinal
4) Confidence 0.20 Published 2009 Journal Anesthesiology Section Body Doc Link 19672178 Disease Relevance 0.05 Pain Relevance 0
Following ACI, up-regulation of GFAP, OX42 and P2X(4)R expression levels were observed in locus coeruleus of the rats.
Gene_expression (expression) of OX42 in locus coeruleus
5) Confidence 0.10 Published 2009 Journal Neurol. Res. Section Body Doc Link 19243685 Disease Relevance 0.16 Pain Relevance 0
Afterward, we analysed c-Fos, OX42, GFAP and P2X(4)R expression levels in the LC of the rats by immunofluorescence staining or Western blot analysis.
Spec (analysed) Gene_expression (expression) of OX42
6) Confidence 0.10 Published 2009 Journal Neurol. Res. Section Body Doc Link 19243685 Disease Relevance 0.18 Pain Relevance 0
In normal retina (a), only processes without cell body showing OX42- immunoreactive can be detected.
Gene_expression (detected) of OX42 in retina
7) Confidence 0.01 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2723674 Disease Relevance 0.38 Pain Relevance 0
Therefore, the doses of BzATP, OxATP and IL-1Ra were 43 ?
Gene_expression (doses) of OxATP
8) Confidence 0.00 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2964655 Disease Relevance 0.35 Pain Relevance 0.15

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