INT158267

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.05
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.94
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Alox5) nuclear envelope (Alox5) oxidoreductase activity (Alox5)
nucleus (Alox5) cytoplasm (Alox5)
Anatomy Link Frequency
RBL-1 1
Olr1745 (Rattus norvegicus)
Alox5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 8 97.52 Very High Very High Very High
Analgesic 2 91.96 High High
COX2 4 25.00 Low Low
cOX1 4 25.00 Low Low
Disease Link Frequency Relevance Heat
Leukemia 2 99.08 Very High Very High Very High
INFLAMMATION 8 97.52 Very High Very High Very High
Ulcers 2 96.00 Very High Very High Very High
Pressure And Volume Under Development 2 90.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ZLJ-6 suppressed the activity of 5-lipoxygenase in the rat basophilic leukemia (RBL-1) cell lysate (IC(50)=0.32 microM) and in intact cells (IC(50)=1.06 microM) and reduced the generation of leukotriene B(4) (LTB(4)) in A23187-stimulated human (IC(50)=1.61 microM) or rat whole blood (IC(50)=0.99 microM), and rat peritoneal leukocytes (IC(50)=2.59 microM).
ZLJ-6 Negative_regulation (suppressed) of 5-lipoxygenase in RBL-1 associated with leukemia
1) Confidence 0.05 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19243697 Disease Relevance 0.42 Pain Relevance 0.16
These results indicated that ZLJ-6 potently inhibited 5-lipoxygenase and cyclooxygenase, and blocked the production of LTB(4), TXB(2) and PGE(2).
ZLJ-6 Negative_regulation (inhibited) of 5-lipoxygenase
2) Confidence 0.02 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19243697 Disease Relevance 0.52 Pain Relevance 0.27

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox