INT15827

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Context Info
Confidence 0.54
First Reported 1985
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 4.67
Pain Relevance 3.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Fn1) extracellular region (Fn1) cell adhesion (Fn1)
proteinaceous extracellular matrix (Fn1) extracellular matrix organization (Fn1)
Anatomy Link Frequency
plasma 1
granulocyte 1
liver 1
nerve 1
spinal cord 1
Fn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
neuralgia 6 100.00 Very High Very High Very High
aspirin 4 99.92 Very High Very High Very High
Arthritis 93 99.60 Very High Very High Very High
Spinal cord 10 98.40 Very High Very High Very High
Neuropathic pain 9 97.76 Very High Very High Very High
Peripheral nerve injury 5 96.64 Very High Very High Very High
cINOD 8 95.84 Very High Very High Very High
Inflammation 45 94.64 High High
allodynia 5 91.76 High High
Brush evoked pain 4 89.96 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 43 100.00 Very High Very High Very High
Arthritis 127 99.60 Very High Very High Very High
Nervous System Injury 18 99.22 Very High Very High Very High
Disease 4 98.60 Very High Very High Very High
Injury 1 98.08 Very High Very High Very High
Neuropathic Pain 18 97.76 Very High Very High Very High
Pressure And Volume Under Development 23 95.92 Very High Very High Very High
Disease Progression 2 89.52 High High
Osteoarthritis 3 27.56 Quite Low
Adverse Drug Reaction 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fn levels also remained unaltered in normal animals treated with drugs alone.
Regulation (unaltered) of Fn
1) Confidence 0.54 Published 1985 Journal J. Rheumatol. Section Abstract Doc Link 4057197 Disease Relevance 0.91 Pain Relevance 0.49
Here, we describe the influence of fibronectin on P2X4 receptor expression in microglia and the upregulation of fibronectin after peripheral nerve injury.
Regulation (influence) of fibronectin in microglia associated with nervous system injury and peripheral nerve injury
2) Confidence 0.44 Published 2006 Journal Glia Section Abstract Doc Link 16534777 Disease Relevance 0.77 Pain Relevance 0.40
The effect of antiinflammatory drugs on plasma fibronectin.
Regulation (effect) of fibronectin in plasma associated with aspirin and inflammation
3) Confidence 0.24 Published 1985 Journal J. Rheumatol. Section Title Doc Link 4057197 Disease Relevance 0.95 Pain Relevance 0.47
[Effects of ulinastatin on granulocyte elastase and fibronectin in patients undergoing cardiopulmonary bypass].
Regulation ([Effects) of fibronectin in granulocyte
4) Confidence 0.21 Published 1991 Journal Masui Section Title Doc Link 1766113 Disease Relevance 0 Pain Relevance 0.38
Plasma samples collected from rat liver donors that had received DES showed similar effects on protein concentrations: significant decreases in concentration of plasminogen and antithrombin III were apparent with no significant changes in concentrations of fibrinogen, fibronectin, or albumin.
Neg (no) Regulation (changes) of fibronectin in liver
5) Confidence 0.13 Published 1985 Journal Blood Section Abstract Doc Link 4016277 Disease Relevance 0 Pain Relevance 0.06
Fibronectin/integrin system is involved in P2X(4) receptor upregulation in the spinal cord and neuropathic pain after nerve injury.
Regulation (involved) of Fibronectin in spinal cord associated with neuralgia, nervous system injury, neuropathic pain and spinal cord
6) Confidence 0.10 Published 2008 Journal Glia Section Title Doc Link 18240312 Disease Relevance 0.63 Pain Relevance 0.73
Taken together with the results of our previous study showing an increase in the spinal fibronectin level after nerve injury, the present results suggest that the fibronectin/integrin system participates in the upregulation of P2X(4)R expression after nerve injury and subsequent neuropathic pain.
Regulation (participates) of fibronectin in nerve associated with nervous system injury and neuropathic pain
7) Confidence 0.10 Published 2008 Journal Glia Section Abstract Doc Link 18240312 Disease Relevance 0.91 Pain Relevance 0.72
This applied to the severe loss of proteoglycans in the superficial layer — the layer most strongly affected in the present study (37%) and also that most strongly affected in the fibronectin-mediated arthritis model [19].
Regulation (affected) of fibronectin associated with arthritis
8) Confidence 0.08 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174961 Disease Relevance 0.50 Pain Relevance 0.22

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