INT158295

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Context Info
Confidence 0.53
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 4.02
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CD8A) plasma membrane (CD8A)
Anatomy Link Frequency
T cell 5
monocyte 1
brain 1
lungs 1
CD8A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 78 100.00 Very High Very High Very High
Pain 6 92.36 High High
Inflammation 87 86.28 High High
agonist 34 62.12 Quite High
rheumatoid arthritis 122 50.00 Quite Low
depression 8 36.64 Quite Low
chemokine 8 31.64 Quite Low
headache 8 28.60 Quite Low
fibrosis 10 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 100 99.60 Very High Very High Very High
Herpes Zoster 102 99.54 Very High Very High Very High
Bronchiectasis 70 98.60 Very High Very High Very High
Hepatitis C Virus Infection 15 97.08 Very High Very High Very High
Myalgia 5 93.60 High High
Pain 5 92.36 High High
Chronic Fatigue Syndrome 65 91.76 High High
Pulmonary Disease 64 87.04 High High
Asthma 42 86.68 High High
INFLAMMATION 103 86.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CD8(+) T cell responses were only detected in two of the eight participants receiving the highest dose.
Transcription (detected) of CD8 in T cell
1) Confidence 0.53 Published 2009 Journal Human vaccines Section Abstract Doc Link 19246990 Disease Relevance 0.80 Pain Relevance 0.14
In addition to TLR9, another innate receptor that has recently been described in CD8 is TLR2, which triggers cellular activation similar to that of CD28 [39].
Transcription (described) of CD8
2) Confidence 0.47 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970528 Disease Relevance 0.34 Pain Relevance 0
A positive interaction between aromatherapy and massage was significantly detected for CD8+ cell counts (P = 0.023), i.e. the increase in CD8+ cell counts after aromatherapy massage was significantly larger than the change in the cell counts after control massage.
Transcription (detected) of CD8
3) Confidence 0.29 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1142199 Disease Relevance 0 Pain Relevance 0
In an infection model, a secondary expansion of CD8+ T cells into the brain was observed and was due to the presence of DC in situ [16].
Transcription (expansion) of CD8 in brain associated with infection
4) Confidence 0.29 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2952949 Disease Relevance 0.65 Pain Relevance 0.04
Real-time polymerase chain reaction quantification of T-cell receptor excision circles
Transcription (circles) of T-cell receptor in T-cell
5) Confidence 0.20 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 0.11 Pain Relevance 0.03
3) patients showed a markedly raised CD4:CD8 ratio suggesting that increased peripheral CD4:CD8 T cell ratio is a feature of acute illness.
Transcription (raised) of CD8 in T cell
6) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2872666 Disease Relevance 0.21 Pain Relevance 0.03
In addition CD8+ T cell activity and CD14+ monocyte activity were significantly antagonistic.
Transcription (activity) of CD8 in monocyte
7) Confidence 0.19 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2569951 Disease Relevance 0.34 Pain Relevance 0
Previous studies with VZV viral lysates did not detect CD8 T cell responses ex vivo without prior stimulation [36].
Neg (not) Transcription (detect) of CD8 in T cell associated with herpes zoster
8) Confidence 0.18 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2770849 Disease Relevance 0.46 Pain Relevance 0.07
CD8 T cell responses to Env, Nef and Pol were detected after DNA prime - rAd5 boost, with fewer responders seen after the DNA priming.
Transcription (detected) of CD8 in T cell
9) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943475 Disease Relevance 0.08 Pain Relevance 0.09
Future studies are needed, however, to characterize the expression and function of the non-neuronal cholinergic system in lymphocytes that have infiltrated the lungs and in T lymphocytes that adopted a specific CD8+ or CD4+ phenotype
Transcription (adopted) of CD8 in lungs
10) Confidence 0.10 Published 2006 Journal Respir Res Section Body Doc Link PMC1479816 Disease Relevance 0.56 Pain Relevance 0.14
CD4/CD8 ratio and cytokine levels of the BAL fluid in patients with bronchiectasis caused by sulfur mustard gas inhalation

Objective

Transcription (levels) of CD8 associated with bronchiectasis and cytokine
11) Confidence 0.07 Published 2007 Journal J Inflamm (Lond) Section Title Doc Link PMC1781448 Disease Relevance 0.47 Pain Relevance 0.17

General Comments

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