INT158296

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 4.82
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ctgf) cytosol (Ctgf) extracellular space (Ctgf)
extracellular region (Ctgf) cell adhesion (Ctgf) Golgi apparatus (Ctgf)
Anatomy Link Frequency
myocytes 2
connective tissue 2
heart 2
Ctgf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 47 98.10 Very High Very High Very High
Inflammation 13 94.00 High High
antagonist 2 69.52 Quite High
medulla 2 55.28 Quite High
Pain 2 50.00 Quite Low
anesthesia 12 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
Perioperative pain 3 5.00 Very Low Very Low Very Low
Catecholamine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 235 99.72 Very High Very High Very High
Diabetes Mellitus 166 99.48 Very High Very High Very High
Hypertension 36 98.16 Very High Very High Very High
Cardiovascular Disorder Under Development 10 98.10 Very High Very High Very High
Fibrosis 42 97.20 Very High Very High Very High
Coronary Heart Disease 33 94.00 High High
INFLAMMATION 13 94.00 High High
Stress 36 93.68 High High
Hyperplasia 1 93.32 High High
Aging 2 88.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The strong CTGF expression in the painful disc may be related to disc fibrosis and degeneration.


Positive_regulation (strong) of Gene_expression (expression) of CTGF
1) Confidence 0.47 Published 2009 Journal Spine Section Body Doc Link 19247157 Disease Relevance 0 Pain Relevance 0
Immunohistochemical staining demonstrated strong CTGF expression in the painful discs, weak expression in the asymptomatic degenerative disc, and no expression in the control discs.
Positive_regulation (strong) of Gene_expression (expression) of CTGF
2) Confidence 0.47 Published 2009 Journal Spine Section Body Doc Link 19247157 Disease Relevance 0 Pain Relevance 0
The mRNA expressions of p38-regulated, profibrotic connective tissue growth factor (CTGF) and proinflammatory interleukin -6 (IL-6) tended to be increased in post-MI GK rats (Figure 7C-D).


Positive_regulation (increased) of Gene_expression (expressions) of CTGF in connective tissue associated with myocardial infarction
3) Confidence 0.45 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.37 Pain Relevance 0
In the present study we showed a tendency for IL-6 and CTGF mRNA expressions to be increased after MI in diabetic GK rats.
Positive_regulation (increased) of Gene_expression (expressions) of CTGF mRNA associated with diabetes mellitus and myocardial infarction
4) Confidence 0.36 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.39 Pain Relevance 0.15
However, we already found increased CTGF expression at 2 days in SHR, a stage when presumably no hypertension, let alone fibrosis, is present.
Positive_regulation (increased) of Gene_expression (expression) of CTGF associated with fibrosis and hypertension
5) Confidence 0.35 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2691531 Disease Relevance 0.42 Pain Relevance 0.08
Previous studies have indicated an increase in cardiac fibrosis in response to p38 MAPK overexpression and shown that adenoviral p38-injection into the heart increased CTGF mRNA expression [27].
Positive_regulation (increased) of Gene_expression (expression) of CTGF mRNA in heart associated with fibrosis and cardiovascular disorder under development
6) Confidence 0.26 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.24 Pain Relevance 0.17
And spironolactone blocked connective tissue growth factor (CTGF) expression which was inducted via p38MAPK by aldosterone in ventricular myocytes (27).
Positive_regulation (inducted) of Gene_expression (expression) of tissue growth factor in myocytes
7) Confidence 0.19 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.39 Pain Relevance 0.08

General Comments

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