INT158311

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Context Info
Confidence 0.51
First Reported 2007
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 1.77
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (F2rl3) plasma membrane (F2rl3) signal transducer activity (F2rl3)
Anatomy Link Frequency
neurons 3
joint 1
blood 1
knee joint 1
bladder 1
F2rl3 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 30 100.00 Very High Very High Very High
substance P 21 99.30 Very High Very High Very High
Inflammation 128 99.00 Very High Very High Very High
Inflammatory stimuli 6 98.78 Very High Very High Very High
Inflammatory response 14 97.74 Very High Very High Very High
Antinociceptive 13 96.76 Very High Very High Very High
Nerve growth factor 42 92.64 High High
Neuronal excitability 1 84.44 Quite High
agonist 44 79.96 Quite High
bradykinin 12 78.12 Quite High
Disease Link Frequency Relevance Heat
Arthralgia 3 99.60 Very High Very High Very High
INFLAMMATION 150 99.00 Very High Very High Very High
Overactive Bladder 22 86.04 High High
Pain 26 75.48 Quite High
Arthritis 3 75.12 Quite High
Injury 15 58.88 Quite High
Cystitis 16 51.28 Quite High
Bladder Cancer 4 50.76 Quite High
Nociception 63 50.00 Quite Low
Cancer 2 43.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of protease-activated receptor-4 inhibits the intrinsic excitability of colonic dorsal root ganglia neurons.
Positive_regulation (Activation) of protease-activated receptor-4 in neurons associated with pain
1) Confidence 0.51 Published 2009 Journal Neurogastroenterol. Motil. Section Title Doc Link 19566587 Disease Relevance 0 Pain Relevance 0.29
CONCLUSION: This study demonstrates that local activation of PAR-4 leads to proinflammatory changes in the knee joint that are dependent on the kallikrein-kinin system.
Positive_regulation (activation) of PAR-4 in knee joint
2) Confidence 0.46 Published 2009 Journal Arthritis Rheum. Section Body Doc Link 19248120 Disease Relevance 0.10 Pain Relevance 0
RESULTS: PAR-4 activation caused a long-lasting increase in joint blood flow and edema formation, which was not seen following injection of the control peptide.
Positive_regulation (activation) of PAR-4 in blood
3) Confidence 0.46 Published 2009 Journal Arthritis Rheum. Section Body Doc Link 19248120 Disease Relevance 0.15 Pain Relevance 0
Triggering of proteinase-activated receptor 4 leads to joint pain and inflammation in mice.
Positive_regulation (Triggering) of proteinase-activated receptor 4 in joint associated with pain, arthralgia and inflammation
4) Confidence 0.40 Published 2009 Journal Arthritis Rheum. Section Title Doc Link 19248120 Disease Relevance 0.20 Pain Relevance 0.29
Additional evidence for the participation of PARs in the bladder inflammatory response was the finding that known pro-inflammatory stimuli, such as LPS, substance P, and antigen challenge, induce an increase in PAR4 RNA within hours of stimulation [23].
Positive_regulation (increase) of PAR4 in bladder associated with inflammatory response, substance p and inflammatory stimuli
5) Confidence 0.40 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.92 Pain Relevance 0.45
Other proteases known to activate PAR1 and PAR4 were also effective in causing translocation of PKC?
Positive_regulation (activate) of PAR4
6) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.06 Pain Relevance 0.22
To test this more conclusively it would be desirable to activate PAR3 alone, but specific activation of PAR3 in neurons coexpressing PAR1 and PAR4 is not possible because PAR3 peptides also activate PAR1 and PAR4 [45,46].
Neg (not) Spec (possible) Positive_regulation (activate) of PAR4 in neurons
7) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0 Pain Relevance 0
Out of 345 TFs present in this array, only TFEB was shared by PAR1-, PAR2-, and PAR4 activation.
Positive_regulation (activation) of PAR4
8) Confidence 0.27 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.35 Pain Relevance 0.17
To test this more conclusively it would be desirable to activate PAR3 alone, but specific activation of PAR3 in neurons coexpressing PAR1 and PAR4 is not possible because PAR3 peptides also activate PAR1 and PAR4 [45,46].
Positive_regulation (activation) of PAR4 in neurons
9) Confidence 0.20 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0 Pain Relevance 0

General Comments

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