INT158312

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Context Info
Confidence 0.52
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.80
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (F2rl3) plasma membrane (F2rl3) signal transducer activity (F2rl3)
Anatomy Link Frequency
joint 1
neurons 1
F2rl3 (Mus musculus)
Pain Link Frequency Relevance Heat
hypoalgesia 1 97.76 Very High Very High Very High
antagonist 1 87.52 High High
Antinociceptive 5 82.48 Quite High
qutenza 14 59.84 Quite High
Inflammation 14 50.00 Quite Low
Pain 8 50.00 Quite Low
agonist 14 43.92 Quite Low
nociceptor 16 34.48 Quite Low
bradykinin 4 17.96 Low Low
Inflammatory mediators 3 13.36 Low Low
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

12 98.68 Very High Very High Very High
Hypoalagesia 1 97.76 Very High Very High Very High
Inflammatory Bowel Disease 11 96.48 Very High Very High Very High
Nociception 22 84.80 Quite High
INFLAMMATION 14 50.00 Quite Low
Arthralgia 1 50.00 Quite Low
Diarrhoea 1 48.32 Quite Low
Pain 7 40.64 Quite Low
Arthritis 1 40.28 Quite Low
Hyperalgesia 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, blockade of PAR-4 or Cat-G inhibition resulted in colonic hypersensitivity similar to that observed after IBS-D supernatant infusion.
Negative_regulation (blockade) of PAR-4
1) Confidence 0.52 Published 2009 Journal Pain Section Abstract Doc Link 19450926 Disease Relevance 1.03 Pain Relevance 0.18
Thus, blockade of articular PAR-4 may be a useful means of controlling joint inflammation and pain.


Negative_regulation (blockade) of PAR-4 in joint
2) Confidence 0.37 Published 2009 Journal Arthritis Rheum. Section Body Doc Link 19248120 Disease Relevance 0 Pain Relevance 0
Following desensitization of PAR1 and PAR4, calcium signals in response to thrombin are seen in only a very small number of neurons, far smaller than the proportion in which histological studies had shown expression of PAR3.
Negative_regulation (desensitization) of PAR4 in neurons
3) Confidence 0.17 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0 Pain Relevance 0.06

General Comments

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