INT158327

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.08
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Mcl1) mitochondrion (Mcl1) nucleus (Mcl1)
cytoplasm (Mcl1)
Anatomy Link Frequency
superior 1
cleavage 1
Mcl1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 2 91.64 High High
Inflammation 17 91.12 High High
cINOD 12 82.36 Quite High
chemokine 21 72.00 Quite High
Taxol 2 58.92 Quite High
Kinase C 1 36.88 Quite Low
COX-2 inhibitor 1 14.28 Low Low
cytokine 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 111 100.00 Very High Very High Very High
Repression 5 99.84 Very High Very High Very High
Colon Cancer 28 99.34 Very High Very High Very High
Breast Cancer 72 97.84 Very High Very High Very High
Death 15 94.00 High High
Injury 5 93.00 High High
INFLAMMATION 19 91.12 High High
Acute Renal Failure 1 89.44 High High
Toxicity 6 88.44 High High
Metastasis 35 85.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that the superior sequence-dependent anti-breast cancer activity of EpoB followed by flavopiridol may be due to flavopiridol-induced bax conformational change and downregulation of the anti-apoptotic IAP bcl-xL and Mcl-1 proteins, but this treatment may not overcome the resistance to apoptosis of breast cancer cells conferred by over-expression of bcl-2.
Negative_regulation (downregulation) of Mcl-1 in superior associated with breast cancer and apoptosis
1) Confidence 0.42 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.92 Pain Relevance 0.03
The proapoptotic effect of rolipram was associated with decreased levels of the prosurvival protein Mcl-1 and increased caspase-3 cleavage.
Negative_regulation (decreased) of Mcl-1 in cleavage
2) Confidence 0.24 Published 2010 Journal J. Leukoc. Biol. Section Abstract Doc Link 20103769 Disease Relevance 0.77 Pain Relevance 0.29
Indomethacin treatment was associated with the disruption of mitochondrial transmembrane potential, release of cytochrome c, down-regulation of Bcl-2 and Mcl-1, upregulation of Bax, and elevation of caspases activity.
Negative_regulation (regulation) of Mcl-1
3) Confidence 0.17 Published 2009 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 19250643 Disease Relevance 0.74 Pain Relevance 0.16
Such results agree with our present in vivo findings, which indicate that indomethacin down-regulated Mcl-1, while Bcl-2 and TNF-receptor associated factor 5 were significantly increased.
Negative_regulation (regulated) of Mcl-1
4) Confidence 0.16 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675840 Disease Relevance 0.83 Pain Relevance 0.03
These studies also identify previously uncharacterized interactions between CXCL12 and Bcl-2 family members in colorectal carcinomas through upregulation of Bim and downregulation of Mcl-1.
Negative_regulation (downregulation) of Mcl-1 associated with colon cancer
5) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.82 Pain Relevance 0.04

General Comments

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