INT158341

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Context Info
Confidence 0.58
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.98
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (ALDH2) small molecule metabolic process (ALDH2) oxidoreductase activity (ALDH2)
carbohydrate metabolic process (ALDH2)
ALDH2 (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 101 96.36 Very High Very High Very High
Bioavailability 4 92.96 High High
headache 2 83.76 Quite High
Glutamate 3 56.80 Quite High
depression 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 8 98.56 Very High Very High Very High
Alcohol Addiction 26 94.44 High High
Headache 2 83.76 Quite High
Dizziness 1 83.20 Quite High
Vomiting 2 82.76 Quite High
Disease 13 66.52 Quite High
Alcoholic Cardiomyopathy 2 43.16 Quite Low
Cv Unclassified Under Development 11 38.28 Quite Low
Muscle Disease 1 7.16 Low Low
Cancer 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, siRNAs may be useful in mimicking the Asian phenotype by inhibiting ALDH2 gene expression.
Negative_regulation (inhibiting) of Gene_expression (expression) of ALDH2 gene
1) Confidence 0.58 Published 2009 Journal Alcohol Section Abstract Doc Link 19251111 Disease Relevance 0.51 Pain Relevance 0.33
Deficiency in ALDH2 expression and/or activity is responsible for facial flushing and other vasomotor symptoms following alcohol ingestion.
Negative_regulation (Deficiency) of Gene_expression (expression) of ALDH2 associated with increased venous pressure under development and alcohol
2) Confidence 0.58 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872347 Disease Relevance 0.47 Pain Relevance 0.15
Under these conditions, the effect of ALDH2/GTN even exceeded that of 10 ?
Negative_regulation (exceeded) of Gene_expression (effect) of ALDH2
3) Confidence 0.40 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2801295 Disease Relevance 0 Pain Relevance 0.05

General Comments

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