INT15837

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Context Info
Confidence 0.41
First Reported 1981
Last Reported 2010
Negated 6
Speculated 2
Reported most in Body
Documents 31
Total Number 33
Disease Relevance 12.06
Pain Relevance 3.17

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signal transduction (CGA) small molecule metabolic process (CGA) extracellular region (CGA)
cellular nitrogen compound metabolic process (CGA) cell-cell signaling (CGA)
Anatomy Link Frequency
sella 2
foot 2
myometrium 1
midbrain 1
urine 1
CGA (Homo sapiens)
Pain Link Frequency Relevance Heat
abdominal pain 24 100.00 Very High Very High Very High
Opioid 10 99.98 Very High Very High Very High
Endogenous opioid 6 99.76 Very High Very High Very High
midbrain 4 99.68 Very High Very High Very High
gABA 5 98.82 Very High Very High Very High
Pain 26 96.08 Very High Very High Very High
cva 10 93.28 High High
headache 19 92.24 High High
methotrexate 5 90.08 High High
imagery 6 89.52 High High
Disease Link Frequency Relevance Heat
Abdominal Pain 24 100.00 Very High Very High Very High
Down Syndrome 4 100.00 Very High Very High Very High
Reprotox - General 1 74 99.64 Very High Very High Very High
Thyroid Disease 2 99.60 Very High Very High Very High
Tubal Pregnancy 1 99.52 Very High Very High Very High
Cancer 30 98.92 Very High Very High Very High
Syndrome 20 98.92 Very High Very High Very High
Reprotox - General 2 72 98.74 Very High Very High Very High
Encephalitis 2 98.50 Very High Very High Very High
Hyperemesis Gravidarum 1 97.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the European Union, a combination of follitropin alpha and lutropin alpha (Pergoveris™) is currently available for single subcutaneous injection.17 The ratio of follitropin alpha to lutropin alpha in that preparation is 2:1, respectively.
lutropin alpha Binding (combination) of
1) Confidence 0.41 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819896 Disease Relevance 0.25 Pain Relevance 0.15
In the European Union, a combination of follitropin alpha and lutropin alpha (Pergoveris™) is currently available for single subcutaneous injection.17 The ratio of follitropin alpha to lutropin alpha in that preparation is 2:1, respectively.
follitropin alpha Binding (combination) of
2) Confidence 0.41 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819896 Disease Relevance 0.25 Pain Relevance 0.15
[Influence of human chorionic gonadotropin (hCG) in combination with a 500 calorie diet on clinical and laboratory parameters in premenopausal women with and without hormonal contraception].
hCG Binding (combination) of
3) Confidence 0.37 Published 1987 Journal Aktuel Endokrinol Stoffwechsel Section Title Doc Link 12281505 Disease Relevance 0.12 Pain Relevance 0
RESULTS: ES was thinner with increased vaginal bleeding and associated with hCG level and pregnancy outcome.
hCG Binding (associated) of
4) Confidence 0.37 Published 2007 Journal J Reprod Med Section Body Doc Link 17939589 Disease Relevance 0.17 Pain Relevance 0
In the following communication we discuss evidence suggesting that an abnormal opioid-gonadotrophin interaction at the midbrain may be essential to the clinical expression of vocal tics in Tourette's Syndrome (TS).
gonadotrophin Binding (interaction) of in midbrain associated with tics, syndrome, midbrain and opioid
5) Confidence 0.36 Published 1991 Journal Med. Hypotheses Section Abstract Doc Link 1766421 Disease Relevance 0.53 Pain Relevance 0.34
Data derived from animal studies and the striking similarity between the symptomatology of TS and encephalitis lethargica (EL) add further support to our hypothesis implicating an abnormal opioid-gonadotrophin interaction in the pathophysiology of TS.
gonadotrophin Binding (interaction) of associated with syndrome, encephalitis and opioid
6) Confidence 0.36 Published 1991 Journal Med. Hypotheses Section Abstract Doc Link 1766421 Disease Relevance 0.65 Pain Relevance 0.34
The patient's human chorionic gonadotropin level was markedly elevated, as often occurs with fetal trisomy 21, and was likely associated with the ovarian hyperstimulation.
chorionic gonadotropin Binding (associated) of associated with down syndrome
7) Confidence 0.36 Published 2009 Journal J Perinatol Section Abstract Doc Link 19398998 Disease Relevance 0.72 Pain Relevance 0.09
Two weeks later, the patient presented with abdominal pain and rising serum beta-human chorionic gonadotrophin (beta-HCG).
chorionic gonadotrophin Binding (presented) of associated with abdominal pain
8) Confidence 0.33 Published 2006 Journal Reprod. Biomed. Online Section Abstract Doc Link 16792857 Disease Relevance 0.57 Pain Relevance 0.13
Two weeks later, the patient presented with abdominal pain and rising serum beta-human chorionic gonadotrophin (beta-HCG).
beta-HCG Binding (presented) of associated with abdominal pain
9) Confidence 0.33 Published 2006 Journal Reprod. Biomed. Online Section Abstract Doc Link 16792857 Disease Relevance 0.57 Pain Relevance 0.13
Chronic ectopic pregnancy is an uncommon form of tubal pregnancy manifested as a pelvic mass with minimal symptoms and a low or absent titer of human chorionic gonadotropin.
gonadotropin Binding (mass) of associated with reprotox - general 2 and tubal pregnancy
10) Confidence 0.32 Published 1997 Journal Ultrasound Obstet Gynecol Section Abstract Doc Link 9201879 Disease Relevance 0.35 Pain Relevance 0.08
The 75 IU rLH dose was found to be effective in 94% of the treatment cycles.36 The cumulative pregnancy rate following three cycles of stimulation with follitropin alpha and lutropin alpha was 39.5%.36 Clinical pregnancy occurred in 16 out of the 31 women received lutropin alpha with follitropin alpha in an extension phase of the randomized trial published by O’Dea et al in 2000 on severely hypogonadotrophic women.116 Two case reports documented pregnancies in 2 women with Kallman syndrome (amenorrhea, anosmia and hypogonadotrophic hypogonadism) and empty sella syndrome who received follitropin alpha and rLH.117,118

WHO group II anovulation

follitropin alpha Binding (stimulation) of in sella associated with reprotox - general 2, syndrome, anovulation, empty sella syndrome, loss of sense of smell and reprotox - general 1
11) Confidence 0.32 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819896 Disease Relevance 0.67 Pain Relevance 0
A randomized crossover trial had demonstrated bioequivalence between follitropin alpha and lutropin alpha administered alone or in this fixed 2:1 combination.110


follitropin alpha Binding (bioequivalence) of
12) Confidence 0.32 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819896 Disease Relevance 0.17 Pain Relevance 0.16
This delivery system has been shown to improve patient compliance and satisfaction.82,147,148 A randomized trial comparing follitropin alpha in a pen device to the conventional syringe has shown that the former is associated with significantly higher rates of self-administration and satisfaction, with significantly less pain and local reactions at the injection site.149 A questionnaire based study on ease-of-use, safety and efficacy of two follitropin injection pens found the follitropin alpha pen to be effective, well tolerated with higher patient and nurse acceptance than the follitropin beta pen.150

Economic evaluation

follitropin alpha Spec (found) Binding (associated) of associated with pain
13) Confidence 0.32 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819896 Disease Relevance 0.47 Pain Relevance 0.10
A randomized crossover trial had demonstrated bioequivalence between follitropin alpha and lutropin alpha administered alone or in this fixed 2:1 combination.110


lutropin alpha Binding (bioequivalence) of
14) Confidence 0.32 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819896 Disease Relevance 0.18 Pain Relevance 0.16
The 75 IU rLH dose was found to be effective in 94% of the treatment cycles.36 The cumulative pregnancy rate following three cycles of stimulation with follitropin alpha and lutropin alpha was 39.5%.36 Clinical pregnancy occurred in 16 out of the 31 women received lutropin alpha with follitropin alpha in an extension phase of the randomized trial published by O’Dea et al in 2000 on severely hypogonadotrophic women.116 Two case reports documented pregnancies in 2 women with Kallman syndrome (amenorrhea, anosmia and hypogonadotrophic hypogonadism) and empty sella syndrome who received follitropin alpha and rLH.117,118

WHO group II anovulation

lutropin alpha Binding (stimulation) of in sella associated with reprotox - general 2, syndrome, anovulation, empty sella syndrome, loss of sense of smell and reprotox - general 1
15) Confidence 0.32 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819896 Disease Relevance 0.68 Pain Relevance 0
In males with hypogonadotrophic hypogonadism presented by azospermia or sever oligoasthenoteratospermia, rFSH may be effective in achieving spermatogenesis when combined with HCG.141–144 Combined analysis of data from four clinical trials shows that HCG and rFSH induced spermatogenesis in 84% of men with hypogonadotrophic hypogonadism.145 A number of baseline factors, including mean testicular volume, body mass index, age of disease onset and response to previous therapy, has been shown to influence the response.145,146


Patient satisfaction

HCG Binding (combined) of in body associated with reprotox - general 2, obesity and disease
16) Confidence 0.28 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819896 Disease Relevance 0.54 Pain Relevance 0
Luteinizing hormone (LH) was measured by a novel and specific assay that does not cross-react with human chorionic gonadotropin (hCG).
hCG Neg (not) Binding (cross) of
17) Confidence 0.21 Published 1989 Journal Fertil. Steril. Section Abstract Doc Link 2494080 Disease Relevance 0 Pain Relevance 0.07
The ELISAs for determination of urine i-hCG levels and hCGRP/i-hCG, using monoclonal antibodies that specifically recognize the structural changes of hCG isoforms and degradation products, offer better diagnostic outcomes than hCG quantification combined with ultrasonography (80% sensitivity) which is currently known as the best diagnostic method for ectopic pregnancy (13).
hCG Binding (recognize) of in urine associated with ectopic pregnancy
18) Confidence 0.19 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2782204 Disease Relevance 0.52 Pain Relevance 0
Luteinizing hormone (LH) was measured by a novel and specific assay that does not cross-react with human chorionic gonadotropin (hCG).
gonadotropin Neg (not) Binding (react) of
19) Confidence 0.18 Published 1989 Journal Fertil. Steril. Section Abstract Doc Link 2494080 Disease Relevance 0 Pain Relevance 0.07
Metastatic choriocarcinoma was accidentally found with positive immunohistochemical staining of cytokeratin and beta subunit of human chorionic gonadotropin (beta-HCG).
chorionic gonadotropin Binding (found) of associated with reprotox - general 1
20) Confidence 0.18 Published 2007 Journal Int. J. Gynecol. Cancer Section Abstract Doc Link 17425677 Disease Relevance 1.24 Pain Relevance 0.40

General Comments

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