INT158377

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 3.08
Pain Relevance 4.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Rela) nucleus (Rela) DNA binding (Rela)
protein complex (Rela) transcription factor binding (Rela) cytoplasm (Rela)
Anatomy Link Frequency
DRG 8
Rela (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 20 98.86 Very High Very High Very High
Inflammation 47 97.12 Very High Very High Very High
analgesia 16 94.20 High High
Spinal cord 8 92.28 High High
antagonist 5 81.96 Quite High
Dorsal horn 4 77.92 Quite High
central sensitization 4 77.16 Quite High
IPN 8 75.00 Quite High
Central nervous system 15 74.32 Quite High
Inflammatory response 5 67.36 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 20 98.86 Very High Very High Very High
INFLAMMATION 49 97.12 Very High Very High Very High
Inflammatory Pain 8 75.00 Quite High
Nociception 4 73.24 Quite High
Disease 34 50.56 Quite High
Demyelinating Disease 6 50.48 Quite High
Death 8 50.00 Quite Low
Infection 11 47.88 Quite Low
Parkinson's Disease 12 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Induction of DRG mGlu2 receptors in response to SAHA was associated with increased acetylation of p65/RelA on lysine 310, a process that enhances the transcriptional activity of p65/RelA at nuclear factor-kappaB-regulated genes.
Positive_regulation (enhances) of Positive_regulation (enhances) of p65 in DRG associated with dorsal root ganglion
1) Confidence 0.49 Published 2009 Journal Mol. Pharmacol. Section Abstract Doc Link 19255242 Disease Relevance 0.65 Pain Relevance 0.94
Induction of DRG mGlu2 receptors in response to SAHA was associated with increased acetylation of p65/RelA on lysine 310, a process that enhances the transcriptional activity of p65/RelA at nuclear factor-kappaB-regulated genes.
Positive_regulation (increased) of Positive_regulation (acetylation) of RelA in DRG associated with dorsal root ganglion
2) Confidence 0.49 Published 2009 Journal Mol. Pharmacol. Section Abstract Doc Link 19255242 Disease Relevance 0.65 Pain Relevance 0.96
Induction of DRG mGlu2 receptors in response to SAHA was associated with increased acetylation of p65/RelA on lysine 310, a process that enhances the transcriptional activity of p65/RelA at nuclear factor-kappaB-regulated genes.
Positive_regulation (increased) of Positive_regulation (acetylation) of p65 in DRG associated with dorsal root ganglion
3) Confidence 0.49 Published 2009 Journal Mol. Pharmacol. Section Abstract Doc Link 19255242 Disease Relevance 0.65 Pain Relevance 0.96
Induction of DRG mGlu2 receptors in response to SAHA was associated with increased acetylation of p65/RelA on lysine 310, a process that enhances the transcriptional activity of p65/RelA at nuclear factor-kappaB-regulated genes.
Positive_regulation (enhances) of Positive_regulation (activity) of RelA in DRG associated with dorsal root ganglion
4) Confidence 0.49 Published 2009 Journal Mol. Pharmacol. Section Abstract Doc Link 19255242 Disease Relevance 0.65 Pain Relevance 0.94
The transcriptional activation of p65 and p50, the accumulation of p65 protein, and the induction of ICAM-1 were all attenuated in the Fc?
Positive_regulation (attenuated) of Positive_regulation (activation) of p65
5) Confidence 0.30 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2975641 Disease Relevance 0.05 Pain Relevance 0.03
Activated GC receptors (GRs) are able to interfere with the transactivation potential of the p65 NF-?
Positive_regulation (transactivation) of Positive_regulation (potential) of p65
6) Confidence 0.10 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.42 Pain Relevance 0.28

General Comments

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