INT158400

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Context Info
Confidence 0.36
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.76
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD80, CD86) cell-cell signaling (CD80, CD86) intracellular (CD80)
Anatomy Link Frequency
CD86 2
T cell 1
CD80 (Homo sapiens)
CD86 (Homo sapiens)
Pain Link Frequency Relevance Heat
abatacept 8 93.12 High High
psoriasis 5 87.36 High High
rheumatoid arthritis 54 83.04 Quite High
Inflammation 62 57.60 Quite High
Arthritis 13 42.56 Quite Low
cytokine 28 31.68 Quite Low
withdrawal 2 25.60 Quite Low
tolerance 7 5.00 Very Low Very Low Very Low
corticosteroid 5 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Psoriasis 5 87.36 High High
Graft Vs Host Disease 3 85.88 High High
Organ Transplantation 2 84.80 Quite High
Rheumatoid Arthritis 54 83.04 Quite High
Adhesions 4 81.76 Quite High
Immune System Diseases 2 63.52 Quite High
INFLAMMATION 59 57.60 Quite High
Disease 24 49.96 Quite Low
Autoimmune Disease 18 45.24 Quite Low
Adverse Drug Reaction 2 42.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BACKGROUND: It has been proposed that ligation of CD80 and CD86 induces reverse signaling into antigen-presenting cells.
CD80 Binding (ligation) of CD86 in CD86
1) Confidence 0.36 Published 2009 Journal J. Clin. Immunol. Section Abstract Doc Link 19259798 Disease Relevance 0 Pain Relevance 0.17
This signal is mediated by the interaction of CD80 (B7.1) and CD86 (B7.2) on antigen-presenting cells with specific T cell receptors (CD28 and its homolog, cytotoxic T lymphocyte-associated antigen 4 [CTLA4]).
CD80 Binding (interaction) of CD86 in T cell
2) Confidence 0.17 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2998809 Disease Relevance 0 Pain Relevance 0
Because CD152 has a high affinity for CD80 and CD86, soluble forms of CTLA4 inhibit the interaction of CD28 with its ligands.
CD80 Binding (affinity) of CD86 in CD86
3) Confidence 0.07 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.76 Pain Relevance 0.31

General Comments

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